Toward a Phenomenological Pragmatics of Enactive Perception

The enactive approach to perception is generating an extensive amount of interest and debate in the cognitive sciences. One particularly contentious issue has been how best to characterize the perceptual experiences reported by subjects who have mastered the skillful use of a perceptual supplementation (PS) device. This paper argues that this issue cannot be resolved with the use of third-person methodologies alone, but that it requires the development of a phenomenological pragmatics. In particular, it is necessary that the experimenters become skillful in the use of PS devices themselves. The "Enactive Torch" is proposed as an experimental platform which is cheap, non-intrusive and easy to replicate, so as to enable researchers to corroborate reported experiences with their own phenomenology more easily

Proteostasis collapse is a driver of cell aging and death.

What molecular processes drive cell aging and death? Here, we model how proteostasis-i.e., the folding, chaperoning, and maintenance of protein function-collapses with age from slowed translation and cumulative oxidative damage. Irreparably damaged proteins accumulate with age, increasingly distracting the chaperones from folding the healthy proteins the cell needs. The tipping point to death occurs when replenishing good proteins no longer keeps up with depletion from misfolding, aggregation, and damage. The model agrees with experiments in the worm Caenorhabditis elegans that show the following: Life span shortens nonlinearly with increased temperature or added oxidant concentration, and life span increases in mutants having more chaperones or proteasomes. It predicts observed increases in cellular oxidative damage with age and provides a mechanism for the Gompertz-like rise in mortality observed in humans and other organisms. Overall, the model shows how the instability of proteins sets the rate at which damage accumulates with age and upends a cell's normal proteostasis balance

Role of Proteome Physical Chemistry in Cell Behavior.

We review how major cell behaviors, such as bacterial growth laws, are derived from the physical chemistry of the cell's proteins. On one hand, cell actions depend on the individual biological functionalities of their many genes and proteins. On the other hand, the common physics among proteins can be as important as the unique biology that distinguishes them. For example, bacterial growth rates depend strongly on temperature. This dependence can be explained by the folding stabilities across a cell's proteome. Such modeling explains how thermophilic and mesophilic organisms differ, and how oxidative damage of highly charged proteins can lead to unfolding and aggregation in aging cells. Cells have characteristic time scales. For example, E. coli can duplicate as fast as 2-3 times per hour. These time scales can be explained by protein dynamics (the rates of synthesis and degradation, folding, and diffusional transport). It rationalizes how bacterial growth is slowed down by added salt. In the same way that the behaviors of inanimate materials can be expressed in terms of the statistical distributions of atoms and molecules, some cell behaviors can be expressed in terms of distributions of protein properties, giving insights into the microscopic basis of growth laws in simple cells

The group structure of non-Abelian NS-NS transformations

We study the transformations of the worldvolume fields of a system of multiple coinciding D-branes under gauge transformations of the supergravity Kalb-Ramond field. We find that the pure gauge part of these NS-NS transformations can be written as a U(N) symmetry of the underlying Yang-Mills group, but that in general the full NS-NS variations get mixed up non-trivially with the U(N). We compute the commutation relations and the Jacobi identities of the bigger group formed by the NS-NS and U(N) transformations.Comment: Latex, 11 pages. v2: Typos corrected; version to appear in JHEP

The Role of Zakat in Poverty Alleviation in Somalia "Analytical Study on Islamic Economics"

The Role of Zakat in Poverty Alleviation in Somalia “Analytical Study on Islamic Economics” Mr. Adam Ahmed Hussein Head department quality control, Mogadishu Universit

An In Depth Analyses of Specific Language Impairment as Compared to Other Developmental Disorders

Specific language impairment (SLI), defined as a disproportionate difficulty in learning language despite having normal hearing, intelligence, and no known neurological or emotional impairment, has been shown to share similar cognitive characteristics with individuals with attention deficit hyperactive disorder (ADHD). However, little research has investigated the dissimilarities in these two different developmental disorders. Children with SLI also show many similar symptoms with individuals diagnosed with dyslexia. The aim of these studies is to get a better understanding of cognitive differences between SLI and ADHD, and the cognitive similarities between SLI and dyslexia. Tests of both verbal and non-verbal measures of working memory, IQ, and academic performance were administered to all groups. It was hypothesized that children with SLI would perform worse on verbal measures due to their language deficits but perform better on non-verbal measures than children with ADHD. It was also predicted that children with SLI will perform similarly, but worse than children with dyslexia. Results from the SLI/ADHD experiment confirm this pattern: children with SLI performed poorer than children with ADHD on all verbal cognitive measures. When looking at the non-verbal measures of abilities, the SLI group outperformed the ADHD group on working memory and IQ scores but not academic performance scores. Results from the SLI/Dyslexia experiment also confirmed what was predicted. Children with dyslexia outperformed their SLI counterparts on all cognitive measures. A possible explanation for these finding is that there are fewer classroom-based programs designed specifically to support children with SLI

Revitalizing downtown Springfield Illinois

Looking to revitalize the downtown Springfield area, this abstract outlines the benefits of an urban park as a catalyst for housing and commercial development. In order to combat the issues presented in the capitol city, Springfield hopes bringing people back to its core will restore the area

League of Conservation Voters v. Trump

A consortium of environmental groups brought suit challenging an executive order opening millions of acres of continental shelf lands to oil and gas leasing. The Court held that the President’s actions exceeded his statutory authority and intruded on Congress’s power under the Property Clause, violating the separation of powers doctrine

The Relationship Between Resilience, Stress & PTSD

Post-traumatic stress disorder (PTSD) is characterized by intrusive thoughts or memories of the traumatic event that hinder daily life activities of individuals with a PTSD diagnosis. Stress exposure has further been shown to exacerbate PTSD symptoms. Given that resilience has been shown to buffer levels of stress, the current study investigated whether resilience may moderate the relationship between stress and PTSD symptoms. Eighty-one participants over the age of 18 were recruited from the University of Missouri-Saint Louis and St. Louis community. Participants completed 3 self-report measures of resilience, exposure to stressful life events (e.g., Have you ever been in a car accident before?), and PTSD symptoms. In support our first hypothesis, we found that stress exposure was associated with greater PTSD symptoms (b = 2.08, t(77) = 5.02, p \u3c .001). However, resilience did not moderate the relationship between stress exposure and PTSD symptoms (B = -0.01, p = .68). Future studies may examine the influence of medications on PTSD, chronic stress, and resilience

Analytic Versus Non-Analytic Decision Makers and Their Effect on Win Percentage after In-season Player Acquisitions

This paper examines whether teams with winning records that employ analytic decision makers see a higher increase in win percentage after in-season player acquisitions versus teams that employ non-analytic decision makers. This was accomplished through analyzing the in-season player acquisition data from the MLB and NBA over the last four completed seasons through descriptive and inferential statistics. There was not a significant difference between the two groups in average win percentage after total acquisitions, trades, or signings. Using inferential tests we found no statistical significance between the type of decision maker, and the difference in win percentage after an acquisition