3,393 research outputs found
A habituation account of change detection in same/different judgments
We investigated the basis of change detection in a short-term priming task. In two experiments, participants were asked to indicate whether or not a target word was the same as a previously presented cue. Data from an experiment measuring magnetoencephalography failed to find different patterns for “same” and “different” responses, consistent with the claim that both arise from a common neural source, with response magnitude defining the difference between immediate novelty versus familiarity. In a behavioral experiment, we tested and confirmed the predictions of a habituation account of these judgments by comparing conditions in which the target, the cue, or neither was primed by its presentation in the previous trial. As predicted, cue-primed trials had faster response times, and target-primed trials had slower response times relative to the neither-primed baseline. These results were obtained irrespective of response repetition and stimulus–response contingencies. The behavioral and brain activity data support the view that detection of change drives performance in these tasks and that the underlying mechanism is neuronal habituation
Recognizing Treelike k-Dissimilarities
A k-dissimilarity D on a finite set X, |X| >= k, is a map from the set of
size k subsets of X to the real numbers. Such maps naturally arise from
edge-weighted trees T with leaf-set X: Given a subset Y of X of size k, D(Y) is
defined to be the total length of the smallest subtree of T with leaf-set Y .
In case k = 2, it is well-known that 2-dissimilarities arising in this way can
be characterized by the so-called "4-point condition". However, in case k > 2
Pachter and Speyer recently posed the following question: Given an arbitrary
k-dissimilarity, how do we test whether this map comes from a tree? In this
paper, we provide an answer to this question, showing that for k >= 3 a
k-dissimilarity on a set X arises from a tree if and only if its restriction to
every 2k-element subset of X arises from some tree, and that 2k is the least
possible subset size to ensure that this is the case. As a corollary, we show
that there exists a polynomial-time algorithm to determine when a
k-dissimilarity arises from a tree. We also give a 6-point condition for
determining when a 3-dissimilarity arises from a tree, that is similar to the
aforementioned 4-point condition.Comment: 18 pages, 4 figure
An inhibitory pull-push circuit in frontal cortex.
Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input
Partially Supersymmetric Composite Higgs Models
We study the idea of the Higgs as a pseudo-Goldstone boson within the
framework of partial supersymmetry in Randall-Sundrum scenarios and their CFT
duals. The Higgs and third generation of the MSSM are composites arising from a
strongly coupled supersymmetric CFT with global symmetry SO(5) spontaneously
broken to SO(4), whilst the light generations and gauge fields are elementary
degrees of freedom whose couplings to the strong sector explicitly break the
global symmetry as well as supersymmetry. The presence of supersymmetry in the
strong sector may allow the compositeness scale to be raised to ~10 TeV without
fine tuning, consistent with the bounds from precision electro-weak
measurements and flavour physics. The supersymmetric flavour problem is also
solved. At low energies, this scenario reduces to the "More Minimal
Supersymmetric Standard Model" where only stops, Higgsinos and gauginos are
light and within reach of the LHC.Comment: 28 pages. v2 minor changes and Refs. adde
Gene expression drives the evolution of dominance.
Dominance is a fundamental concept in molecular genetics and has implications for understanding patterns of genetic variation, evolution, and complex traits. However, despite its importance, the degree of dominance in natural populations is poorly quantified. Here, we leverage multiple mating systems in natural populations of Arabidopsis to co-estimate the distribution of fitness effects and dominance coefficients of new amino acid changing mutations. We find that more deleterious mutations are more likely to be recessive than less deleterious mutations. Further, this pattern holds across gene categories, but varies with the connectivity and expression patterns of genes. Our work argues that dominance arises as a consequence of the functional importance of genes and their optimal expression levels
Endothelio-hematopoietic relationship: getting closer to the beginnings
The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor - the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in vitro differentiation studies. Teixeira and colleagues describe a novel enhancer that drives specific eGFP expression in blood islands of the electroporated chick embryo, thereby presenting a tool potentially suitable for analysis of hemangioblast differentiation and development of blood islands
SUSY Splits, But Then Returns
We study the phenomenon of accidental or "emergent" supersymmetry within
gauge theory and connect it to the scenarios of Split Supersymmetry and Higgs
compositeness. Combining these elements leads to a significant refinement and
extension of the proposal of Partial Supersymmetry, in which supersymmetry is
broken at very high energies but with a remnant surviving to the weak scale.
The Hierarchy Problem is then solved by a non-trivial partnership between
supersymmetry and compositeness, giving a promising approach for reconciling
Higgs naturalness with the wealth of precision experimental data. We discuss
aspects of this scenario from the AdS/CFT dual viewpoint of higher-dimensional
warped compactification. It is argued that string theory constructions with
high scale supersymmetry breaking which realize warped/composite solutions to
the Hierarchy Problem may well be accompanied by some or all of the features
described. The central phenomenological considerations and expectations are
discussed, with more detailed modelling within warped effective field theory
reserved for future work.Comment: 29 pages. Flavor and CP constraints on left-right symmetric structure
briefly discussed. References adde
Export of functional Streptomyces coelicolor alditol oxidase to the periplasm or cell surface of Escherichia coli and its application in whole-cell biocatalysis
Streptomyces coelicolor A3(2) alditol oxidase (AldO) is a soluble monomeric flavoprotein in which the flavin cofactor is covalently linked to the polypeptide chain. AldO displays high reactivity towards different polyols such as xylitol and sorbitol. These characteristics make AldO industrially relevant, but full biotechnological exploitation of this enzyme is at present restricted by laborious and costly purification steps. To eliminate the need for enzyme purification, this study describes a whole-cell AldO biocatalyst system. To this end, we have directed AldO to the periplasm or cell surface of Escherichia coli. For periplasmic export, AldO was fused to endogenous E. coli signal sequences known to direct their passenger proteins into the SecB, signal recognition particle (SRP), or Twin-arginine translocation (Tat) pathway. In addition, AldO was fused to an ice nucleation protein (INP)-based anchoring motif for surface display. The results show that Tat-exported AldO and INP-surface-displayed AldO are active. The Tat-based system was successfully employed in converting xylitol by whole cells, whereas the use of the INP-based system was most likely restricted by lipopolysaccharide LPS in wild-type cells. It is anticipated that these whole-cell systems will be a valuable tool for further biological and industrial exploitation of AldO and other cofactor-containing enzymes.
Cross-talk between cd1d-restricted nkt cells and γδ cells in t regulatory cell response
CD1d is a non-classical major histocompatibility class 1-like molecule which primarily presents either microbial or endogenous glycolipid antigens to T cells involved in innate immunity. Natural killer T (NKT) cells and a subpopulation of γδ T cells expressing the Vγ4 T cell receptor (TCR) recognize CD1d. NKT and Vγ4 T cells function in the innate immune response via rapid activation subsequent to infection and secrete large quantities of cytokines that both help control infection and modulate the developing adaptive immune response. T regulatory cells represent one cell population impacted by both NKT and Vγ4 T cells. This review discusses the evidence that NKT cells promote T regulatory cell activation both through direct interaction of NKT cell and dendritic cells and through NKT cell secretion of large amounts of TGFβ, IL-10 and IL-2. Recent studies have shown that CD1d-restricted Vγ4 T cells, in contrast to NKT cells, selectively kill T regulatory cells through a caspase-dependent mechanism. Vγ4 T cell elimination of the T regulatory cell population allows activation of autoimmune CD8+ effector cells leading to severe cardiac injury in a coxsackievirus B3 (CVB3) myocarditis model in mice. CD1d-restricted immunity can therefore lead to either immunosuppression or autoimmunity depending upon the type of innate effector dominating during the infection
Magnetism, FeS colloids, and Origins of Life
A number of features of living systems: reversible interactions and weak
bonds underlying motor-dynamics; gel-sol transitions; cellular connected
fractal organization; asymmetry in interactions and organization; quantum
coherent phenomena; to name some, can have a natural accounting via
interactions, which we therefore seek to incorporate by expanding the horizons
of `chemistry-only' approaches to the origins of life. It is suggested that the
magnetic 'face' of the minerals from the inorganic world, recognized to have
played a pivotal role in initiating Life, may throw light on some of these
issues. A magnetic environment in the form of rocks in the Hadean Ocean could
have enabled the accretion and therefore an ordered confinement of
super-paramagnetic colloids within a structured phase. A moderate H-field can
help magnetic nano-particles to not only overcome thermal fluctuations but also
harness them. Such controlled dynamics brings in the possibility of accessing
quantum effects, which together with frustrations in magnetic ordering and
hysteresis (a natural mechanism for a primitive memory) could throw light on
the birth of biological information which, as Abel argues, requires a
combination of order and complexity. This scenario gains strength from
observations of scale-free framboidal forms of the greigite mineral, with a
magnetic basis of assembly. And greigite's metabolic potential plays a key role
in the mound scenario of Russell and coworkers-an expansion of which is
suggested for including magnetism.Comment: 42 pages, 5 figures, to be published in A.R. Memorial volume, Ed
Krishnaswami Alladi, Springer 201
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