Association between diverticulosis and colonic neoplastic lesions in individuals with a positive faecal immunochemical test

Background The association between diverticulosis and colonic neoplastic lesions has been suggested, but data in literature are conflicting. This study aimed to investigate such a relationship in patients participating in a colorectal cancer screening program who underwent high-quality colonoscopy.Methods Data from consecutive individuals 50-75 years of age with a positive faecal immunological test were considered. Diverticulosis was categorised as present or absent. The prevalence of neoplastic lesions (adenoma, advanced adenoma, and cancer) between individuals with and those without diverticula was compared. A multivariate analysis was performed.Results Overall, data from 970 consecutive individuals were evaluated, and diverticulosis was detected in 354 (36.5%) cases. At least one adenoma was detected in 490 (50.5%) people, at least one advanced adenoma in 264 (27.2%), multiple adenoma in 71 (7.3%), whilst a cancer was diagnosed in 48 (4.9%) cases. At univariate analysis, the adenoma detection rate in patients with diverticula was significantly higher than in controls (55.9% vs 47.4%; p=0.011). At multivariate analysis, presence of diverticulosis was an independent risk factor for both adenoma detection rate (OR=1.58; 95% CI=1.14-2.18; p=0.006) and advanced adenoma (OR=1.57; 95% CI=1.10-2.24; p=0.013), but not for colorectal cancer.Conclusions In a colorectal screening setting, the adenoma detection rate was significantly higher in individuals with diverticulosis than in controls

On generalised canonical axial waveguides

The dynamic behaviour of the class of periodic phononic waveguides whose unit cells are generated through a quasicrystalline sequence can be interpreted geometrically in terms of a trace map that embodies the recursive rule obeyed by traces of the transmission matrices. It has been recently shown [1,2] that for a canonical waveguide, the orbits predicted by the trace map at specific frequencies, called canonical frequencies, are periodic onto a surface in a 3D space associated with the invariant of the problem. In this talk, we extend the concept of canonical phononic axial waveguide to generalised Fibonacci sequences and show specific behaviours of the canonical configurations for the so-called silver-mean sequence. We explore various kind of periodic orbits for the trace map associated with different self-similar properties of the stop/pass band layout. The obtained results represent both a key to a better understanding of the dynamic properties of classical two-phase composite waveguides and an important advancement towards the realisation of composite quasicrystalline metamaterials

Fatal poisoning of four workers in a farm: Distribution of hydrogen sulfide and thiosulfate in 10 different biological matrices

We evaluate the distribution of sulfide and thiosulfate (TS) in biological samples of four dairy farmers died inside a pit connected to a manure lagoon. Autopsies were performed 4 days later. Toxicological analyses of sulfide and TS were made using an extractive alkylation technique combined with gas chromatography/mass spectrometry (GC/MS). Autopsies revealed: multiorgan congestion; pulmonary edema; manure inside distal airways of three of the four victims. Sulfide concentrations were cardiac blood: 0.5–3.0 μg/mL, femoral blood: 0.5–1.2 μg/mL, bile: <0.1–2.2 μg/mL; liver 2.8–8.3 μg/g, lung: 5.0–9.4 μg/g, brain: 2.7–13.9 μg/g, spleen: 3.3–6.3 μg/g, fat: <0.1–1.5 μg/g, muscle: 2.6–3.5 μg/g. TS concentrations were cardiac blood: 2.1–4.9 μg/mL, femoral blood: 2.1–2.3 μg/mL, bile: 2.5–4.4 μg/mL, urine: <0.5–1.8 μg/mL; liver <0.5–2.6, lung: 2.8–5.4 μg/g, brain: <0.5–1.9 μg/g, spleen: 1.2–2.9 μg/g, muscle: <0.5–5.6 μg/g. The cause of death was assessed to be acute poisoning by hydrogen sulfide (H2S) for all the victims. Manure inhalation contributed to the death of three subjects. The measurement of sulfide and TS concentrations in biological samples contributed to better understand the sequence of the events. Subjects 3 provided the highest concentration of sulfide in brain, thus, supporting the hypothesis of a rapid loss of consciousness and respiratory depression. One by one, the other farmers entered the pit in attempts to rescue the coworkers but collapsed. Despite the rapid death, subject 3 was the only one with TS detectable in urine. This could be due to differences in metabolism of H2S

BeppoSAX Observations of the Radio Galaxy Centaurus A

We present preliminary results from two observations of the radio galaxy Centaurus A performed by the BeppoSAX satellite. We did not detect any spectral variation of the nuclear continuum in spite of the long-term flux change (by a factor 1.3) between the two observations. At both epochs, the nuclear point-like emission was well fitted with a strongly absorbed power law with an exponential cutoff at high energies (E_cutoff>200 keV). We also observed a significant flux variation of the iron line between the two observations. The flux of the line and of the continuum changed in the opposite sense. The line is more intense at the first epoch, when the nuclear source was at the lower intensity level. The implied delay between the continuum and line variations strongly suggests that the cold material responsible for the iron line production is not located very near to the primary X-ray source. There is also evidence that the line profile changed between the two epochs, being broader and slightly blueshifted when the source was fainter. It is possible that the emission feature is a blend of cold and ionized iron lines produced in separate regions surrounding the nuclear source.Comment: 4 pages, 4 figures, accepted for publication in Advances in Space Research, proceedings of 32nd COSPAR Symposium (1998

Silver-mean canonical quasicrystalline-generated phononic waveguides

We investigate propagation of harmonic axial waves in a class of periodic two-phase phononic rods whose elementary cells are designed adopting the quasicrystalline silver mean Fibonacci substitution rule. The stop-/pass-band spectra of this family are studied with the aid of a trace-map formalism which provides a geometrical interpretation of the recursive rule governing traces of the relevant transmission matrices: the traces of two consecutive elementary cells can be represented as a point on a surface defined by an invariant function of the circular frequency, and the recursivity implies the description of an orbit on the surface. We show that, for a sub-class of silver mean-generated waveguides, the orbits predicted by the trace map at specific frequencies are periodic. The configurations for which this occurs, called canonical, are also associated with periodic stop-/pass-band diagrams along the frequency domain. Several types of periodic orbits exist and each corresponds to a self-similar portion of the dynamic spectra whose scaling law can be studied by linearising the trace map in the neighbourhood of the orbit. The obtained results provide both a new piece of theory to better understand the behaviour of classical two-phase composite periodic waveguides and an important advancement towards design and realisation of phononic quasicrystalline-based metamaterials

Natural cases of polyarthritis associated with feline calicivirus infection in cats

The limping syndrome is occasionally reported during acute feline calicivirus (FCV) infections or as consequence of vaccination. In this retrospective study, three clinical cases of lameness in household cats naturally infected by FCV were described and phylogeny of the virus were investigated by analysing the hypervariable E region of the ORF2 viral gene. Cats were diagnosed with polyarthritis and FCV RNA or antigens were detected in symptomatic joints. One cat, euthanized for ethical reasons, underwent a complete post-mortem examination and was subjected to histopathological and immunohistochemical investigations. No phylogenetic subgrouping were evident for the sequenced FCV. Histopathology of the euthanized cat revealed diffuse fibrinous synovitis and osteoarthritis eight months after the onset of lameness and the first detection of FCV RNA, supporting the hypothesis of a persistent infection. FCV was demonstrated by immunohistochemistry in synoviocytes and fibroblasts of the synovial membranes. This study provides new data on the occurrence of polyarthritis in FCV-infected cats, demonstrates by immunohistochemistry the presence of FCV in the synovial membranes of a cat with persistent polyarthritis and supports the absence of correlation between limping syndrome and phylogenetic subgrouping of viruses

Perforated duodenal ulcer in a dog with gallbladder agenesis

Background: Duodenal ulceration (DU) in dogs derives from different causes but has never previously been related to gallbladder agenesis (GA). GA is a rare congenital disorder in dogs and is considered a predisposing factor for DU in humans. Case description: A 5-month-old intact female Maltese was presented for acute vomiting and diarrhea. Abdominal ultrasound suggested duodenal perforation and absence of the gallbladder. Exploratory laparotomy was performed to treat the perforation and confirmed GA. Hepatic ductal plate malformation (DPM) was histologically diagnosed in liver biopsy, but no signs of liver dysfunction were detected by blood work at first admission. Two months later, the dog developed signs of portal hypertension and medical treatment was started. However, the clinical condition gradually worsened until liver failure and the dog was euthanized 8 months after surgery. Necropsy confirmed hepatic abnormalities. Conclusion: This report describes a case of DU associated with GA and DPM in a dog. As in humans, GA may represent a hepatobiliary disease predisposing to gastroduodenal ulcerations

A second order minimality condition for the Mumford-Shah functional

A new necessary minimality condition for the Mumford-Shah functional is derived by means of second order variations. It is expressed in terms of a sign condition for a nonlocal quadratic form on $H^1_0(\Gamma)$, $\Gamma$ being a submanifold of the regular part of the discontinuity set of the critical point. Two equivalent formulations are provided: one in terms of the first eigenvalue of a suitable compact operator, the other involving a sort of nonlocal capacity of $\Gamma$. A sufficient condition for minimality is also deduced. Finally, an explicit example is discussed, where a complete characterization of the domains where the second variation is nonnegative can be given.Comment: 30 page