The Role of Spin Anisotropy in the Unbinding of Interfaces

We study the ground state of a classical X-Y model with $p \ge 3$-fold spin anisotropy $D$ in a uniform external field, $H$. An interface is introduced into the system by a suitable choice of boundary conditions. For large $D$, as $H \to 0$, we prove using an expansion in $D^{-1}$ that the interface unbinds from the surface through an infinite series of layering transitions. Numerical work shows that the transitions end in a sequence of critical end points.Comment: 7 pages RevTeX, plus 1 postscript figure available from the authors OUTP-94-41

Holographic field theory models of dark energy in interaction with dark matter

We discuss two lagrangian interacting dark energy models in the context of the holographic principle. The potentials of the interacting fields are constructed. The models are compared with CMB distance information, baryonic acoustic oscilations, lookback time and the Constitution supernovae sample. For both models the results are consistent with a non vanishing interaction between dark sectors - with more than three standard deviations of confidence for one of them. Moreover, in both cases, the sign of coupling is consistent with dark energy decaying into dark matter, alleviating the coincidence problem.Comment: arXiv admin note: substantial text overlap with arXiv:0912.399

Development of an automated microscale platform for conjugate vaccine production in E. coli

The current state-of-the-art for the production of glycoconjugate vaccines is a lengthy and complex series of process steps. An exciting alternative is Protein Glycan Coupling Technology (PGCT), where glycoconjugates are produced in vivo 1,2. This offers a significant reduction in the time and cost burden of glycoconjugate production, making this technology much more feasible for providing vaccines in developing countries. Current research seeks to apply this technology for pneumococcal vaccines 2, however much process optimisation must be done before this is achievable. This work seeks to provide an automated screening platform at the microscale, enabling the rapid screening of different process variables at considerably smaller volumes Please click Download on the upper right corner to see the full abstract

Surface spin-flop phases and bulk discommensurations in antiferromagnets

Phase diagrams as a function of anisotropy D and magnetic field H are obtained for discommensurations and surface states for a model antiferromagnet in which $H$ is parallel to the easy axis. The surface spin-flop phase exists for all $D$. We show that there is a region where the penetration length of the surface spin-flop phase diverges. Introducing a discommensuration of even length then becomes preferable to reconstructing the surface. The results are used to clarify and correct previous studies in which discommensurations have been confused with genuine surface spin-flop states.Comment: 4 pages, RevTeX, 2 Postscript figure

Role of Secondary Motifs in Fast Folding Polymers: A Dynamical Variational Principle

A fascinating and open question challenging biochemistry, physics and even geometry is the presence of highly regular motifs such as alpha-helices in the folded state of biopolymers and proteins. Stimulating explanations ranging from chemical propensity to simple geometrical reasoning have been invoked to rationalize the existence of such secondary structures. We formulate a dynamical variational principle for selection in conformation space based on the requirement that the backbone of the native state of biologically viable polymers be rapidly accessible from the denatured state. The variational principle is shown to result in the emergence of helical order in compact structures.Comment: 4 pages, RevTex, 4 eps figure

A complete devil's staircase in the Falicov-Kimball model

We consider the neutral, one-dimensional Falicov-Kimball model at zero temperature in the limit of a large electron--ion attractive potential, U. By calculating the general n-ion interaction terms to leading order in 1/U we argue that the ground-state of the model exhibits the behavior of a complete devil's staircase.Comment: 6 pages, RevTeX, 3 Postscript figure

Intrafamily and intragenomic conflicts in human warfare

A.J.C.M. is supported by a Ph.D. studentship from the School of Biology, University of St Andrews, and A.G. is supported by a Natural Environment Research Council Independent Research Fellowship (NE/K009524/1).Recent years have seen an explosion of multidisciplinary interest in ancient human warfare. Theory has emphasised a key role for kin-selected cooperation, modulated by sex-specific demography, in explaining intergroup violence. However, conflicts of interest remain a relatively underexplored factor in the evolutionary-ecological study of warfare, with little consideration given to which parties influence the decision to go to war and how their motivation may differ. We develop a mathematical model to investigate the interplay between sex-specific demography and human warfare, showing that: the ecology of warfare drives the evolution of sex-biased dispersal; sex-biased dispersal modulates intrafamily and intragenomic conflicts in relation to warfare; intragenomic conflict drives parent-of-origin-specific patterns of gene expression – i.e. 'genomic imprinting' – in relation to warfare phenotypes; and an ecological perspective of conflicts at the levels of the gene, individual and social group yields novel predictions as to pathologies associated with mutations and epimutations at loci underpinning human violence.Publisher PDFPeer reviewe