精神科アウトカムシステム（PSYCHOMS®）を基にした看護管理分析式の信頼性の検証および臨床での有効性の評価

In psychiatric hospitals, the ratios between patients versus physician and patients versus nurse are low as compared to those in general hospitals. Furthermore, usages of electronic medical records are also low so that nurse administrators are limited in their ability to compile, analyze, and generate patient care staffing information for their administrative use. Psychiatric nurse administrators anticipate the development of a nursing administration analysis system that could perform personnel data simulation, manage information on nursing staff, and manage ward/ practice operations. Responding to this situation, the authors developed a nursing administration analysis system utilizing formulae from the Psychiatric Outcome Management System, PSYCHOMS® to aid nurse administrators. Such formulae are awaiting patent approval. The purpose of this study was to examine the validity of the formulae and the Structured Query Language (SQL) statement, and its practical effectiveness of analyzing data. The study findings showed that two kinds of computation expressions—a classification and extraction were able to display required information desired by nurse administrators. Moreover, significant information critical to assigning staff was validated to ensure high quality of nursing care according to the function and characteristic of the hospital ward

Living with Diversity Vol. I: 8-9 November 2008, University of Ljubljana

oai:ojs.hass.tsukuba.ac.jp:article/1Living with Diversity, volume I, documents the proceedings of the Slovenia-Japan University Cooperation Network Graduate Student Forum Series held at Ljubljana University in 2008. The proceedings comprise the individual research papers as well as detailed reports of the three discussion sessions. While the individual papers discuss issues from each researcher’s specific field of expertise within the federating theme, the three discussion sessions address a wide range of issues and problems concerning identity, society and language from an essentially trans-disciplinary perspective. 『多様性を生きる』第1巻は、2008年にリュブリャナ大学において開催された「スロベニア・日本学生知的交流会議」の報告書です。本報告書は、個々の論文および3つのディスカッション・セッションの詳報を収めています。各論文においては、統一テーマの枠内で、研究者が各自の専門領域から問題を論じているのに対して、3つのディスカッション・セッションにおいては、本質的に領域横断的な視点から、アイデンティティ、社会、言語に関する広範な論点と課題を取り上げています

Transdisciplinary Joint Seminar Studies: Conflits et Interprétations

This report details the research activity carried out from 2009 to date under the Transdisciplinary Joint Seminar Studies of the universities of Aoyama Gakuin, Franche-Comté and Tsukuba. Through study sessions and conferences as well as individual research papers, the issue of conflict and interpretation is addressed across the specific fields of study from the three distinct considerations of circulation, representation and language. 要旨本報告は2009年から現在まで「青山学院大学・フランシュコンテ大学・筑波大学異分野共同セミナー」において行われた研究活動をまとめたものである。分科会、講演、ならびに個々の論文において論じられた「循環」「表象」「言語」の考察を通じて、「衝突」と「解釈」をめぐる諸問題が検証される

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Separation of the blood coagulation factor IX

小特集　バイオテクノロジ

Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF

BACKGROUND: Many patients with atrial fibrillation have concomitant coronary artery disease with or without acute coronary syndromes and are in need of additional antithrombotic therapy. There are few data on the long-term clinical outcome of atrial fibrillation patients with a history of acute coronary syndrome. This is a 2-year study of atrial fibrillation patients with or without a history of acute coronary syndromes