Diagnosis Of Secondary Caries In Esthetic Restorations: Influence Of The Incidence Vertical Angle Of The X-ray Beam

The aim of this study was to evaluate the accuracy on the diagnosis of secondary caries-like lesions simulated on esthetic restorations of different materials, changing the incidence vertical angle (IVA) of the x-ray beam. Twenty human teeth received MOD inlay preparations. In the experimental group (n=10), a round cavity was made in the floor of the proximal box to simulate the caries-like lesion. All teeth were restored with 3 composite resins (Charisma, Filtek-Z250 and TPH-Spectrum) at 3 moments. Two radiographic images were acquired with 0° and 10° IVA. Ten observers evaluated the images using a 5-point confidence scale. Intra- and interobserver reliability was analyzed with the Interclass Correlation Coefficient and the diagnostic accuracy was evaluated using the area under the ROC curve (Az), Friedman test and Wilcoxon test (α=0.05). Higher accuracy values were obtained with 10° IVA (Az=0.66, Filtek- Z250>Az=0.56, TPH-Spectrum) compared to 0° (Az=0.55, Charisma>Az=0.37, TPH-Spectrum), though without statistically significant difference (p>0.05). The detection of secondary caries-like lesions simulated on esthetic restorations of different materials suffered no negative influence by changing the IVA of the x-ray beam.222129133Levin, L., Coval, M., Geiger, S.B., Cross-sectional radiographic survey of amalgam and resin-based composite posterior restorations (2007) Quintessence Int, 38, pp. 511-514Haak, R., Wicht, M.J., Hellmich, M., Noack, M.J., Detection of marginal defects of composite restorations with conventional and digital radiographs (2002) Eur J Oral Sci, 110, pp. 282-286Kirkevang, L.L., Vaeth, M., Wenzel, A., Prevalence and incidence of caries lesions in relation to placement and replacement of fillings: A longitudinal observational radiographic study of an adult Danish population (2009) Caries Res, 43, pp. 286-293Newman, B., Seow, W.K., Kazoullis, S., Ford, D., Holcombe, T., Clinical detection of caries in the primary dentition with and without bitewing radiography (2009) Austr Dent J, 54, pp. 23-30Anbiaee, N., Mohassel, A.R., Imanimoghaddam, M., Moazzami, S.M., A comparison of the accuracy of digital and conventional radiography in the diagnosis of recurrent caries (2010) Contemp Dent Pract, 11, pp. 25-32Nair, M.K., Tyndall, D.A., Ludlow, J.B., May, K., Ye, F., The effects of restorative material and location on the detection of simulated recurrent caries. A comparison of dental film, direct digital radiography and tuned aperture computed tomography (1998) Dentomaxillofac Radiol, 27, pp. 80-84van der Stelt, P.F., Ruttiman, U.E., Webber, R.L., Heemstra, P., In vitro study into the influence from x-ray beam angulation on the detection of artificial caries defects on interproximal radiographs (1989) Caries Res, 23, pp. 334-341Tveit, A.B., Espelid, I., Erickson, R.L., Glasspoole, E.A., Vertical angulation from X-ray beam and radiographic diagnosis of secondary caries (1991) Community Dent Oral Epidemiol, 19, pp. 333-335Akarslan, Z.Z., Akdevelioǧlu, M., Güngör, K., Erten, H., A comparison of the diagnostic accuracy of bitewing, periapical, unfiltered and filtered digital panoramic images for approximal caries detection in posterior teeth (2008) Dentomaxillofac Radiol, 37, pp. 458-463Sabbagh, J., Vreven, J., Leloup, G., Radiopacity of resin-based materials measured in film radiographs and storage phosphor plate (Digora) (2004) Oper Dent, 29, pp. 677-684Dental resin based restorative materials, 6 (10), pp. 1985-1985. , ISO:DP 4049, International standards organization (Draft Proposal), clauseMagalhães, C.S., Freitas, A.B., Moreira, A.N., Ferreira, E.F., Validity of staining and marginal ditching as criteria for diagnosis of secondary caries around occlusal amalgam restorations: An in vitro study (2009) Braz Dent J, 20, pp. 307-313Ergücü, Z., Türkün, L.S., Onem, E., Güneri, P., Comparative radiopacity of six flowable resin composites (2010) Oper Dent, 35, pp. 436-440Lasko, T.A., Bhagwat, J.G., Zou, K.H., Ohno-Machado, L., The use of receiver operating characteristic curves in biomedical informatics (2005) J Biomed Inform, 38, pp. 404-415Diniz, M.B., Rodrigues, J.A., Neuhaus, K.W., Cordeiro, R.C., Lussi, A., Influence of examiner's clinical experience on the reproducibility and accuracy of radiographic examination in detecting occlusal caries (2010) Clin Oral Investig, 14, pp. 515-523Zoellner, A., Diemer, B., Weber, H.P., Stassinakis, A., Gaengler, P., Histologic and radiographic assessment of caries-like lesions localized at the crown margin (2002) J Prosthet Dent, 88, pp. 54-59Ferreira, R.I., Haiter-Neto, F., Tabchoury, C.P., de Paiva, G.A., Bóscolo, F.N., Assessment of enamel demineralization using conventional, digital, and digitized radiography (2006) Braz Oral Res, 20, pp. 114-119Peker, I., Toraman Alkurt, M., Altunkaynak, B., Film tomography compared with film and digital bitewing radiography for proximal caries detection (2007) Dentomaxillofac Radiol, 36, pp. 495-49

Deletion of kinin B2 receptor alters muscle metabolism and exercise performance

Metabolic syndrome is a cluster of metabolic risk factors such as obesity, diabetes and cardiovascular diseases. Mitochondria is the main site of ATP production and its dysfunction leads to decreased oxidative phosphorylation, resulting in lipid accumulation and insulin resistance. Our group has demonstrated that kinins can modulate glucose and lipid metabolism as well as skeletal muscle mass. By using B2 receptor knockout mice (B2R-/-) we investigated whether kinin action affects weight gain and physical performance of the animals. Our results show that B2R-/- mice are resistant to high fat diet-induced obesity, have higher glucose tolerance as well as increased mitochondrial mass. These features are accompanied by higher energy expenditure and a lower feed efficiency associated with an increase in the proportion of type I fibers and intermediary fibers characterized by higher mitochondrial content and increased expression of genes related to oxidative metabolism. Additionally, the increased percentage of oxidative skeletal muscle fibers and mitochondrial apparatus in B2R-/- mice is coupled with a higher aerobic exercise performance. Taken together, our data give support to the involvement of kinins in skeletal muscle fiber type distribution and muscle metabolism, which ultimately protects against fat-induced obesity and improves aerobic exercise performance

Consistency analysis of a nonbirefringent Lorentz-violating planar model

In this work analyze the physical consistency of a nonbirefringent Lorentz-violating planar model via the analysis of the pole structure of its Feynman propagators. The nonbirefringent planar model, obtained from the dimensional reduction of the CPT-even gauge sector of the standard model extension, is composed of a gauge and a scalar fields, being affected by Lorentz-violating (LIV) coefficients encoded in the symmetric tensor $\kappa_{\mu\nu}$. The propagator of the gauge field is explicitly evaluated and expressed in terms of linear independent symmetric tensors, presenting only one physical mode. The same holds for the scalar propagator. A consistency analysis is performed based on the poles of the propagators. The isotropic parity-even sector is stable, causal and unitary mode for $0\leq\kappa_{00}<1$. On the other hand, the anisotropic sector is stable and unitary but in general noncausal. Finally, it is shown that this planar model interacting with a $\lambda|\varphi|^{4}-$Higgs field supports compactlike vortex configurations.Comment: 11 pages, revtex style, final revised versio

Major role of nutrient supply in the control of picophytoplankton community structure.

abstractThe Margalef´s mandala (1978) is a simplified bottom-up control model that explains how mixing and nutrient concentration determine the composition of marine phytoplankton communities. Due to the difficulties of measuring turbulence in the field, previous attempts to verify this model have applied different proxies for nutrient supply, and very often used interchangeably the terms mixing and stratification. Moreover, because the mandala was conceived before the discovery of smaller phytoplankton groups (picoplankton <2 μm), it describes only the succession of vegetative phases of microplankton. In order to test the applicability of the classical mandala to picoplankton groups, we used a multidisciplinary approach including specifically designed field observations supported by remote sensing, database analyses, and modeling and laboratory chemostat experiments. Simultaneous estimates of nitrate diffusive fluxes, derived from microturbulence observations, and picoplankton abundance collected in more than 200 stations, spanning widely different hydrographic regimes, showed that the contribution of eukaryotes to picoautotrophic biomass increases with nutrient supply, whereas that of picocyanobacteria shows the opposite trend. These findings were supported by laboratory and modeling chemostat experiments that reproduced the competitive dynamics between picoeukaryote sand picocyanobacteria as a function of changing nutrient supply. Our results indicate that nutrient supply controls the distribution of picoplankton functional groups in the ocean, further supporting the model proposed by Margalef.RADIALES (IEO