8 research outputs found
The association of body size in early to mid-life with adult urinary 6-sulfatoxymelatonin levels among night shift health care workers
Modulation of vascular reactivity by perivascular adipose tissue (PVAT)
Purpose of Review: In this review we discuss the role of perivascular adipose tissue (PVAT) in the modulation of vascular contractility and arterial pressure, focusing on the role of the renin-angiotensin-aldosterone system and oxidative stress/inflammation.
Recent Findings: PVAT possesses an relevant endocrine-paracrine activity, which may be altered in several pathophysiological and clinical conditions. During the last two decades it has been shown PVAT may modulate vascular reactivity. It has also been previously demonstrated that inflammation in adipose tissue may be implicated in vascular dysfunction. In particular, adipocytes secrete a number of adipokines with various functions, as well as several vasoactive factors, together with components of the renin-angiotensin system which may act at local or at systemic level. It has been shown that the anticontractile effect of PVAT is lost in obesity, probably as a consequence of the development of adipocyte hypertrophy, inflammation, and oxidative stress.
Summary: Adipose tissue dysfunction is interrelated with inflammation and oxidative stress, thus contributing to endothelial dysfunction observed in several pathological and clinical conditions such as obesity and hypertension. Decreased local adiponectin level, macrophage recruitment and infiltration, and activation of renin-angiotensin-aldosterone system could play an important role in this regards
Interârelationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity
Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes
Hepatic Macrosteatosis Is Partially Converted to Microsteatosis by Melatonin Supplementation in ob/ob Mice Non-Alcoholic Fatty Liver Disease
Cytoprotection by Melatonin: The Metabolic Syndrome as an Example
Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, in part because of its function as a metabolic regulator and mitochondrial protector. As a chronobiotic/cytoprotective agent, melatonin may occupy a special place in the prevention and treatment of metabolic syndrome.Fil: Cardinali, Daniel Pedro. Pontificia Universidad CatĂłlica Argentina "Santa MarĂa de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Vigo, Daniel Eduardo. Pontificia Universidad CatĂłlica Argentina "Santa MarĂa de los Buenos Aires". Instituto de Investigaciones BiomĂ©dicas. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones BiomĂ©dicas; Argentin