Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study

Objectives Several studies focused on the association between alcohol consumption and amyotrophic lateral sclerosis (ALS), although with inconsistent findings. Antioxidants may play a role since lyophilised red wine was found to prolong SOD1 mice lifespan. The aim of this international population-based case-control study performed in Ireland, The Netherlands and Italy was to assess the role of alcohol, and red wine in particular, in developing ALS.Methods Euro-MOTOR is a case-control study where patients with incident ALS and controls matched for gender, age and area of residency were recruited in a population-based design. Logistic regression models adjusted for sex, age, cohort, education, leisure time physical activity, smoking, heart problems, hypertension, stroke, cholesterol and diabetes were performed.Results 1557 patients with ALS and 2922 controls were enrolled in the study. Exposure to alcohol drinking was not significantly associated with ALS risk. A stratified analysis of exposure to alcohol by cohort revealed significant ORs in The Netherlands and in Apulia, with opposite directions (respectively 0.68 and 2.38). With regard to red wine consumption, only in Apulia the double-fold increased risk (OR 2.53) remained significant. A decreased risk was found for current alcohol drinkers (OR 0.83), while a significantly increased risk was detected among former drinkers (OR 1.63). Analysis of cumulative exposure to alcohol revealed no significant associations with ALS risk.Conclusion With few exceptions, no significant association was found between alcohol consumption and ALS. The study of the association between alcohol and ALS requires a thorough exploration, especially considering the role of different type of alcoholic beverages

Subtropical Dry Forests: The Main Forest Ecoregion of Argentina

The Chaco is a sparsely populated, wooded grassland natural region of the Río de la Plata basin, where four physiognomic regions can be identified: Humid Chaco, Semi-arid Chaco, Arid Chaco, and Chaco Serrano. In this introduction to the section of subtropical dry forests, the most relevant tree genera and species are presented. A severe degradation and deforestation process characterize this region in the current century. The main productive systems are described, together with their effects on environmental, economic, and social aspects: extraction of firewood, production of charcoal, and extensive livestock. The recent advance of the agricultural frontier threatens the native communities living within and from the forest in an ancient equilibrium: changes in land use, technological advances of agriculture, increase of logging in the natural forest are occurring. A new tree-centered production paradigm is needed. “Quebracho” species represent a historical paradigm of overexploitation but a promise of possible sustainable management. Key species for the reconversion of the productive systems in the Chaco (not treated in the following chapters) are presented, taking into account their potential for breeding and relevance for restoration, within the environmental, economic, and social context of the region.Instituto de Fisiología y Recursos Genéticos VegetalesFil: Verga, Anibal. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja. Agencia De Extensión Rural La Rioja; ArgentinaFil: Lopez Lauenstein, Diego. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Fisiología y Recursos Genéticos Vegetales; ArgentinaFil: Lopez Lauenstein, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Estudios Agropecuarios (UDEA); Argentin