99 research outputs found
Deep Karaoke: Extracting Vocals from Musical Mixtures Using a Convolutional Deep Neural Network
Identification and extraction of singing voice from within musical mixtures
is a key challenge in source separation and machine audition. Recently, deep
neural networks (DNN) have been used to estimate 'ideal' binary masks for
carefully controlled cocktail party speech separation problems. However, it is
not yet known whether these methods are capable of generalizing to the
discrimination of voice and non-voice in the context of musical mixtures. Here,
we trained a convolutional DNN (of around a billion parameters) to provide
probabilistic estimates of the ideal binary mask for separation of vocal sounds
from real-world musical mixtures. We contrast our DNN results with more
traditional linear methods. Our approach may be useful for automatic removal of
vocal sounds from musical mixtures for 'karaoke' type applications
Predicting language diversity with complex network
Evolution and propagation of the world's languages is a complex phenomenon,
driven, to a large extent, by social interactions. Multilingual society can be
seen as a system of interacting agents, where the interaction leads to a
modification of the language spoken by the individuals. Two people can reach
the state of full linguistic compatibility due to the positive interactions,
like transfer of loanwords. But, on the other hand, if they speak entirely
different languages, they will separate from each other. These simple
observations make the network science the most suitable framework to describe
and analyze dynamics of language change. Although many mechanisms have been
explained, we lack a qualitative description of the scaling behavior for
different sizes of a population. Here we address the issue of the language
diversity in societies of different sizes, and we show that local interactions
are crucial to capture characteristics of the empirical data. We propose a
model of social interactions, extending the idea from, that explains the growth
of the language diversity with the size of a population of country or society.
We argue that high clustering and network disintegration are the most important
characteristics of models properly describing empirical data. Furthermore, we
cancel the contradiction between previous models and the Solomon Islands case.
Our results demonstrate the importance of the topology of the network, and the
rewiring mechanism in the process of language change
A Sex-Specific Metabolite Identified in a Marine Invertebrate Utilizing Phosphorus-31 Nuclear Magnetic Resonance
Hormone level differences are generally accepted as the primary cause for sexual dimorphism in animal and human development. Levels of low molecular weight metabolites also differ between men and women in circulating amino acids, lipids and carbohydrates and within brain tissue. While investigating the metabolism of blue crab tissues using Phosphorus-31 Nuclear Magnetic Resonance, we discovered that only the male blue crab (Callinectes sapidus) contained a phosphorus compound with a chemical shift well separated from the expected phosphate compounds. Spectra obtained from male gills were readily differentiated from female gill spectra. Analysis from six years of data from male and female crabs documented that the sex-specificity of this metabolite was normal for this species. Microscopic analysis of male and female gills found no differences in their gill anatomy or the presence of parasites or bacteria that might produce this phosphorus compound. Analysis of a rare gynandromorph blue crab (laterally, half male and half female) proved that this sex-specificity was an intrinsic biochemical process and was not caused by any variations in the diet or habitat of male versus female crabs. The existence of a sex-specific metabolite is a previously unrecognized, but potentially significant biochemical phenomenon. An entire enzyme system has been synthesized and activated only in one sex. Unless blue crabs are a unique species, sex-specific metabolites are likely to be present in other animals. Would the presence or absence of a sex-specific metabolite affect an animal's development, anatomy and biochemistry
Host-Species Transferrin Receptor 1 Orthologs Are Cellular Receptors for Nonpathogenic New World Clade B Arenaviruses
The ability of a New World (NW) clade B arenavirus to enter cells using human transferrin receptor 1 (TfR1) strictly correlates with its ability to cause hemorrhagic fever. Amapari (AMAV) and Tacaribe (TCRV), two nonpathogenic NW clade B arenaviruses that do not use human TfR1, are closely related to the NW arenaviruses that cause hemorrhagic fevers. Here we show that pseudotyped viruses bearing the surface glycoprotein (GP) of AMAV or TCRV can infect cells using the TfR1 orthologs of several mammalian species, including those of their respective natural hosts, the small rodent Neacomys spinosus and the fruit bat Artibeus jamaicensis. Mutation of one residue in human TfR1 makes it a functional receptor for TCRV, and mutation of four residues makes it a functional receptor for AMAV. Our data support an in vivo role for TfR1 in the replication of most, if not all, NW clade B arenaviruses, and suggest that with modest changes in their GPs the nonpathogenic arenaviruses could use human TfR1 and emerge as human pathogens
HemaMax™, a Recombinant Human Interleukin-12, Is a Potent Mitigator of Acute Radiation Injury in Mice and Non-Human Primates
HemaMax, a recombinant human interleukin-12 (IL-12), is under development to address an unmet medical need for effective treatments against acute radiation syndrome due to radiological terrorism or accident when administered at least 24 hours after radiation exposure. This study investigated pharmacokinetics, pharmacodynamics, and efficacy of m-HemaMax (recombinant murine IL-12), and HemaMax to increase survival after total body irradiation (TBI) in mice and rhesus monkeys, respectively, with no supportive care. In mice, m-HemaMax at an optimal 20 ng/mouse dose significantly increased percent survival and survival time when administered 24 hours after TBI between 8–9 Gy (p<0.05 Pearson's chi-square test). This survival benefit was accompanied by increases in plasma interferon-γ (IFN-γ) and erythropoietin levels, recovery of femoral bone hematopoiesis characterized with the presence of IL-12 receptor β2 subunit–expressing myeloid progenitors, megakaryocytes, and osteoblasts. Mitigation of jejunal radiation damage was also examined. At allometrically equivalent doses, HemaMax showed similar pharmacokinetics in rhesus monkeys compared to m-HemaMax in mice, but more robustly increased plasma IFN-γ levels. HemaMax also increased plasma erythropoietin, IL-15, IL-18, and neopterin levels. At non-human primate doses pharmacologically equivalent to murine doses, HemaMax (100 ng/Kg and 250 ng/Kg) administered at 24 hours after TBI (6.7 Gy/LD50/30) significantly increased percent survival of HemaMax groups compared to vehicle (p<0.05 Pearson's chi-square test). This survival benefit was accompanied by a significantly higher leukocyte (neutrophils and lymphocytes), thrombocyte, and reticulocyte counts during nadir (days 12–14) and significantly less weight loss at day 12 compared to vehicle. These findings indicate successful interspecies dose conversion and provide proof of concept that HemaMax increases survival in irradiated rhesus monkeys by promoting hematopoiesis and recovery of immune functions and possibly gastrointestinal functions, likely through a network of interactions involving dendritic cells, osteoblasts, and soluble factors such as IL-12, IFN-γ, and cytoprotectant erythropoietin
Low-mass and sub-stellar eclipsing binaries in stellar clusters
We highlight the importance of eclipsing double-line binaries in our
understanding on star formation and evolution. We review the recent discoveries
of low-mass and sub-stellar eclipsing binaries belonging to star-forming
regions, open clusters, and globular clusters identified by ground-based
surveys and space missions with high-resolution spectroscopic follow-up. These
discoveries provide benchmark systems with known distances, metallicities, and
ages to calibrate masses and radii predicted by state-of-the-art evolutionary
models to a few percent. We report their density and discuss current
limitations on the accuracy of the physical parameters. We discuss future
opportunities and highlight future guidelines to fill gaps in age and
metallicity to improve further our knowledge of low-mass stars and brown
dwarfs.Comment: 30 pages, 5 figures, no table. Review pape
Can environmental or occupational hazards alter the sex ratio at birth? A systematic review
More than 100 studies have examined whether environmental or occupational exposures of parents affect the sex ratio of their offspring at birth. For this review, we searched Medline and Web of Science using the terms ‘sex ratio at birth’ and ‘sex ratio and exposure’ for all dates, and reviewed bibliographies of relevant studies to find additional articles. This review focuses on exposures that have been the subject of at least four studies including polychlorinated biphenyls (PCBs), dioxins, pesticides, lead and other metals, radiation, boron, and g-forces. For paternal exposures, only dioxins and PCBs were consistently associated with sex ratios higher or lower than the expected 1.06. Dioxins were associated with a decreased proportion of male births, whereas PCBs were associated with an increased proportion of male births. There was limited evidence for a decrease in the proportion of male births after paternal exposure to DBCP, lead, methylmercury, non-ionizing radiation, ionizing radiation treatment for childhood cancer, boron, or g-forces. Few studies have found higher or lower sex ratios associated with maternal exposures. Studies in humans and animals have found a reduction in the number of male births associated with lower male fertility, but the mechanism by which environmental hazards might change the sex ratio has not yet been established
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