Wat als Rusland niet ratificeert?

Russian ratification of the Kyoto Protocol (KP), vital for the KP to enter into force, is still uncertain. This report evaluates a number of options to save the KP in case no Russian ratification takes place in the foreseeable future. It shows that some of these alternatives may be environmentally more effective than in the case of the present KP, due to the amount of surplus emissions (hot air) avoided when Russia does not participate. They could also result in more Clean Development Mechanisms (CDM) revenues for developing countries, without leading to higher costs for the participating industrial countries. However, both setting up an alternative framework outside the KP and amending the KP raise legal and practical problems that pose serious obstacles for preserving the KP without Russian participation. The best way to stimulate Russian ratification seems highlighting the economic and political gains of ratification, and - if needed - linking the issue of ratification to other issues, such as Russian membership of the World Trade Organisation. By involving policy makers at the highest level (i.e. heads of state) a political deal might thus be reached.Ratificatie van het Kyoto Protocol (KP) door Rusland, noodzakelijk voor de inwerkingtreding van het Kyoto Protocol, is nog steeds onzeker. Dit rapport evalueert een aantal opties voor behoud van het KP in het geval Rusland niet (op afzienbare termijn) ratificeert. Het rapport laat zien dat de milieu-effectiviteit van sommige alternatieven beter is dan het huidige KP door de hoeveelheid surplus emissieruimte (hot air) die wordt vermeden als Rusland niet ratificeert. Tegelijkertijd leiden sommige alternatieven tot meer inkomsten uit CDM (Clean Development Mechanisms) voor ontwikkelingslanden, zonder dat dit resulteert in veel hogere kosten voor de (deelnemende) industrielanden. Echter, in alle gevallen vormen de juridische en practische problemen die samenhangen met het opzetten van een alternatief juridische raamwerk of amendering van het KP, een groot obstakel voor het behouden van het KP zonder Rusland. De beste manier om Russische ratificatie te bewerkstelligen lijkt het benadrukken van de politieke en economische voordelen van ratificatie en - zo nodig - ratificatie te koppelen aan andere vraagstukken zoals toetreding van Rusland tot de wereldhandelsorganisatie. Middels de betrokkenheid van beleidsmakers op het hoogste niveau (staatshoofden) kan dan wellicht tot een politieke deal worden gekomen

Tissue biopsy for the diagnosis of amyloidosis: experience from some centres

A reliable diagnosis of amyloidosis is usually based on a tissue biopsy. With increasing options for specific treatments of the different amyloid diseases, an exact and valid diagnosis including determination of the biochemical fibril nature is imperative. Biopsy sites as well as amyloid typing principles vary and this paper describes methods employed at some laboratories specialised in amyloidosis in Europe, Japan and USA

Examining a staging model for anorexia nervosa: empirical exploration of a four stage model of severity.

Background: An illness staging model for anorexia nervosa (AN) has received increasing attention, but assessing the merits of this concept is dependent on empirically examining a model in clinical samples. Building on preliminary findings regarding the reliability and validity of the Clinician Administered Staging Instrument for Anorexia Nervosa (CASIAN), the current study explores operationalising CASIAN severity scores into stages and assesses their relationship with other clinical features. Method: In women with DSM-IV-R AN and sub-threshold AN (all met AN criteria using DSM 5), receiver operating curve (ROC) analysis (n = 67) assessed the relationship between the sensitivity and specificity of each stage of the CASIAN. Thereafter chi-square and post-hoc adjusted residual analysis provided a preliminary assessment of the validity of the stages comparing the relationship between stage and treatment intensity and AN sub-types, and explored movement between stages after six months (Time 3) in a larger cohort (n = 171). Results: The CASIAN significantly distinguished between milder stages of illness (Stage 1 and 2) versus more severe stages of illness (Stages 3 and 4), and approached statistical significance in distinguishing each of the four stages from one other. CASIAN Stages were significantly associated with treatment modality and primary diagnosis, and CASIAN Stage at Time 1 was significantly associated with Stage at 6 month follow-up. Conclusions: Provisional support is provided for a staging model in AN. Larger studies with longer follow-up of cases are now needed to replicate and extend these findings and evaluate the overall utility of staging as well as optimal staging models

Reduction in Phencyclidine Induced Sensorimotor Gating Deficits in the Rat Following Increased System Xc − Activity in the Medial Prefrontal Cortex

Rationale: Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc −, a cystine–glutamate antiporter, is a poorly understood mechanism that contributes to both cellular antioxidant capacity and glutamate homeostasis. Objectives: Our goal was to determine whether increased system xc − activity within the prefrontal cortex would normalize a rodent measure of sensorimotor gating. Methods: In situ hybridization was used to map messenger RNA (mRNA) expression of xCT, the active subunit of system xc −, in the prefrontal cortex. Prepulse inhibition was used to measure sensorimotor gating; deficits in prepulse inhibition were produced using phencyclidine (0.3–3 mg/kg, sc). N-Acetylcysteine (10–100 μM) and the system xc − inhibitor (S)-4-carboxyphenylglycine (CPG, 0.5 μM) were used to increase and decrease system xc − activity, respectively. The uptake of 14C-cystine into tissue punches obtained from the prefrontal cortex was used to assay system xc − activity. Results: The expression of xCT mRNA in the prefrontal cortex was most prominent in a lateral band spanning primarily the prelimbic cortex. Although phencyclidine did not alter the uptake of 14C-cystine in prefrontal cortical tissue punches, intraprefrontal cortical infusion of N-acetylcysteine (10–100 μM) significantly reduced phencyclidine- (1.5 mg/kg, sc) induced deficits in prepulse inhibition. N-Acetylcysteine was without effect when coinfused with CPG (0.5 μM), indicating an involvement of system xc −. Conclusions: These results indicate that phencyclidine disrupts sensorimotor gating through system xc − independent mechanisms, but that increasing cystine–glutamate exchange in the prefrontal cortex is sufficient to reduce behavioral deficits produced by phencyclidine

Investor heterogeneity and the cross-section of U.K. investment trust performance

We use the upper and lower bounds derived by Ferson and Lin (2010) to examine the impact of investor heterogeneity on the performance of U.K. investment trusts relative to alternative linear factor models. We find using the upper bounds that investor heterogeneity has an important impact for nearly all investment trusts. The upper bounds are large in economic terms and significantly different from zero. We find no evidence of any trusts where all investors agree on the sign of performance beyond what we expect by chance. Using the lower bound, we find that trusts with a larger disagreement about trust performance have a weaker relation between the trust premium and past Net Asset Value (NAV) performance

A statistical study of gamma-ray burst afterglows measured by the Swift Ultraviolet Optical Telescope

We present the first statistical analysis of 27 Ultraviolet Optical Telescope (UVOT) optical/ultraviolet light curves of gamma-ray burst (GRB) afterglows. We have found, through analysis of the light curves in the observer's frame, that a significant fraction rise in the first 500 s after the GRB trigger, all light curves decay after 500 s, typically as a power law with a relatively narrow distribution of decay indices, and the brightest optical afterglows tend to decay the quickest. We find that the rise could be either produced physically by the start of the forward shock, when the jet begins to plough into the external medium, or geometrically where an off-axis observer sees a rising light curve as an increasing amount of emission enters the observers line of sight, which occurs as the jet slows. We find that at 99.8 per cent confidence, there is a correlation, in the observed frame, between the apparent magnitude of the light curves at 400 s and the rate of decay after 500 s. However, in the rest frame, a Spearman rank test shows only a weak correlation of low statistical significance between luminosity and decay rate. A correlation should be expected if the afterglows were produced by off-axis jets, suggesting that the jet is viewed from within the half-opening angle θ or within a core of a uniform energy density θc. We also produced logarithmic luminosity distributions for three rest-frame epochs. We find no evidence for bimodality in any of the distributions. Finally, we compare our sample of UVOT light curves with the X-ray Telescope (XRT) light-curve canonical model. The range in decay indices seen in UVOT light curves at any epoch is most similar to the range in decay of the shallow decay segment of the XRT canonical model. However, in the XRT canonical model, there is no indication of the rising behaviour observed in the UVOT light curves

Rapid quantification of myocardial fibrosis: a new macro-based automated analysis

Background: Fibrosis is associated with various cardiac pathologies and dysfunction. Current quantification methods are time-consuming and laborious. We describe a semi-automated quantification technique for myocardial fibrosis and validated this using traditional methods

Structural Diversity in Bacterial Ribosomes: Mycobacterial 70S Ribosome Structure Reveals Novel Features

Here we present analysis of a 3D cryo-EM map of the 70S ribosome from Mycobacterium smegmatis, a saprophytic cousin of the etiological agent of tuberculosis in humans, Mycobacterium tuberculosis. In comparison with the 3D structures of other prokaryotic ribosomes, the density map of the M. smegmatis 70S ribosome reveals unique structural features and their relative orientations in the ribosome. Dramatic changes in the periphery due to additional rRNA segments and extra domains of some of the peripheral ribosomal proteins like S3, S5, S16, L17, L25, are evident. One of the most notable features appears in the large subunit near L1 stalk as a long helical structure next to helix 54 of the 23S rRNA. The sharp upper end of this structure is located in the vicinity of the mRNA exit channel. Although the M. smegmatis 70S ribosome possesses conserved core structure of bacterial ribosome, the new structural features, unveiled in this study, demonstrates diversity in the 3D architecture of bacterial ribosomes. We postulate that the prominent helical structure related to the 23S rRNA actively participates in the mechanisms of translation in mycobacteria