Rural indebtedness : concept, correlates and consequences: a study of four tribal villages in the North Lakhimpur subdivision, Assam

Indebtedness has been acknowledged as one of the most infamous stumbling blocks in the way of rural prosperity. It is cancerous, self-perpetuating, malignant and maleficent. It abates agricultural production, abashes social psyche, aggravates inequalities in the distribution of socioeconomic opportunities and benefits, arrests social progress and misdirects social efforts. In the Indian rural context, indebtedness characterizes: (i). unproductive usage of loan, (ii). usurious ensnaring of the borrower, (iii). captivation of productive resources, (iv). exercise of coercive and exploitative economic and social powers by the lender, (v). compulsion, plight, misery and feeling of guilt and helplessness, and (vi). erosion of social status of the borrower. In this study we propose an empirical study to measure indebtedness, identify its correlates and to assess the consequences of indebtedness on the productive and distributive performance on the rural economy. We have collected primary data from four tribal villages. The selection of these villages has been made purposively. We hold the opinion that the tribal population in the rural areas of Assam has been least exposed to the credit programmes launched by the public agencies and hence a study of indebtedness provides us with a deeper insight in the problem. We have observed that in the Indian context rural indebtedness is resonant with the overtones of unproductive usage, usurious ensnaring and deplorable condition of the poor farmers and agricultural labourers. We have surveyed four tribal villages and based on the data thus collected identified some measures of indebtedness that can help us operationally in analyzing the incidence, process and impacts of rural indebtedness. These measures are per capita loan and per capita loan per agricultural asset held by the households and these measures are good representatives of the degree of indebtedness. We have analyzed the productive and distributive effects of indebtedness and found that it leads to decline in agricultural productivity, captivation of productive resources and aggravation of inequalities in the rural community. Further, our finding is that indebtedness is initiated by unproductive expenditure. This in turn captivates agricultural assets, abates productivity and reduces the repaying capacity of the borrower. Our study may suggest that in order to ameliorate the conditions of the indebted rural mass we have to motivate them to minimize conspicuous consumption, especially if the households cannot afford it without borrowing. Educational planning may help us to attain this goal of making the rural mass aware of the merits of prudence and the demerits of conspicuous consumption. Further, to stop the captivation of productive assets, institutional loan should be provided on easy terms. This objective may be attained by making the cooperative and bank loans easily available.Rural indebtedness; correlates; consequences; measures of incidence; distributive effects; causal chain; Assam; primary data; tribal villages; poverty

Divergent barotropic instability of the tropical asymmetric easterly jet

The divergent barotropic instability of a zonally averaged, observed, tropical, upper tropospheric, monsoon easterly jet is investigated by numerical integration of a linear spectral model. The Rossby radius of deformation for the upper troposphere is computed from a three-layer model of the atmosphere. It is shown that the antisymmetric zonal flow components in the jet contribute in stabilizing the short waves and destabilizing the long waves. Furthermore, the maximum amplitude of the asymmetric preferred wave is shifted southward (to 6°N) to a region where a largest positive maximum of −ūvv is located for the asymmetric profile. A large decrease in the meridional scale of the wave and a threefold increase in the ratio of the computed maximum southward-to-northward easterly momentum transports is also found for the asymmetric jet compared to the symmetric jet. The divergence is found to increase the growth rates of all the waves and, also to increase the preferred wavelength. The most unstable divergent asymmetric wave is shown to have a wavelength of 6500 km, an e-folding time of 6.5 days and a westward phase speed of 23.5 m s−1. The zonal scale of the preferred wave is nearly equal to the Rossby radius of deformation

Efficiency of liquid culture systems over conventional micropropagation: A progress towards commercialization

The most common methods of micropropagation involve the proliferation of shoots via a semi solid system. While such semi solid systems have been moderately to highly successful in terms ofmultiplication yields, it has become increasingly important to improve productivity and reduce the time taken to multiply commercially important material. Micropropagation by conventional techniques istypically a labor intensive time taking means of clonal propagation. To overcome this, the use of shake cultures utilizing liquid culture medium has been promoted. The liquid medium allows the close contactwith the tissue which stimulates and facilitates the uptake of nutrients and phytohormones, leading to better shoot and root growth. Continuous shaking promotes lesser expression of apical dominance which generally leads to induction and proliferation of numerous axillary buds. Further, with in the shake culture conditions, the growth and multiplication rate of shoots is enhanced by forced aeration,since continuous shaking of medium provides ample oxygen supply to the tissue which ultimately leads to their faster growth. Bioreactor provides a rapid and efficient clonal propagation systemutilizing liquid medium to avoid intensive manual handling. Automation of micropropagation in bioreactors has been advanced by several authors as a possible way of reducing cost of micropropagation. Micropropagation in bioreactors for optimal plant production depends upon better understanding of physiological and biochemical responses of plant to the signals of culture microenvironment and an optimization of specific physical and chemical culture conditions to controlthe morphogenesis of plants in liquid culture systems

A simple method of DNA extraction from coffee seeds suitable for PCR analysis

High quality genomic DNA was successfully extracted from coffee seeds using a simple protocol devoid of liquid nitrogen or freeze-drying and proteinase K. The isolated DNA was quantified using spectrophotometer and using agarose gel electrophoresis. The DNA was free from polysaccharides, polyphenols, RNA and other contaminants. The quantity of DNA ranged from 180 to 630 g/g of seed powder. Quality of DNA was confirmed by digestion using EcoRI, HindIII and PstI restrictionendonucleases and complete digestion was observed. PCR with random decamer primers and consensus primers of mitochondria and chloroplast DNA and PCR-RFLP revealed the suitability of the DNA for PCR based marker techniques including diagnostics

Rural indebtedness : concept, correlates and consequences: a study of four tribal villages in the North Lakhimpur subdivision, Assam

Indebtedness has been acknowledged as one of the most infamous stumbling blocks in the way of rural prosperity. It is cancerous, self-perpetuating, malignant and maleficent. It abates agricultural production, abashes social psyche, aggravates inequalities in the distribution of socioeconomic opportunities and benefits, arrests social progress and misdirects social efforts. In the Indian rural context, indebtedness characterizes: (i). unproductive usage of loan, (ii). usurious ensnaring of the borrower, (iii). captivation of productive resources, (iv). exercise of coercive and exploitative economic and social powers by the lender, (v). compulsion, plight, misery and feeling of guilt and helplessness, and (vi). erosion of social status of the borrower. In this study we propose an empirical study to measure indebtedness, identify its correlates and to assess the consequences of indebtedness on the productive and distributive performance on the rural economy. We have collected primary data from four tribal villages. The selection of these villages has been made purposively. We hold the opinion that the tribal population in the rural areas of Assam has been least exposed to the credit programmes launched by the public agencies and hence a study of indebtedness provides us with a deeper insight in the problem. We have observed that in the Indian context rural indebtedness is resonant with the overtones of unproductive usage, usurious ensnaring and deplorable condition of the poor farmers and agricultural labourers. We have surveyed four tribal villages and based on the data thus collected identified some measures of indebtedness that can help us operationally in analyzing the incidence, process and impacts of rural indebtedness. These measures are per capita loan and per capita loan per agricultural asset held by the households and these measures are good representatives of the degree of indebtedness. We have analyzed the productive and distributive effects of indebtedness and found that it leads to decline in agricultural productivity, captivation of productive resources and aggravation of inequalities in the rural community. Further, our finding is that indebtedness is initiated by unproductive expenditure. This in turn captivates agricultural assets, abates productivity and reduces the repaying capacity of the borrower. Our study may suggest that in order to ameliorate the conditions of the indebted rural mass we have to motivate them to minimize conspicuous consumption, especially if the households cannot afford it without borrowing. Educational planning may help us to attain this goal of making the rural mass aware of the merits of prudence and the demerits of conspicuous consumption. Further, to stop the captivation of productive assets, institutional loan should be provided on easy terms. This objective may be attained by making the cooperative and bank loans easily available

Rural indebtedness : concept, correlates and consequences: a study of four tribal villages in the North Lakhimpur subdivision, Assam

Indebtedness has been acknowledged as one of the most infamous stumbling blocks in the way of rural prosperity. It is cancerous, self-perpetuating, malignant and maleficent. It abates agricultural production, abashes social psyche, aggravates inequalities in the distribution of socioeconomic opportunities and benefits, arrests social progress and misdirects social efforts. In the Indian rural context, indebtedness characterizes: (i). unproductive usage of loan, (ii). usurious ensnaring of the borrower, (iii). captivation of productive resources, (iv). exercise of coercive and exploitative economic and social powers by the lender, (v). compulsion, plight, misery and feeling of guilt and helplessness, and (vi). erosion of social status of the borrower. In this study we propose an empirical study to measure indebtedness, identify its correlates and to assess the consequences of indebtedness on the productive and distributive performance on the rural economy. We have collected primary data from four tribal villages. The selection of these villages has been made purposively. We hold the opinion that the tribal population in the rural areas of Assam has been least exposed to the credit programmes launched by the public agencies and hence a study of indebtedness provides us with a deeper insight in the problem. We have observed that in the Indian context rural indebtedness is resonant with the overtones of unproductive usage, usurious ensnaring and deplorable condition of the poor farmers and agricultural labourers. We have surveyed four tribal villages and based on the data thus collected identified some measures of indebtedness that can help us operationally in analyzing the incidence, process and impacts of rural indebtedness. These measures are per capita loan and per capita loan per agricultural asset held by the households and these measures are good representatives of the degree of indebtedness. We have analyzed the productive and distributive effects of indebtedness and found that it leads to decline in agricultural productivity, captivation of productive resources and aggravation of inequalities in the rural community. Further, our finding is that indebtedness is initiated by unproductive expenditure. This in turn captivates agricultural assets, abates productivity and reduces the repaying capacity of the borrower. Our study may suggest that in order to ameliorate the conditions of the indebted rural mass we have to motivate them to minimize conspicuous consumption, especially if the households cannot afford it without borrowing. Educational planning may help us to attain this goal of making the rural mass aware of the merits of prudence and the demerits of conspicuous consumption. Further, to stop the captivation of productive assets, institutional loan should be provided on easy terms. This objective may be attained by making the cooperative and bank loans easily available

RIG-I Mediates Innate Immune Response in Mouse Neurons Following Japanese Encephalitis Virus Infection

Neuroinflammation associated with Japanese encephalitis (JE) is mainly due to the activation of glial cells with subsequent release of proinflammatory mediators from them. The recognition of viral RNA, in part, by the pattern recognition receptor retinoic acid-inducible gene I (RIG-I) has been indicated to have a role in such processes. Even though neurons are also known to express this receptor, its role after JE virus (JEV) infections is yet to be elucidated.Upon infecting murine neuroblastoma cells and primary cortical neurons with JEV the expression profile of key proinflammatory cyto/chemokines were analyzed by qRT-PCR and bead array, both before and after ablation of RIG-I. Immunoblotting was performed to evaluate the levels of key molecules downstream to RIG-I leading to production of proinflammatory mediators. Changes in the intracellular viral antigen expression were confirmed by intracellular staining and immunoblotting. JEV infection induced neuronal expression of IL-6, IL-12p70, MCP-1, IP-10 and TNF-α in a time-dependent manner, which showed significant reduction upon RIG-I ablation. Molecules downstream to RIG-I showed significant changes upon JEV-infection, that were modulated following RIG-I ablation. Ablation of RIG-I in neurons also increased their susceptibility to JEV.In this study we propose that neurons are one of the potential sources of proinflammatory cyto/chemokines in JEV-infected brain that are produced via RIG-I dependent pathways. Ablation of RIG-I in neurons leads to increased viral load and reduced release of the cyto/chemokines

Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials

In recent decades, interest in the Cordyceps genus has amplified due to its immunostimulatory potential. Cordyceps species, its extracts, and bioactive constituents have been related with cytokine production such as interleukin (IL)-1ß, IL-2, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor (TNF)-a, phagocytosis stimulation of immune cells, nitric oxide production by increasing inducible nitric oxide synthase activity, and stimulation of inflammatory response via mitogen-activated protein kinase pathway. Other pharmacological activities like antioxidant, anti-cancer, antihyperlipidemic, anti-diabetic, anti-fatigue, anti-aging, hypocholesterolemic, hypotensive, vasorelaxation, anti-depressant, aphrodisiac, and kidney protection, has been reported in pre-clinical studies. These biological activities are correlated with the bioactive compounds present in Cordyceps including nucleosides, sterols, flavonoids, cyclic peptides, phenolic, bioxanthracenes, polyketides, and alkaloids, being the cyclic peptides compounds the most studied. An organized review of the existing literature was executed by surveying several databanks like PubMed, Scopus, etc. using keywords like Cordyceps, cordycepin, immune system, immunostimulation, immunomodulatory, pharmacology, anti-cancer, anti-viral, clinical trials, ethnomedicine, pharmacology, phytochemical analysis, and different species names. This review collects and analyzes state-of-the-art about the properties of Cordyceps species along with ethnopharmacological properties, application in food, chemical compounds, extraction of bioactive compounds, and various pharmacological properties with a special focus on the stimulatory properties of immunity.This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1G1A1004667), Republic of Korea

Practical computational toolkits for dendrimers and dendrons structure design

Dendrimers and dendrons offer an excellent platform for developing novel drug delivery systems and medicines. The rational design and further development of these repetitively branched systems are restricted by difficulties in scalable synthesis and structural determination, which can be overcome by judicious use of molecular modelling and molecular simulations. A major difficulty to utilise in silico studies to design dendrimers lies in the laborious generation of their structures. Current modelling tools utilise automated assembly of simpler dendrimers or the inefficient manual assembly of monomer precursors to generate more complicated dendrimer structures. Herein we describe two novel graphical user interface (GUI) toolkits written in Python that provide an improved degree of automation for rapid assembly of dendrimers and generation of their 2D and 3D structures. Our first toolkit uses the RDkit library, SMILES nomenclature of monomers and SMARTS reaction nomenclature to generate SMILES and mol files of dendrimers without 3D coordinates. These files are used for simple graphical representations and storing their structures in databases. The second toolkit assembles complex topology dendrimers from monomers to construct 3D dendrimer structures to be used as starting points for simulation using existing and widely available software and force fields. Both tools were validated for ease-of-use to prototype dendrimer structure and the second toolkit was especially relevant for dendrimers of high complexity and size.Peer reviewe