Biology of Sexual Dysfunction

Sexual activity is a multifaceted activity, involving complex interactions between the nervous system, the endocrine system, the vascular system and a variety of structures that are instrumental in sexual excitement, intercourse and satisfaction. Sexual function has three components i.e., desire, arousal and orgasm. Many sexual dysfunctions can be categorized according to the phase of sexual response that is affected. In actual clinical practice however, sexual desire, arousal and orgasmic difficulties more often than not coexist, suggesting an integration of phases. Sexual dysfunction can result from a wide variety of psychological and physiological causes including derangements in the levels of sex hormones and neurotrensmitters. This review deals with the biology of different phases of sexual function as well as implications of hormones and neurotransmitters in sexual dysfunctio

Stress Analysis of Prithvi Missil Wing Subjected to Aerodynamic Forces

The stress problem of Prithvi missile wing is investigated . The analysis is carried out by the finite element method by using the ASKA software package. Finite element analysis is carried out for pressure loading, and thermal loading arising from aerodynamic heating . The,analysis for pressure loading indicates that there is stress concentration at the wing root region results obtained for various cases of this loading are presented and discussed. The distortion of the wing produced by aerodynamic heating has also been displayed

A Report on the Preliminary design of Composite Cocured LCA Fin

A report on the preliminary design of composite cocured LCA fin is presented. A six spar structural configuration involving laminated carbon composite construction is employed in the design of torsion box. The design studies are carried out using a strength of materials based analysis. Three critical loading cases have been considered in the investigation. Results for various cases studied are presented and discussed

VALIDATION OF SODIUM NITROPRUSSIDE IN VISIBLE SPECTROPHOTOMETRIC DETERMINATION OF TRIPOLIDINE HYDROCHLORIDE

Objective: A simple and sensitive extractive visible spectrophotometric method is developed for the assay of triprolidine hydrochloride using sodium nitroprusside. Methods: Based on color development with amino groups, presence, which is basic, may be due to the formation of inner complex replacing H2O by the tertiary amino group present in the drug. Results: The colored products exhibit absorption λmax at 447 nm. Regression analysis of Beer–Lambert plots showed good correlation in the concentration ranges (40–240) μg/ml and correlation coefficients are 0.994. The Sandell’s sensitivities 2.6373×10−2 (1 mole cm−1) and molar absorptivity value are 1.1938×104 (g cm−2). Recovery studies are found to be 99.708–99.786. Conclusion: The method can be applied successfully for the estimation of the drug in the presence of other ingredients that are usually present in formulations

POTENTIAL OF BAJRA [PENNISETUM GLAUCUM (L.) R. BR.] IN HEALTH AND DISEASE

Bajra, also known as pearl millet, African millet or spiked millet, originated in Northern-Central Sahel of West Africa, was introduced 2500 years ago into Indian subcontinent. However, it is mentioned in Ayurvedic texts from 14th Century AD onwards as Nali under Truna dhanya or Kudhanya vargas. It is considered as a major source of Gluten free diet and is used in the management of Coeliac disease and other gluten allergy conditions worldwide. Indians are also including millet into their day to day diet in accordance with the global trend.  However the conditions of Gluten allergy and Coeliac disease are not common in Southern India. Hence, the necessity of Gluten free diet in South Indian Population is under question. It is hypothesized that excessive millet usage could be a reason behind thyroid dysfunction and goitre. Regular millet only diet may also lead to a nutrition deprived state in people who are not gluten sensitive. Ayurveda also emphasizes on avoidance of regular use of Kudhanyas. This review comprises different aspects of dietary inclusion of Bajra. The properties and usability of Bajra as a gluten free diet, utility of Bajra in populations which are not gluten allergic and the effects of Bajra on health and disease form the core of this review.

Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration

Following epithelial-mesenchymal transition, acquisition of avian trunk neural crest cell (NCC) polarity is prerequisite for directional delamination and migration, which in turn is essential for peripheral nervous system development. However, how this cell polarization is established and regulated remains unknown. Here we demonstrate that, using the RHOA biosensor in vivo and in vitro, the initiation of NCC polarization is accompanied by highly activated RHOA in the cytoplasm at the cell rear and its fluctuating activity at the front edge. This differential RHOA activity determines polarized NC morphology and motility, and is regulated by the asymmetrically localized RhoGAP Deleted in liver cancer (DLC1) in the cytoplasm at the cell front. Importantly, the association of DLC1 with NEDD9 is crucial for its asymmetric localization and differential RHOA activity. Moreover, NC specifiers, SOX9 and SOX10, regulate NEDD9 and DLC1 expression, respectively. These results present a SOX9/SOX10-NEDD9/DLC1-RHOA regulatory axis to govern NCC migratory polarization.published_or_final_versio

Gate Driver Circuit Design, PWM signal generation using FEZ Panda III and Arduino for Inverter

This paper presents the gate driver circuit design and PWM signal generation using FEZ panda III and Arduino boards for Inverter. FEZ panda III works on .net micro framework and all its programming, debugging features are available through Microsoft’s Visual studio whereas Arduino features are available through Arduino software. Inverters are used in various applications like in motor drives and solar and wind power applications. This paper is commenced by basic understanding of need of gate driver circuit for inverter and different types of PWM techniques for generating gate signals for inverter. Simulation of SPWM inverter in both open loop and closed loop operation is done and its respective gate voltage waveforms are studied and later hardware implementation of gate driver circuit using TLP250H IC is carried out and gate voltages at different duty cycles is studied with the help of FEZ Panda III and Arduino boards

Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis

Optic neuritis (ON) is associated with numerous immune-mediated inflammatory diseases, but 50% patients are ultimately diagnosed with multiple sclerosis (MS). Differentiating MS-ON from non-MS-ON acutely is challenging but important; non-MS ON often requires urgent immunosuppression to preserve vision. Using data from the United Kingdom Biobank we showed that combining an MS-genetic risk score (GRS) with demographic risk factors (age, sex) significantly improved MS prediction in undifferentiated ON; one standard deviation of MS-GRS increased the Hazard of MS 1.3-fold (95% confidence interval 1.07–1.55, P < 0.01). Participants stratified into quartiles of predicted risk developed incident MS at rates varying from 4% (95%CI 0.5–7%, lowest risk quartile) to 41% (95%CI 33–49%, highest risk quartile). The model replicated across two cohorts (Geisinger, USA, and FinnGen, Finland). This study indicates that a combined model might enhance individual MS risk stratification, paving the way for precision-based ON treatment and earlier MS disease-modifying therapy

Principles of meiotic chromosome assembly revealed in S. cerevisiae

During meiotic prophase, chromosomes organise into a series of chromatin loops emanating from a proteinaceous axis, but the mechanisms of assembly remain unclear. Here we use Saccharomyces cerevisiae to explore how this elaborate three-dimensional chromosome organisation is linked to genomic sequence. As cells enter meiosis, we observe that strong cohesin-dependent grid-like Hi-C interaction patterns emerge, reminiscent of mammalian interphase organisation, but with distinct regulation. Meiotic patterns agree with simulations of loop extrusion with growth limited by barriers, in which a heterogeneous population of expanding loops develop along the chromosome. Importantly, CTCF, the factor that imposes similar features in mammalian interphase, is absent in S. cerevisiae, suggesting alternative mechanisms of barrier formation. While grid-like interactions emerge independently of meiotic chromosome synapsis, synapsis itself generates additional compaction that matures differentially according to telomere proximity and chromosome size. Collectively, our results elucidate fundamental principles of chromosome assembly and demonstrate the essential role of cohesin within this evolutionarily conserved process