4 research outputs found
The onset and duration of mobilization affect the regeneration in the rat muscle
The effects of different mobilization
protocols for muscle regeneration after myotoxin injury
was compared in the rat tibialis anterior (TA) muscle.
Adult Wistar rats were divided into control (C);
mobilized (M); injury (I); injury + late mobilization
(LM) and injury + early mobilization (EM) groups.
Muscle injury was induced by intramuscular lidocaine
injection. The exercised animals were mobilized for 5
and 8 days during 15 and 45 minutes/session. The
swimming started 1 hour or 3 days after injury. All
animals were killed 8 days after the injury, together with
the control group, when the TA muscles were weighted
and excised. Cross sections were obtained by cryostat
and submitted to Toluidine Blue stain. Qualitative
morphological characterization of muscle regeneration
and quantitative analysis of muscle fiber and non-muscle
fiber area density were performed. The I and late
mobilization groups showed decreased muscle mass
when compared to all other groups. All injured animals
showed signs of muscle fiber damage, although signs of
early regenerated muscle fibers were more evident in
injury + mobilization groups. Only the EM groups
submitted to 45 minutes of exercise had increased
muscle fiber and decreased non-muscle fiber area
density values when compared to I group (p<0.05).
Conclusion: the regeneration process is related to the
onset of exercise, since animals submitted to early
mobilization showed improved regeneration when
comparted to LM groups. Besides, the length of session
is also important for accelerating the regeneration
process, as it was observed that 45 minutes was better
than 15 minutes duration
New Reference Values For Maximal Respiratory Pressures In The Brazilian Population: Corrections [novos Valores De Referência Para Pressões Respiratórias Máximas Na População Brasileira: Correções]
[No abstract available]365667Costa, D., Gonçalves, H.A., de Lima, L.P., Ike, D., Cancelliero, K.M., Montebelo, M.I., New reference values for maximal respiratory pressures in the Brazilian population (2010) J Bras Pneumol, 36 (3), pp. 306-31