Evaluation of Diamond Dressing Effect on Workpiece Surface Roughness by Way of Analysis of Variance

Abstract: Wheel dressing is an important action in the grinding process. This paper reports on the comparative study of the performance of two types of diamond dresser tool measured in terms of ground surface roughness. For experiments were used two types of dressers, single point and multi-point diamond dresser. In addition to the dresser tool, the wheel dressing speed and dressing depth were taken into account as dressing variables. Cutting conditions were a constant; the results of dressing were observed for bearing steel 100Cr6. The experimental study was designed using an orthogonal array and experimental data were processed by the analysis-of-variance method (ANOVA). The results show that with a 95% confidence, dressing with a multi-point diamond tool results in a smoother ground surface than with a single point diamond tool. As expected, wheel dressing speed and dressing depth also have significant effects on surface roughness. However, wheel dressing speed is much more influential than dressing depth

Materials characterization part I: contact area of the Berkovich indenter for nanoindentation tests

This is the first of two papers associated with materials characterization methods based on hardness testing. This paper presents a method to determine the area function of the Berkovich indenter used in nanoindentation hardness tests. The geometry and hence projected area of the indenter is known to affect the force-displacement response of a material during the loading and unloading stages. It is therefore important that the projected area is accurately defined to ensure determination of correct material hardness values. It is shown that values for the projected area determined from numerical methods applied to experimental data differ from values predicted inversely from theory based on the assumption of perfect tip geometry. This difference is attributed principally to a blunting of the tip, presenting as a tip radius. A simulation of the nanoindentation hardness test system is developed using finite element modelling (FEM) methods. Solutions for a range of load indentation curves obtained from experiment with fused silica are determined from best fit analyses using the root mean square error objective function (RMSE). A linear regression method is subsequently developed and used to estimate the area function. A parametric study of simulation and experimental results has been completed to verify the FEM and to assess the influence of varying tip curvature on force-displacement response during the loading and unloading stages and is summarily reported. A new method of analysis for determination of area function is proposed for use with numerical-based simulations, which for the first time, accommodates variation in tip geometry and which is shown to deliver improved agreement with nanoindentation experimental results. The second paper will focus on the study of the tip geometry of the Vickers microindenter. © 2017 Springer-Verlag Londo

The Use of the Kinetic Theory of Gases to Simulate the Physical Situations on the Surface of Autonomously Moving Parts During Multi-Energy Vibration Processing.

The multi-energy vibration processing, namely the combination of different energies or forces acting on a free abrasive medium for grinding of metal parts, is becoming more used in finishing processes, in recent years. However, the complexity that is involved in the aforementioned process requires a careful look in the particularities of the process itself in general and the movement of the abrasive media, in particular. In this paper, the nature of the collective movement of abrasive granules between the independently oscillating surfaces of the reservoir and the processed parts is described. This study presents the dissipation of the kinetic energy of the granules in a pseudo-gas from the working medium granules. The motion of the medium granules near the part surface, which is caused by pseudo-waves initiated by vibrations of the working surfaces of the vibration machine reservoir, is demonstrated. Furthermore, the nature of the motion of the granules near the oscillating part surface is described. The analysis that is presented here permits the determination of metal removal quantity from the surface of the workpiece as a result of multi-agent group action of the vibrating reservoir surface and the processed part. The optimal conditions for the finishing process can be determined based on the analysis presented

Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain.

The purpose of this work was to assess the reproducibility of diffusion imaging, and in particular the apparent diffusion coefficient (ADC), intra-voxel incoherent motion (IVIM) parameters and diffusion tensor imaging (DTI) parameters, across multiple centres using clinically available protocols with limited harmonization between sequences. An ice-water phantom and nine healthy volunteers were scanned across fives centres on eight scanners (four Siemens 1.5T, four Philips 3T). The mean ADC, IVIM parameters (diffusion coefficient D and perfusion fraction f) and DTI parameters (mean diffusivity MD and fractional anisotropy FA), were measured in grey matter, white matter and specific brain sub-regions. A mixed effect model was used to measure the intra- and inter-scanner coefficient of variation (CV) for each of the five parameters. ADC, D, MD and FA had a good intra- and inter-scanner reproducibility in both grey and white matter, with a CV ranging between 1% and 7.4%; mean 2.6%. Other brain regions also showed high levels of reproducibility except for small structures such as the choroid plexus. The IVIM parameter f had a higher intra-scanner CV of 8.4% and inter-scanner CV of 24.8%. No major difference in the inter-scanner CV for ADC, D, MD and FA was observed when analysing the 1.5T and 3T scanners separately. ADC, D, MD and FA all showed good intra-scanner reproducibility, with the inter-scanner reproducibility being comparable or faring slightly worse, suggesting that using data from multiple scanners does not have an adverse effect compared with using data from the same scanner. The IVIM parameter f had a poorer inter-scanner CV when scanners of different field strengths were combined, and the parameter was also affected by the scan acquisition resolution. This study shows that the majority of diffusion MRI derived parameters are robust across 1.5T and 3T scanners and suitable for use in multi-centre clinical studies and trials

Alpha-particle-induced complex chromosome exchanges transmitted through extra-thymic lymphopoiesis in vitro show evidence of emerging genomic instability

Human exposure to high-linear energy transfer α-particles includes environmental (e.g. radon gas and its decay progeny), medical (e.g. radiopharmaceuticals) and occupational (nuclear industry) sources. The associated health risks of α-particle exposure for lung cancer are well documented however the risk estimates for leukaemia remain uncertain. To further our understanding of α-particle effects in target cells for leukaemogenesis and also to seek general markers of individual exposure to α-particles, this study assessed the transmission of chromosomal damage initially-induced in human haemopoietic stem and progenitor cells after exposure to high-LET α-particles. Cells surviving exposure were differentiated into mature T-cells by extra-thymic T-cell differentiation in vitro. Multiplex fluorescence in situ hybridisation (M-FISH) analysis of naïve T-cell populations showed the occurrence of stable (clonal) complex chromosome aberrations consistent with those that are characteristically induced in spherical cells by the traversal of a single α-particle track. Additionally, complex chromosome exchanges were observed in the progeny of irradiated mature T-cell populations. In addition to this, newly arising de novo chromosome aberrations were detected in cells which possessed clonal markers of α-particle exposure and also in cells which did not show any evidence of previous exposure, suggesting ongoing genomic instability in these populations. Our findings support the usefulness and reliability of employing complex chromosome exchanges as indicators of past or ongoing exposure to high-LET radiation and demonstrate the potential applicability to evaluate health risks associated with α-particle exposure.This work was supported by the Department of Health, UK. Contract RRX95 (RMA NSDTG)

Cellular Radiosensitivity: How much better do we understand it?

Purpose: Ionizing radiation exposure gives rise to a variety of lesions in DNA that result in genetic instability and potentially tumorigenesis or cell death. Radiation extends its effects on DNA by direct interaction or by radiolysis of H2O that generates free radicals or aqueous electrons capable of interacting with and causing indirect damage to DNA. While the various lesions arising in DNA after radiation exposure can contribute to the mutagenising effects of this agent, the potentially most damaging lesion is the DNA double strand break (DSB) that contributes to genome instability and/or cell death. Thus in many cases failure to recognise and/or repair this lesion determines the radiosensitivity status of the cell. DNA repair mechanisms including homologous recombination (HR) and non-homologous end-joining (NHEJ) have evolved to protect cells against DNA DSB. Mutations in proteins that constitute these repair pathways are characterised by radiosensitivity and genome instability. Defects in a number of these proteins also give rise to genetic disorders that feature not only genetic instability but also immunodeficiency, cancer predisposition, neurodegeneration and other pathologies. Conclusions: In the past fifty years our understanding of the cellular response to radiation damage has advanced enormously with insight being gained from a wide range of approaches extending from more basic early studies to the sophisticated approaches used today. In this review we discuss our current understanding of the impact of radiation on the cell and the organism gained from the array of past and present studies and attempt to provide an explanation for what it is that determines the response to radiation

At work and play; business events as entrepreneurial spaces

There is inadequate literature examining, and illustrating, the integration of play and business events and how this facilitates entrepreneurial opportunities. Business events are distinct from the patterns of ordinary life and increasingly offer participants an ‘invitation to play’, encouraging socialization and trust. This article examines the role of play in the design of business events and how this can enable entrepreneurial outcomes. Through examination of diverse, but related, literature and three contrasting, empirically based, case studies, this article illustrates how event creators take an increasingly entrepreneurial approach. These cases range from a charity event with participants sleeping with the homeless on a city’s streets, a major flooring manufacturer designing events to outsource innovation and an imaginative event activity termed ‘coffee and papers’. Designing events that fuse, rather than polarize, play and work enables business event settings, and activities, which trigger entrepreneurial outcomes. This article adds to the embryonic literature and concludes by identifying four principles that underlie the effectual facilitation of play in a business event setting