Jobs on the Web for Brazilian professionals on information and-documentation: analysis of competencies and skills required by companies and institutions

Analisam-se as características de ofertas de emprego do setor da Informação-Documentação. A mostra foi obtida de anúncios na Internet feitos por empresas e instituições privadas brasileiras, durante o ano de 2010. A atividade foi realizada no âmbito de pesquisa maior que tem como objetivo geral construir uma taxonomia que classifique e hierarquize as competências e conhecimentos exigidos pelas empresas, bem como as características dos postos ofertados. Extraiu-se informação de 200 ofertas de emprego obtidas nos portais Catho: http://www.catho.com.br/ e Portal do bibliotecário: http://www.portalbibliotecario.com.br/. Cada entrada foi mantida em seu contexto de incidência e com a expressão original. Os termos obtidos passaram por um processo de normalização. A análise atende a classificar e valorar as atividades, conhecimentos e tarefas mais solicitados; assim como as aptidões, competências e habilidades; e as Incidências das unidades e dos profissionais de informação.The characteristics of employment offers in the Information-Documentation segment are analyzed. The sample was obtained from advertisements of Brazilian companies and private institutions in the Internet during the year 2010. The activity was part of a larger research which has as its main objective the construction of a taxonomy to classify and hierarchy the competences and knowledge demanded by the companies, as well as the characteristics of the offered positions. The information was extracted from 200 job offerings obtained in the portals Catho: http://www.catho.com.br/ and Portal do bibliotecário: http://www.portalbibliotecario.com.br/. Each entry was maintained in its incidence context and with its original expression. The terms passed by a standardization process. The analysis answers to the following classifications: more demanded activities, knowledge and tasks, aptitudes, competences and abilities, besides the incidence of units and of information professionals

A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans

During infection with the hepatitis A virus (HAV), most patients develop mild or asymptomatic disease. However, a small number of patients develop serious, life-threatening hepatitis. We investigated this variability in disease severity by examining 30 Argentinean patients with HAV-induced acute liver failure in a case-control, cross-sectional, observational study. We found that HAV-induced severe liver disease was associated with a 6-amino-acid insertion in TIM1/HAVCR1 (157insMTTTVP), the gene encoding the HAV receptor. This polymorphism was previously shown to be associated with protection against asthma and allergic diseases and with HIV progression. In binding assays, the TIM-1 protein containing the 157insMTTTVP insertion polymorphism bound HAV more efficiently. When expressed by human natural killer T (NKT) cells, this long form resulted in greater NKT cell cytolytic activity against HAV-infected liver cells, compared with the shorter TIM-1 protein without the polymorphism. To our knowledge, the 157insMTTTVP polymorphism in TIM1 is the first genetic susceptibility factor shown to predispose to HAV-induced acute liver failure. Furthermore, these results suggest that HAV infection has driven the natural selection of shorter forms of the TIM-1 protein, which binds HAV less efficiently, thereby protecting against severe HAV-induced disease, but which may predispose toward inflammation associated with asthma and allergy