Anesthetic action on the transmission delay between cortex and thalamus explains the beta-buzz observed under propofol anesthesia

In recent years, more and more surgeries under general anesthesia have been performed with the assistance of electroencephalogram (EEG) monitors. An increase in anesthetic concentration leads to characteristic changes in the power spectra of the EEG. Although tracking the anesthetic-induced changes in EEG rhythms can be employed to estimate the depth of anesthesia, their precise underlying mechanisms are still unknown. A prominent feature in the EEG of some patients is the emergence of a strong power peak in the β–frequency band, which moves to the α–frequency band while increasing the anesthetic concentration. This feature is called the beta-buzz. In the present study, we use a thalamo-cortical neural population feedback model to reproduce observed characteristic features in frontal EEG power obtained experimentally during propofol general anesthesia, such as this beta-buzz. First, we find that the spectral power peak in the α– and δ–frequency ranges depend on the decay rate constant of excitatory and inhibitory synapses, but the anesthetic action on synapses does not explain the beta-buzz. Moreover, considering the action of propofol on the transmission delay between cortex and thalamus, the model reveals that the beta-buzz may result from a prolongation of the transmission delay by increasing propofol concentration. A corresponding relationship between transmission delay and anesthetic blood concentration is derived. Finally, an analytical stability study demonstrates that increasing propofol concentration moves the systems resting state towards its stability threshold

Mitochondrial Dysfunction and Apoptosis in Cumulus Cells of Type I Diabetic Mice

Impaired oocyte quality has been demonstrated in diabetic mice; however, the potential pathways by which maternal diabetes exerts its effects on the oocyte are poorly understood. Cumulus cells are in direct contact with the oocyte via gap junctions and provide essential nutrients to support oocyte development. In this study, we investigated the effects of maternal diabetes on the mitochondrial status in cumulus cells. We found an increased frequency of fragmented mitochondria, a decreased transmembrane potential and an aggregated distribution of mitochondria in cumulus cells from diabetic mice. Furthermore, while mitochondrial biogenesis in cumulus cells was induced by maternal diabetes, their metabolic function was disrupted as evidenced by lower ATP and citrate levels. Moreover, we present evidence suggesting that the mitochondrial impairments induced by maternal diabetes, at least in part, lead to cumulus cell apoptosis through the release of cytochrome c. Together the deleterious effects on cumulus cells may disrupt trophic and signaling interactions with the oocyte, contributing to oocyte incompetence and thus poor pregnancy outcomes in diabetic females

Medicinal and ethnoveterinary remedies of hunters in Trinidad

BACKGROUND: Ethnomedicines are used by hunters for themselves and their hunting dogs in Trinidad. Plants are used for snakebites, scorpion stings, for injuries and mange of dogs and to facilitate hunting success. RESULTS: Plants used include Piper hispidum, Pithecelobium unguis-cati, Bauhinia excisa, Bauhinia cumanensis, Cecropia peltata, Aframomum melegueta, Aristolochia rugosa, Aristolochia trilobata, Jatropha curcas, Jatropha gossypifolia, Nicotiana tabacum, Vernonia scorpioides, Petiveria alliacea, Renealmia alpinia, Justicia secunda, Phyllanthus urinaria,Phyllanthus niruri,Momordica charantia, Xiphidium caeruleum, Ottonia ovata, Lepianthes peltata, Capsicum frutescens, Costus scaber, Dendropanax arboreus, Siparuma guianensis, Syngonium podophyllum, Monstera dubia, Solanum species, Eclipta prostrata, Spiranthes acaulis, Croton gossypifolius, Barleria lupulina, Cola nitida, Acrocomia ierensis (tentative ID). CONCLUSION: Plant use is based on odour, and plant morphological characteristics and is embedded in a complex cultural context based on indigenous Amerindian beliefs. It is suggested that the medicinal plants exerted a physiological action on the hunter or his dog. Some of the plants mentioned contain chemicals that may explain the ethnomedicinal and ethnoveterinary use. For instance some of the plants influence the immune system or are effective against internal and external parasites. Plant baths may contribute to the health and well being of the hunting dogs

25th Annual Computational Neuroscience Meeting: CNS-2016

Abstracts of the 25th Annual Computational Neuroscience Meeting: CNS-2016 Seogwipo City, Jeju-do, South Korea. 2–7 July 201

Catalogues of voids as antihaloes in the local Universe

A recently proposed algorithm identifies voids in simulations as the regions associated with haloes when the initial overdensity field is negated. We apply this method to the real Universe by running a suite of constrained simulations of the 2M++ volume with initial conditions inferred by the BORG algorithm, along with the corresponding inverted set. Our 101 inverted and uninverted simulations, spanning the BORG posterior, each identify ∼150 000 ‘voids as antihaloes’ with mass exceeding 4.38 × 1011 M⊙ (100 particles) at z = 0 in a full-sky sphere of radius 155 Mpc h−1 around the Milky Way. We calculate the size function, volume filling fraction, ellipticity, central density, specific angular momentum, clustering, and stacked density profile of the voids, and cross-correlate them with those produced by VIDE on the same simulations. We make our antihalo and VIDE catalogues publicly available

The effect of local universe constraints on halo abundance and clustering

Cosmological N-body simulations of the dark matter component of the universe typically use initial conditions with a fixed power spectrum and random phases of the density field, leading to structure consistent with the local distribution of galaxies only in a statistical sense. It is, however, possible to infer the initial phases which lead to the configuration of galaxies and clusters that we see around us. We analyse the CSiBORG suite of 101 simulations, formed by constraining the density field within 155 Mpc/h with dark matter particle mass 4.38×109M⊙, to quantify the degree to which constraints imposed on 2.65 Mpc/h scales reduce variance in the halo mass function and halo-halo cross-correlation function on a range of scales. This is achieved by contrasting CSiBORG with a subset of the unconstrained Quijote simulations and expectations for the ΛCDM average. Using the FOF, PHEW and HOP halofinders, we show that the CSiBORG suite beats cosmic variance at large mass scales (≳1014M⊙/h), which are most strongly constrained by the initial conditions, and exhibits a significant halo-halo cross-correlation out to ∼30 Mpc/h. Moreover, the effect of the constraints percolates down to lower mass objects and to scales below those on which they are imposed. Finally, we develop an algorithm to "twin" halos between realisations and show that approximately 50% of halos with mass greater than 1015M⊙/h can be identified in all realisations of the CSiBORG suite. We make the CSiBORG halo catalogues publicly available for future applications requiring knowledge of the local halo field