PRIMARY ACTINOMYCOSIS of the URINARY-BLADDER

ESCOLA PAULISTA MED,DEPT GYNECOL,RUA SILVA JARDIM,133 APTO 32,BR-03057070 São Paulo,BRAZILESCOLA PAULISTA MED,DEPT GYNECOL,RUA SILVA JARDIM,133 APTO 32,BR-03057070 São Paulo,BRAZILWeb of Scienc

MENOPAUSAL GENUINE STRESS URINARY-INCONTINENCE TREATED WITH CONJUGATED ESTROGENS PLUS PROGESTOGENS

Objective: the aim of the study was to investigate clinically and urodynamically the effects of hormonal replacement in the treatment of genuine stress urinary incontinence in postmenopausal females. Methods: Clinical and urodynamic variables of 30 postmenopausal women with genuine stress urinary incontinence were evaluated after 3 months' treatment with conjugated estrogens plus progestogens. Urodynamic evaluations were performed in all patients before and after treatment. Results: Forty-six percent of the patients treated medically were judged to be cured and 43% were judged to be markedly improved. Maximum urethral closure pressure, maximum cystometric capacity and mean flow were significantly increased. Residual urine and diurnal and nocturnal voluntary micturition were markedly decreased (P < 0.05). Conclusion: We conclude that hormone replacement in the form of conjugated estrogens plus progestogens results in the clinical and urodynamic improvement of genuine stress urinary incontinence in postmenopausal women.São Paulo HOSP,ESCOLA PAULISTA MED,DISCIPLINE GYNECOL,AV ONZE JUNHO 1006,APT 22,VILA CLEMENTINO,BR-04041003 São Paulo,BRAZILSão Paulo HOSP,ESCOLA PAULISTA MED,DISCIPLINE GYNECOL,AV ONZE JUNHO 1006,APT 22,VILA CLEMENTINO,BR-04041003 São Paulo,BRAZILWeb of Scienc

Doppler velocimetry parameters of periurethral vessels in postmenopausal incontinent women receiving estrogen replacement

Estrogen deficit causes significant alterations in the lower urinary tract of women, largely affecting urinary continence mechanisms. the urethral vascular bed accounts for about one-third of urethral pressure, and as it undergoes marked hormonal influence we became interested in investigating its behaviour both prior to and during estrogen replacement. We selected 25 postmenopausal patients with urinary stress incontinence and studied the periurethral vessels by means of Doppler velocimetry, analyzing the number of vessels, systolic peak, minimum diastole, resistance and pulsatility indexes and the A/B ratio, prior to estrogen replacement and after 1 and 3 months of hormone use. We concluded that estrogen replacement alone in postmenopausal women with urinary stress incontinence increased the number of periurethral vessels, systolic peak and minimum diastole; however, a trend of no statistical significance towards the reduction of resistance and pulsatility rates of periurethral vessels was found; nor was a significant difference in the A/B ratio shown.Universidade Federal de São Paulo, Escola Paulista Med, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, BrazilWeb of Scienc

Effects of tamoxifen on Doppler velocimetry parameters of periurethral vessels in postmenopausal women

The purpose of the present study was to assess the effect of tamoxifen on periurethral vessels by Doppler velocimetry examination. Increase in the number of these vessels as well as decrease in resistance and pulsatility indices by tamoxifen were observed.Universidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, BR-04040033 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, BR-04040033 São Paulo, BrazilWeb of Scienc

The impact of pregnancy and childbirth in the urethra of female rats

The aim of this study was to evaluate the modifications in the amount of collagen, muscular, and elastic fibers in the mid-urethra of adult female rats during the pregnancy and after the natural childbirth, cesarean, and after simulated trauma of childbirth. The authors evaluated the histomorphometric aspects (collagen, muscular, and elastic fibers) in the mid.-urethra of 70 animals distributed in seven groups: group 1 (n=10)-control, group 2 (n=10)pregnant female rats, group 3 (n=10)-female rats submitted to cesarean, group 4 (n=10)-female rats with natural childbirth, group 5 (n=10)-virgin female rats with simulated trauma of childbirth, group 6 (n=10)-female rats submitted to cesarean followed by simulation of childbirth trauma, and group 7 (n=10)-female rats with natural childbirth followed by simulation of childbirth trauma. The average concentration of collagen and elastic fibers and the collagen/muscular fiber correlation in groups 1, 2, and 3 were similar and significantly inferior to groups 4, 5, 6, and 7. The average of muscular fibers was similar in groups 1, 2, and 3 and significantly superior to groups 4, 5, 6, and 7. Pregnancy and cesarean did not induce alterations in collagen, muscular, and elastic fibers. However, the vaginal delivery and simulation of childbirth trauma determined the decrease in muscular fibers and the increase in collagen and elastic fibers and the correlation collagen/ muscular fiber.18664565

Impact of pregnancy and childbirth on female rats' urethral nerve fibers

This study aims to evaluate the urethral nerve fibers of adult female rats during pregnancy and after vaginal birth, cesarean section or simulated birth trauma. For immunohistochemical analysis of nerve fibers, 70 female rats were distributed in seven groups of ten female rats: group 1, control; group 2, pregnant; group 3, cesarean section; group 4, vaginal birth; group 5, virgin female rats with simulated birth trauma; group 6, cesarean section followed by simulation of birth trauma; and group 7, vaginal birth followed by simulation of birth trauma. The number of nerve fibers in groups 1, 2, and 3 were significantly higher than the other groups. Pregnancy and cesarean section did not cause alterations in the nerve fibers number. Vaginal birth and simulated birth trauma significantly decreased the number of nerve fibers in the female rats' middle urethra.18121453145