605 research outputs found

    Discovering Tau and Muon Solar Neutrino Flares above backgrounds

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    Solar neutrino flares astronomy is at the edge of its discover. High energy flare particles (protons, alpha) whose self scattering within the solar corona is source of a rich prompt charged pions are also source of sharp solar neutrino "burst" (at tens-hundred MeV) produced by their pion-muon primary decay in flight. This brief (minute) solar neutrino "burst" at largest peak overcome by four-five order of magnitude the steady atmospheric neutrino noise at the Earth. Later on, solar flare particles hitting the terrestrial atmosphere may marginally increase the atmospheric neutrino flux without relevant consequences. Largest prompt "burst" solar neutrino flare may be detected in present or better in future largest neutrino underground neutrino detectors. Our estimate for the recent and exceptional October - November 2003 solar flares gives a number of events above or just near unity for Super-Kamiokande. The neutrino spectra may reflect in a subtle way the neutrino flavour mixing in flight. A surprising tau appearance may even occur for a hard ({E}_{nu}_{mu}--> {E}_{nu}_{tau} > 4 GeV) flare spectra. A comparison of the solar neutrino flare (at their birth place on Sun and after oscillation on the arrival on the Earth) with other neutrino foreground is here described and it offer an independent road map to disentangle the neutrino flavour puzzles and its secret flavour mixing angles .Comment: 10 pages, 7 figures, Noon 2004 Conference, Februry 200

    Muon and Tau Neutrinos Spectra from Solar Flares

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    Solar neutrino flares and mixing are considered. Most power-full solar flare as the ones occurred on 23th February 1956, September 29th 1989, 28th October and on 2nd-4th November 2003 are sources of cosmic rays, X, gamma and neutrino bursts. These flares took place both on front or in the edge and in the hidden solar disk. The observed and estimated total flare energy should be a source of a prompt secondary neutrino burst originated, by proton-proton-pion production on the sun itself; a more delayed and spread neutrino flux signal arise by the solar charged flare particles reaching the terrestrial atmosphere. Our first estimates of neutrino signals in largest underground detectors hint for few events in correlation with, gamma,radio onser. Our approximated spectra for muons and taus from these rare solar eruption are shown over the most common background. The muon and tau signature is very peculiar and characteristic over electron and anti-electron neutrino fluxes. The rise of muon neutrinos will be detectable above the minimal muon threshold of 113 MeV. The rarest tau appearence will be possible only for hardest solar neutrino energies above 3.471 GeVComment: 14 pages, 4 figures, Vulcano Conference 200

    Unveiling Clusters of RNA Transcript Pairs Associated with Markers of Alzheimer's Disease Progression

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    Background: One primary goal of transcriptomic studies is identifying gene expression patterns correlating with disease progression. This is usually achieved by considering transcripts that independently pass an arbitrary threshold (e.g. p<0.05). In diseases involving severe perturbations of multiple molecular systems, such as Alzheimer's disease (AD), this univariate approach often results in a large list of seemingly unrelated transcripts. We utilised a powerful multivariate clustering approach to identify clusters of RNA biomarkers strongly associated with markers of AD progression. We discuss the value of considering pairs of transcripts which, in contrast to individual transcripts, helps avoid natural human transcriptome variation that can overshadow disease-related changes. Methodology/Principal Findings: We re-analysed a dataset of hippocampal transcript levels in nine controls and 22 patients with varying degrees of AD. A large-scale clustering approach determined groups of transcript probe sets that correlate strongly with measures of AD progression, including both clinical and neuropathological measures and quantifiers of the characteristic transcriptome shift from control to severe AD. This enabled identification of restricted groups of highly correlated probe sets from an initial list of 1,372 previously published by our group. We repeated this analysis on an expanded dataset that included all pair-wise combinations of the 1,372 probe sets. As clustering of this massive dataset is unfeasible using standard computational tools, we adapted and re-implemented a clustering algorithm that uses external memory algorithmic approach. This identified various pairs that strongly correlated with markers of AD progression and highlighted important biological pathways potentially involved in AD pathogenesis. Conclusions/Significance: Our analyses demonstrate that, although there exists a relatively large molecular signature of AD progression, only a small number of transcripts recurrently cluster with different markers of AD progression. Furthermore, considering the relationship between two transcripts can highlight important biological relationships that are missed when considering either transcript in isolation. © 2012 Arefin et al

    Screening of at-risk blood donors for Chagas disease in non-endemic countries: Lessons from a 2-year experience in Tuscany, Italy

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    Background: Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi and is transmitted by blood-sucking triatomine insects in endemic areas of Latin America. Transmission can also occur via blood transfusion and is a major cause of CD in non-endemic areas. Objectives: The aim of the study was to assess the prevalence of anti-T. cruzi antibodies in blood donors at risk of infection in Tuscany, Italy, following the introduction of blood safety Italian legislation. Material and methods: Donors (N = 1985) were tested in 2016 to 2018 for anti-T. cruzi IgG using an immunochromatographic test (ICT). Chemiluminescent immunoassay (CLIA) was performed on ICT-positive donors to exclude CD, whereas enzyme-linked immunosorbent assay and Western blot were performed in case of discordant results. All assays were performed on CD patients (N = 10) for validation. Results: Ten blood donors had a positive ICT result, with a resulting T. cruzi seroprevalence of 0.5% but demonstrates negative results to CLIA, as well as to the other serological assays. The comparison of serological assays suggested a lower relative sensitivity of ICT. Conclusion: The results of this study confirm the significance of serological testing in the screening strategy for TT CD. However, they provide evidence for discontinuing the use of ICT as a screening test and suggest that a sensitive, specific and multi-sample format assay should be used at the national level for uniformity of results
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