35 research outputs found
Disseminated primary cutaneous histoplasmosis successfully treated with itraconazole
A 60-year-old immunocompetent lady with disseminated primary cutaneous
histoplasmosis is reported. Histology showed a granulomatous skin
infiltrate with numerous intracellular PAS positive rounded yeast cells
within macrophages. Culture on Sabouraud's dextrose agar yielded a
typical cottony white colony characteristic of Histoplasma capsulatum
. Treatment with itraconazole showed an excellent response
Study - Dexamethasone-cyclophosphamide pulse therapy in systemic lupus erythematosus
BACKGROUND AND AIMS: Therapy systemic lupus erythematosus (SLE) has
been generally discouraging. Methyl-prednisolone pulse therapy has been
used for various connective tissue disorders. We used intravenous
dexamethasone cyclophosphamide pulse therapy to treat SLE. METHODS:
Fourteen patients (10 females and 4 males) between the age of 15-48
years with definite or classical clinical criteria laid by American
Rheumatism Association criteria were treated by
Dexamethasone-Cyclophosphamide pulse (DCP) therapy at our center.
RESULTS: It was possible to induce a complete clinical remission with
DCP therapy in most of the patients thereby offering them life free
from disease and drugs. The side effects commonly observed with
conventional daily dose regimen of corticosteroids were not present or
were mild. CONCLUSIONS: Almost all patients had good response after
3-4 pulses to allow them a normal life style. Fever, malar rash and
oral ulceration responded early but photosensitivity, discoid rash,
alopecia and joint pains took some more time