4,992 research outputs found
Photonic crystal resonator integrated in a microfluidic system
We report on a novel optofluidic system consisting of a silica-based 1D
photonic crystal, integrated planar waveguides and electrically insulated
fluidic channels. An array of pillars in a microfluidic channel designed for
electrochromatography is used as a resonator for on-column label-free
refractive index detection. The resonator was fabricated in a silicon
oxynitride platform, to support electroosmotic flow, and operated at 1.55
microns. Different aqueous solutions of ethanol with refractive indices ranging
from n = 1.3330 to 1.3616 were pumped into the column/resonator and the
transmission spectra were recorded. Linear shifts of the resonant wavelengths
yielded a maximum sensitivity of 480 nm/RIU and a minimum difference of 0.007
RIU was measured
Nanoplasmonics beyond Ohm's law
In tiny metallic nanostructures, quantum confinement and nonlocal response
change the collective plasmonic behavior with important consequences for e.g.
field-enhancement and extinction cross sections. We report on our most recent
developments of a real-space formulation of an equation-of-motion that goes
beyond the common local-response approximation and use of Ohm's law as the
central constitutive equation. The electron gas is treated within a
semi-classical hydrodynamic model with the emergence of a new intrinsic length
scale. We briefly review the new governing wave equations and give examples of
applying the nonlocal framework to calculation of extinction cross sections and
field enhancement in isolated particles, dimers, and corrugated surfaces.Comment: Invited paper for TaCoNa-Photonics 2012 (www.tacona-photonics.org),
to appear in AIP Conf. Pro
Chromatin as a target antigen in human and murine lupus nephritis
The present review focuses on pathogenic molecular and transcriptional events in patients with lupus nephritis. These factors are renal DNaseI, exposed chromatin fragments and the corresponding chromatin-reactive autoantibodies. Lupus nephritis is the most serious complication in human systemic lupus erythematosus, and is characterised by deposition of chromatin fragment-IgG complexes in the mesangial matrix and glomerular basement membranes. The latter deposition defines end-stage disease. This event is stringently linked to a renal-restricted shutdown of expression of the DNaseI gene, as determined by loss of DNaseI mRNA level and DNaseI enzyme activity. The major aim of the present review is to generate new therapeutic strategies based on new insight into the disease pathogenesis
Low-loss criterion and effective area considerations for photonic crystal fibers
We study the class of endlessly single-mode all-silica photonic crystal
fibers with a triangular air-hole cladding. We consider the sensibility to
longitudinal nonuniformities and the consequences and limitations for realizing
low-loss large-mode area photonic crystal fibers. We also discuss the
dominating scattering mechanism and experimentally we confirm that both macro
and micro-bending can be the limiting factor.Comment: Accepted for Journal of Optics A - Pure and Applied Optic
Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety, and Effects on Quality of Life
Background and aims. Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients in a short-term study. This study describes safety, compliance, and changes in quality of life in 11 SBS patients at baseline, week 13, 26, and 52 during two years of subcutaneous GLP-2 treatment, 400 microgram TID, intermitted by an 8-week washout period.
Methods. Safety and compliance was evaluated during the admissions. The Sickness Impact Profile (SIP), Short Form 36 (SF 36), and Inflammatory Bowel Disease Questionnaire (IBDQ) evaluated quality of life.
Results. The predominant adverse event was transient abdominal discomfort in 5 of 11 patients, but in 2, both suffering from Crohns disease, it progressed to abdominal pain and led to discontinuation of GLP-2 treatment. One had a fibrostenotic lesion electively resected at the jejuno-ascendo-anastomosis. The investigator excluded a patient due to unreliable feedback. Stoma nipple enlargement was seen in all 9 jejunostomy patients. Reported GLP-2 compliance was excellent (>93%). GLP-2 improved the overall quality of life VAS-score (4.1 ± 2.8 cm versus 6.0 ± 2.4 cm, P < .01), the overall SIP score (10.3 ± 8.9% versus 6.2 ± 9.5%, P < .001), the mental component of the SF-36 (45 ± 13% versus 53 ± 11%, P < .05), and the overall IBDQ score (5.1 ± 0.9 versus 5.4 ± 0.9, P < .007) in the 8 patients completing the study.
Conclusions. Long-term treatment with GLP-2 is feasible in SBS patients, although caution must be exercised in patients with a history of abdominal pain. Although conclusions cannot be made in a noncontrolled trial, the high reported compliance might reflect a high treatment satisfaction, where the clinical benefits of GLP-2 may outweigh the discomforts of injections
Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2: Effects on Intestinal Morphology and Absorption, Renal Function, Bone and Body Composition, and Muscle Function
Background and aims. In a short-term study, Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients. This study describes longitudinal changes in relation to GLP-2 treatment for two years.
Methods. GLP-2, 400 micrograms, s.c.,TID, were offered, to eleven SBS patients keeping parenteral support constant. 72-hour nutritional balance studies were performed at baseline, weeks 13, 26, 52 during two years intermitted by an 8-week washout period. In addition, mucosal morphometrics, renal function (by creatinine clearance), body composition and bone mineral density (by DEXA), biochemical markers of bone turnover (by s-CTX and osteocalcin, PTH and vitamin D), and muscle function (NMR, lungfunction, exercise test) were measured. Results. GLP-2 compliance was >93%. Three of eleven patients did not complete the study. In the remaining 8 patients, GLP-2 significantly reduced the fecal wet weight from approximately 3.0 to approximately 2.0 kg/day. This was accompanied by a decline in the oral wet weight intake, maintaining intestinal wet weight absorption and urinary weight constant. Renal function improved. No significant changes were demonstrated in energy intake or absorption, and GLP-2 did not significantly affect mucosal morphology, body composition, bone mineral density or muscle function. Conclusions. GLP-2 treatment reduces fecal weight by approximately 1000 g/d and enables SBS patients to maintain their intestinal fluid and electrolyte absorption at lower oral intakes. This was accompanied by a 28% improvement in creatinine clearance
Bayesian Error Estimation in Density Functional Theory
We present a practical scheme for performing error estimates for Density
Functional Theory calculations. The approach which is based on ideas from
Bayesian statistics involves creating an ensemble of exchange-correlation
functionals by comparing with an experimental database of binding energies for
molecules and solids. Fluctuations within the ensemble can then be used to
estimate errors relative to experiment on calculated quantities like binding
energies, bond lengths, and vibrational frequencies. It is demonstrated that
the error bars on energy differences may vary by orders of magnitude for
different systems in good agreement with existing experience.Comment: 5 pages, 3 figure
Non-Destructive Identification of Cold and Extremely Localized Single Molecular Ions
A simple and non-destructive method for identification of a single molecular
ion sympathetically cooled by a single laser cooled atomic ion in a linear Paul
trap is demonstrated. The technique is based on a precise determination of the
molecular ion mass through a measurement of the eigenfrequency of a common
motional mode of the two ions. The demonstrated mass resolution is sufficiently
high that a particular molecular ion species can be distinguished from other
equally charged atomic or molecular ions having the same total number of
nucleons
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