66 research outputs found
Discovery of a Supernova Explosion at Half the Age of the Universe and its Cosmological Implications
The ultimate fate of the universe, infinite expansion or a big crunch, can be
determined by measuring the redshifts, apparent brightnesses, and intrinsic
luminosities of very distant supernovae. Recent developments have provided
tools that make such a program practicable: (1) Studies of relatively nearby
Type Ia supernovae (SNe Ia) have shown that their intrinsic luminosities can be
accurately determined; (2) New research techniques have made it possible to
schedule the discovery and follow-up observations of distant supernovae,
producing well over 50 very distant (z = 0.3 -- 0.7) SNe Ia to date. These
distant supernovae provide a record of changes in the expansion rate over the
past several billion years. By making precise measurements of supernovae at
still greater distances, and thus extending this expansion history back far
enough in time, we can distinguish the slowing caused by the gravitational
attraction of the universe's mass density Omega_M from the effect of a possibly
inflationary pressure caused by a cosmological constant Lambda. We report here
the first such measurements, with our discovery of a Type Ia supernova (SN
1997ap) at z = 0.83. Measurements at the Keck II 10-m telescope make this the
most distant spectroscopically confirmed supernova. Over two months of
photometry of SN 1997ap with the Hubble Space Telescope and ground-based
telescopes, when combined with previous measurements of nearer SNe Ia, suggests
that we may live in a low mass-density universe. Further supernovae at
comparable distances are currently scheduled for ground and space-based
observations.Comment: 12 pages and 4 figures (figure 4 is repeated in color and black and
white) Nature, scheduled for publication in the 1 January, 1998 issue. Also
available at http://www-supernova.lbl.go
TLR2 and Nod2 Mediate Resistance or Susceptibility to Fatal Intracellular Ehrlichia Infection in Murine Models of Ehrlichiosis
Our murine models of human monocytic ehrlichiosis (HME) have shown that severe and fatal ehrlichiosis is due to generation of pathogenic T cell responses causing immunopathology and multi-organ failure. However, the early events in the liver, the main site of infection, are not well understood. In this study, we examined the liver transcriptome during the course of lethal and nonlethal infections caused by Ixodes ovatus Ehrlichia and Ehrlichia muris, respectively. On day 3 post-infection (p.i.), although most host genes were down regulated in the two groups of infected mice compared to naïve counterparts, lethal infection induced significantly higher expression of caspase 1, caspase 4, nucleotide binding oligomerization domain-containing proteins (Nod1), tumor necrosis factor-alpha, interleukin 10, and CCL7 compared to nonlethal infection. On day 7 p.i., lethal infection induced highly significant upregulation of type-1 interferon, several inflammatory cytokines and chemokines, which was associated with increased expression levels of Toll-like receptor-2 (TLR2), Nod2, MyD88, nuclear factor-kappa B (NF-kB), Caspase 4, NLRP1, NLRP12, Pycard, and IL-1β, suggesting enhanced TLR signals and inflammasomes activation. We next evaluated the participation of TLR2 and Nod2 in the host response during lethal Ehrlichia infection. Although lack of TLR2 impaired bacterial elimination and increased tissue necrosis, Nod2 deficiency attenuated pathology and enhanced bacterial clearance, which correlated with increased interferon-γ and interleukin-10 levels and a decreased frequency of pathogenic CD8+ T cells in response to lethal infection. Thus, these data indicate that Nod2, but not TLR2, contributes to susceptibility to severe Ehrlichia-induced shock. Together, our studies provide, for the first time, insight into the diversity of host factors and novel molecular pathogenic mechanisms that may contribute to severe HME. © 2013 Chattoraj et al
Respiratory potentials of the fish (Tilapia mossambica) under malathion, carbaryl and lindane intoxication
Significance of glucose-6-phosphate dehydrogenase activity in tissues of penaeid prawn,Metapenaeus monoceros (Fabricius) under acute kelthane exposure
Changes in selected biochemical parameters in the kidney and blood of the fish,Tilapia mossambica (Peters), exposed to heptachlor
Effects of xylazine–ketamine–diazepam anesthesia on blood cell counts and plasma biochemical values in sheep and goats
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