21 research outputs found
<Abstract of published report>Reactions of Azathiabenzene Anion with Electrophiles. Formation and X-Ray Analysis of Novel Heterocyclic Compounds from the Reaction with Carboxylic Esters.
<Abstract of published report>Reactions of 9-Substituted 9-Thia-10-azaphenanthrenes with Electrophiles.
<Abstract of published report>Reactions of 9-Substituted 9-Thia-10-azaphenanthrenes with Electrophiles.
<Abstract of published report>Thermal Rearrangement of 9-Benzyl-10-aza-9-thiaphenanthrenes.
<Abstract of published report>Reactions of Azathiabenzene Anion with Electrophiles. Formation and X-Ray Analysis of Novel Heterocyclic Compounds from the Reaction with Carboxylic Esters.
<Abstract of published report>Syntheses and Thermal Behaviour of 9-Substiuted 9-Thia-10-azaphenanthrenes.
B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling
Hepatitis C virus (HCV) infection leads to the development of hepatic diseases, as well as extrahepatic disorders such as B-cell non-Hodgkin's lymphoma (B-NHL). To reveal the molecular signalling pathways responsible for HCV-associated B-NHL development, we utilised transgenic (Tg) mice that express the full-length HCV genome specifically in B cells and develop non-Hodgkin type B-cell lymphomas (BCLs). The gene expression profiles in B cells from BCL-developing HCV-Tg mice, from BCL-non-developing HCV-Tg mice, and from BCL-non-developing HCV-negative mice were analysed by genome-wide microarray. In BCLs from HCV-Tg mice, the expression of various genes was modified, and for some genes, expression was influenced by the gender of the animals. Markedly modified genes such as Fos, C3, LTβR, A20, NF-κB and miR-26b in BCLs were further characterised using specific assays. We propose that activation of both canonical and alternative NF-κB signalling pathways and down-regulation of miR-26b contribute to the development of HCV-associated B-NHL