2,693 research outputs found
Review of "Scaffolding in Tissue Engineering", by Peter X. Ma and Jennifer Elisseeff (Editors)
Agronomic performance of 27 cocoa progenies and plant selection based on productivity, self-compatibility and disease resistance
Thermodynamics of Holographic Defects
Using the AdS/CFT correspondence, we study the thermodynamic properties and
the phase diagram of matter fields on (2+1)-dimensional defects coupled to a
(3+1)-dimensional N=4 SYM "heat bath". Considering a background magnetic field,
(net) quark density, defect "magnitude" and the mass of the
matter, we study the defect contribution to the thermodynamic potentials and
their first and second derivatives to map the phases and study their physical
properties.
We find some features that are qualitatively similar to other systems e.g. in
(3+1) dimensions and a number of features that are particular to the defect
nature, such as its magnetic properties, unexpected properties at T->0 and
finite density; and the finite effects, e.g. a diverging
susceptibility and vanishing density of states at small temperatures, a
physically consistent negative heat capacity and new types of consistent
phases.Comment: 33 pages, 16 figures (jpg and pdf), typos fixed and references added,
final version published in JHE
Transforming growth factor beta-1 (TGFB1) and peak bone mass: association between intragenic polymorphisms and quantitative ultrasound of the heel
BACKGROUND: Variance of peak bone mass has a substantial genetic component, as has been shown with twin studies examining quantitative measures such as bone mineral density (BMD) and quantitative ultrasound (QUS). Evidence implicating single nucleotide polymorphisms (SNPs) of the transforming growth factor beta-1 (TGFB1) gene is steadily accumulating. However, a comprehensive look at multiple SNPs at this locus for their association with indices of peak bone mass has not been reported. METHODS: A cohort of 653 healthy Caucasian females 18 to 35 years old was genotyped for seven TGFB1 SNPs. Polymorphisms were detected by restriction endonuclease digestion of amplified DNA segments. RESULTS: The frequencies of the least common allele at G-800A, C-509T, codon 10 (L10P), codon 25 (R25P), codon 263 (T263I), C861-20T, and 713-8 delC loci were 0.07, 0.33, 0.41, 0.08, 0.04, 0.25 and 0.01, respectively. A significant association was seen between QUS Stiffness Index (QUS-SI) and the SNP at codon 10 and the linked promoter SNP, C-509T. This association remained significant after multiple regression was used to incorporate important clinical covariates – age, BMI, level of activity, family history, and caffeine intake – into the model. CONCLUSION: The association of QUS-SI with -509T is consistent with a gene-dose effect, while only individuals homozygous for the codon 10P allele showed a significant increase. In this cohort of young healthy Caucasian females, the T allele at position -509 is associated with greater bone mass as measured by calcaneal ultrasound
Light Stop Decay in the MSSM with Minimal Flavour Violation
In supersymmetric scenarios with a light stop particle and a
small mass difference to the lightest supersymmetric particle (LSP) assumed to
be the lightest neutralino, the flavour changing neutral current decay
can be the dominant decay channel and can
exceed the four-body stop decay for certain parameter values. In the framework
of Minimal Flavour Violation (MFV) this decay is CKM-suppressed, thus inducing
long stop lifetimes. Stop decay length measurements at the LHC can then be
exploited to test models with minimal flavour breaking through Standard Model
Yukawa couplings. The decay width has been given some time ago by an
approximate formula, which takes into account the leading logarithms of the MFV
scale. In this paper we calculate the exact one-loop decay width in the
framework of MFV. The comparison with the approximate result exhibits
deviations of the order of 10% for large MFV scales due to the neglected
non-logarithmic terms in the approximate decay formula. The difference in the
branching ratios is negligible. The large logarithms have to be resummed. The
resummation is performed by the solution of the renormalization group
equations. The comparison of the exact one-loop result and the tree level
flavour changing neutral current decay, which incorporates the resummed
logarithms, demonstrates that the resummation effects are important and should
be taken into account.Comment: 29 page
Intraoperative radiation therapy (IORT) for previously untreated malignant gliomas
BACKGROUND: Intraoperative radiation therapy (IORT) is one of the methods used to deliver a large single dose to the tumor tissue while reducing the exposure of normal surrounding tissue. However, the usefulness of intraoperative electron therapy for malignant gliomas has not been established. METHODS: During the period from 1987 to 1997, 32 patients with malignant gliomas were treated with IORT. The histological diagnoses were anaplastic astrocytoma in 11 patients and glioblastoma in 21 patients. Therapy consisted of surgical resection and intraoperative electron therapy using a dose of 12–15 Gy (median, 15 Gy). The patients later underwent postoperative external radiation therapy (EXRT) with a median total dose of 60 Gy. Each of the 32 patients treated with IORT was randomly matched with patients who had been treated with postoperative EXRT alone (control). Patients were matched according to histological grade, age, extent of tumor removal, and tumor location. RESULTS: In the anaplastic astrocytoma group, the one-, two- and five-year survival rates were 81%, 51% and 15%, respectively in the IORT patients and 54%, 43% and 21%, respectively in the control patients. In the glioblastoma group, one-, two- and five-year survival rates were 63%, 26% and 0%, respectively in the IORT patients and 70%, 18% and 6%, respectively in the control patients. There was no significant difference between survival rates in the IORT patients and control patients in either the anaplastic astrocytoma group or glioblastoma group. CONCLUSIONS: IORT dose not improve survival of patients with malignant gliomas compared to that of patients who have received EXRT alone
Schr\"odinger Holography with and without Hyperscaling Violation
We study the properties of the Schr\"odinger-type non-relativistic holography
for general dynamical exponent z with and without hyperscaling violation
exponent \theta. The scalar correlation function has a more general form due to
general z as well as the presence of \theta, whose effects also modify the
scaling dimension of the scalar operator. We propose a prescription for minimal
surfaces of this "codimension 2 holography," and demonstrate the (d-1)
dimensional area law for the entanglement entropy from (d+3) dimensional
Schr\"odinger backgrounds. Surprisingly, the area law is violated for d+1 < z <
d+2, even without hyperscaling violation, which interpolates between the
logarithmic violation and extensive volume dependence of entanglement entropy.
Similar violations are also found in the presence of the hyperscaling
violation. Their dual field theories are expected to have novel phases for the
parameter range, including Fermi surface. We also analyze string theory
embeddings using non-relativistic branes.Comment: 62 pages and 6 figures, v2: several typos in section 5 corrected,
references added, v3: typos corrected, references added, published versio
Iridium wire grid polarizer fabricated using atomic layer deposition
In this work, an effective multistep process toward fabrication of an iridium wire grid polarizer for UV applications involving a frequency doubling process based on ultrafast electron beam lithography and atomic layer deposition is presented. The choice of iridium as grating material is based on its good optical properties and a superior oxidation resistance. Furthermore, atomic layer deposition of iridium allows a precise adjustment of the structural parameters of the grating much better than other deposition techniques like sputtering for example. At the target wavelength of 250 nm, a transmission of about 45% and an extinction ratio of 87 are achieved
A fresh look at the evolution and diversification of photochemical reaction centers
In this review, I reexamine the origin and diversification of photochemical reaction centers based on the known phylogenetic relations of the core subunits, and with the aid of sequence and structural alignments. I show, for example, that the protein folds at the C-terminus of the D1 and D2 subunits of Photosystem II, which are essential for the coordination of the water-oxidizing complex, were already in place in the most ancestral Type II reaction center subunit. I then evaluate the evolution of reaction centers in the context of the rise and expansion of the different groups of bacteria based on recent large-scale phylogenetic analyses. I find that the Heliobacteriaceae family of Firmicutes appears to be the earliest branching of the known groups of phototrophic bacteria; however, the origin of photochemical reaction centers and chlorophyll synthesis cannot be placed in this group. Moreover, it becomes evident that the Acidobacteria and the Proteobacteria shared a more recent common phototrophic ancestor, and this is also likely for the Chloroflexi and the Cyanobacteria. Finally, I argue that the discrepancies among the phylogenies of the reaction center proteins, chlorophyll synthesis enzymes, and the species tree of bacteria are best explained if both types of photochemical reaction centers evolved before the diversification of the known phyla of phototrophic bacteria. The primordial phototrophic ancestor must have had both Type I and Type II reaction centers
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