3,037 research outputs found
On the Nature of the Cosmological Constant Problem
General relativity postulates the Minkowski space-time to be the standard
flat geometry against which we compare all curved space-times and the
gravitational ground state where particles, quantum fields and their vacuum
states are primarily conceived. On the other hand, experimental evidences show
that there exists a non-zero cosmological constant, which implies in a deSitter
space-time, not compatible with the assumed Minkowski structure. Such
inconsistency is shown to be a consequence of the lack of a application
independent curvature standard in Riemann's geometry, leading eventually to the
cosmological constant problem in general relativity.
We show how the curvature standard in Riemann's geometry can be fixed by
Nash's theorem on locally embedded Riemannian geometries, which imply in the
existence of extra dimensions. The resulting gravitational theory is more
general than general relativity, similar to brane-world gravity, but where the
propagation of the gravitational field along the extra dimensions is a
mathematical necessity, rather than being a a postulate. After a brief
introduction to Nash's theorem, we show that the vacuum energy density must
remain confined to four-dimensional space-times, but the cosmological constant
resulting from the contracted Bianchi identity is a gravitational contribution
which propagates in the extra dimensions. Therefore, the comparison between the
vacuum energy and the cosmological constant in general relativity ceases to be.
Instead, the geometrical fix provided by Nash's theorem suggests that the
vacuum energy density contributes to the perturbations of the gravitational
field.Comment: LaTex, 5 pages no figutres. Correction on author lis
Reoperation for persistent or recurrent secondary hyperparathyroidism
Background: Secondary hyperparathyroidism is a common acquired disorder seen in chronic renal failure. Its pathophysiology is mainly due to hyperphosphatemia and vitamin D deficiency and resistance. When medical treatment fails, subtotal and total parathyroidectomy with autotransplantation are the standard procedures, although both are associated with high recurrence rates.Methods and Results: 4 patients experienced
persistence and 9 relapse. The first 4 were subjected to reoperation after 6 months for the persistence of symptoms due to the finding of a supernumerary adenomatous gland while the remaining patients at the reoperation showed in 5 cases 2 more glands in over thymic position, and 4 an hyperplasia of the residual glandular tissue. A classic cervicotomy was sufficient to remove the residual parathyroid in patients with persistent hyperparathyroidism. For cases of recurrent hyperparathyroidism it was enough a medial approach and sometimes lateral for the complete excision of the hyperplastic tissue. The advent of the intraoperative technique of parathyroid hormone dosage allowed a better performance of the surgical technique for the last 3 patients undergoing reoperation. After reoperation all patients had immediate regression of clinical symptoms with normalization of serum calcium and PTH levels. Conclusions: On the basis of these considerations, diagnostic imaging has a not negligible role because during the first intervention helps to have an idea of the possible location of the glands and thus to avoid the risk of recurrence and relapse due to ectopic or supernumerary tissue
Unravelling main- and side-chain motions in polymers with NMR spectroscopy and relaxometry: The case of polyvinyl butyral
Polyvinyl butyral (PVB) is an amorphous polymer employed in many technological applications. In order to highlight the relationships between macroscopic properties and dynamics at a microscopic level, motions of the main-chain and of the propyl side-chains were investigated between Tg − 288◦ C and Tg + 55◦ C, with Tg indicating the glass transition temperature. To this aim, a combination of solid state Nuclear Magnetic Resonance (NMR) methods was applied to two purposely synthesized PVB isotopomers: one fully protonated and the other perdeuterated on the side-chains.1 H time domain NMR and1 H field cycling NMR relaxometry experiments, performed across and above Tg, revealed that the dynamics of the main-chain corresponds to the α-relaxation associated to the glass transition, which was previously characterized by dielectric spectroscopy. A faster secondary relaxation was observed for the first time and ascribed to side-chains. The geometry and rate of motions of the different groups in the side-chains were characterized below Tg by2 H NMR spectroscopy
Hypertension and intrapericardial paraganglioma: an exceptional presentation of multiple endocrine neoplasia type IIA syndrome.
Feeding the brain: the importance of nutrients for brain functions and health
\u2018We are what we eat\u2019, said the philosopher Feuerbach. In fact, the quality of the food we eat affects our mind as well: the brain, which represents 2% of our body weight, consumes about 20% of the calories we eat each day. Follow a few rules could therefore help to feed properly our brain, so it works to the best of its ability. It is important to know properties of foods especially regarding their aminoacidic composition because aminoacids are components of neurotransmitters, molecules needed for brain transmission and function. It is also possible to choose specific food to prevent or support different diseases that affects nervous system
Simulations of the X-ray imaging capabilities of the Silicon Drift Detectors (SDD) for the LOFT Wide Field Monitor
The Large Observatory For X-ray Timing (LOFT), selected by ESA as one of the
four Cosmic Vision M3 candidate missions to undergo an assessment phase, will
revolutionize the study of compact objects in our galaxy and of the brightest
supermassive black holes in active galactic nuclei. The Large Area Detector
(LAD), carrying an unprecedented effective area of 10 m^2, is complemented by a
coded-mask Wide Field Monitor, in charge of monitoring a large fraction of the
sky potentially accessible to the LAD, to provide the history and context for
the sources observed by LAD and to trigger its observations on their most
interesting and extreme states. In this paper we present detailed simulations
of the imaging capabilities of the Silicon Drift Detectors developed for the
LOFT Wide Field Monitor detection plane. The simulations explore a large
parameter space for both the detector design and the environmental conditions,
allowing us to optimize the detector characteristics and demonstrating the
X-ray imaging performance of the large-area SDDs in the 2-50 keV energy band.Comment: Proceedings of SPIE, Vol. 8443, Paper No. 8443-210, 201
Neuropsychological performances, quality of life, and psychological issues in pediatric onset multiple sclerosis: a narrative review
Multiple sclerosis (MS) is primarily a disease diagnosed in young and middle-aged adults. Although MS is a rare condition in pediatric age, an increasing rate of patients is diagnosed under the age of 18. The disabling nature of the disease cannot be reduced only to physical symptoms. Several additional symptoms such as cognitive impairment, fatigue, and psychological symptoms are common features of pediatric MS. The reviewed literature suggests that, despite the lower physical disability, children and adolescents diagnosed with MS are vulnerable to cognitive impairment even in the early stage of the disease. The neuropsychological profile of pediatric MS may resemble that of adult MS, including an impairment in attention/information processing speed, learning, verbal, and visuospatial memory. However, cognitive difficulties in children and adolescents are more likely to involve also general intelligence and linguistic abilities, presumably due to patients’ younger age and cognitive growth stage. Cognitive difficulties, beyond physical disability and relapses, may have a considerable impact on learning and school achievement. Depression and fatigue are other highly prevalent disturbances in pediatric MS and may contribute to patients’ low functional outcomes. Overall, these manifestations may cause considerable functional impairment on daily activities and quality of life that may require individualized rehabilitative treatment and extensive psychosocial care. Additional neuropsychological research evaluating larger samples, using more homogenous methods, and exploring the role of MS treatment on cognitive and psychological development is required
Learning from the italian experience during covid-19 pandemic waves: Be prepared and mind some crucial aspects
COVID-19 pandemic has rapidly spread worldwide causing a serious challenge to the global medical community. Italy was struck hard during the first wave earlier this year and several weaknesses as well as general unpreparedness of the national healthcare system were acknowledged. Learning essential lessons from the past, we realized how implementing contingency response measures, human resources and social dynamics could have changed the outcome if promptly adopted. This review translates the previous experience into strategic actions that has to be considered when developing appropriate national and regional operational plans to respond to a pandemic
Liposome-Mediated Delivery Improves the Efficacy of Lisosan G against Retinopathy in Diabetic Mice
Nutraceuticals are natural substances whose anti-oxidant and anti-inflammatory properties may be used to treat retinal pathologies. Their efficacy is limited by poor bioavailability, which could be improved using nanocarriers. Lisosan G (LG), a fermented powder from whole grains, protects the retina from diabetic retinopathy (DR)-induced damage. For this study, we tested whether the encapsulation of LG in liposomes (LipoLG) may increase its protective effects. Diabetes was induced in mice via streptozotocin administration, and the mice were allowed to freely drink water or a water dispersion of two different doses of LG or of LipoLG. Electroretinographic recordings after 6 weeks showed that only the highest dose of LG could partially protect the retina from diabetes-induced functional deficits, while both doses of LipoLG were effective. An evaluation of molecular markers of oxidative stress, inflammation, apoptosis, vascular endothelial growth factor, and the blood–retinal barrier confirmed that the highest dose of LG only partially protected the retina from DR-induced changes, while virtually complete prevention was obtained with either dose of LipoLG. These data indicate that the efficacy of LG in contrasting DR is greatly enhanced by its encapsulation in liposomes and may lay the ground for new dietary supplements with improved therapeutic effects against DR
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