HealthCall for the smartphone: technology enhancement of brief intervention in HIV alcohol dependent patients

Background: Heavy drinking jeopardizes the health of patients in HIV primary care. In alcohol dependent patients in HIV primary care, a technological enhancement of brief intervention, HealthCall administered via interactive voice response (HealthCall-IVR) was effective at reducing heavy drinking. The smartphone offered a technology platform to improve HealthCall. Methods: Working with input from patients, technology experts, and HIV clinic personnel, we further developed HealthCall, harnessing smartphone technological capacities (HealthCall-S). In a pilot study, we compared rates of HealthCall-S daily use and drinking outcomes in 41 alcohol dependent HIV-infected patients with the 43 alcohol dependent HIV-infected patients who used HealthCall-IVR in our previous efficacy study. Procedures, clinic, personnel, and measures were largely the same in the two studies, and the two groups of patients were demographically similar (~90% minority). Results: Pilot patients used HealthCall-S a median of 85.0% of the 60 days of treatment, significantly greater than the corresponding rate (63.8%) among comparison patients using HealthCall-IVR (p < .001). Mean end-of-treatment drinks per drinking day was similar in the two groups. Patients were highly satisfied with HealthCall-S (i.e., 92% reported that they liked using HealthCall-S). Conclusions: Among alcohol dependent patients in HIV primary care, HealthCall delivered via smartphone is feasible, obtains better patient engagement than HealthCall-IVR, and is associated with decreased drinking. In HIV primary care settings, HealthCall-S may offer a way to improve drinking outcomes after brief intervention by extending patient engagement with little additional demands on staff time

Vampires in the village Žrnovo on the island of Korčula: following an archival document from the 18th century

Središnja tema rada usmjerena je na raščlambu spisa pohranjenog u Državnom arhivu u Mlecima (fond: Capi del Consiglio de’ Dieci: Lettere di Rettori e di altre cariche) koji se odnosi na događaj iz 1748. godine u korčulanskom selu Žrnovo, kada su mještani – vjerujući da su se pojavili vampiri – oskvrnuli nekoliko mjesnih grobova. U radu se podrobno iznose osnovni podaci iz spisa te rečeni događaj analizira u širem društvenom kontekstu i prate se lokalna vjerovanja.The main interest of this essay is the analysis of the document from the State Archive in Venice (file: Capi del Consiglio de’ Dieci: Lettere di Rettori e di altre cariche) which is connected with the episode from 1748 when the inhabitants of the village Žrnove on the island of Korčula in Croatia opened tombs on the local cemetery in the fear of the vampires treating. This essay try to show some social circumstances connected with this event as well as a local vernacular tradition concerning superstitions

[Cp2ZrMe(12-mu-Me-1-closo-CB11HMe10)]: a transition metal complex of a highly-methylated carborane anion.

[Cp2ZrMe(12-mu-Me-1-closo-CB11HMe10), isolated by methide abstraction from Cp2ZrMe2 using [CPh3][closo-HCB11Me11] displays an intermolecular Zr...H3C interaction in both the solid state and solution

CCDC 209456: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

Silver-phosphine complexes of the highly methylated carborane monoanion [closo-1-H-CB11M11](-)

The synthesis of the silver(l) salt of the highly methylated carborane anion [closo-1-H-CB11-Me-11](-) is described, Ag[closo-1-H-CB11Me11] 1, which in the solid state shows close intermolecular Ag...H3C contacts. Addition of various monodentate phosphines to 1 results in the formation of the complexes (R3P)-Ag[closo-1-H-CB11Me11] [R = Ph, 2; cyclohexyl (C6H11), 3; (3,5-Me-2-C6H3), 4]. All these complexes show close intermolecular Ag...H3C contacts in the solid state that are considerably shorter than the sum of the van der Waals radius of methyl (2.00 Angstrom) and the ionic radius of silver(l) (1.29 Angstrom). For 2 and 3 there are other close intermolecular Ag...H3C contacts in the solid state, arising from proximate carborane anions in the crystal lattice. Addition of methyl groups to the periphery of the phosphine ligand (complex 4) switches off the majority of these interactions, leaving essentially a single cage interacting with the cationic silver-phosphine fragment through three CH3 groups. In solution (CD2Cl2) Ag...H3C contacts remain, as evidenced by both the downfield chemical shift change and the significant line-broadening observed for the cage methyl signals. These studies also show that the metal fragment is fluxional over the surface of the cage. The Ag...H3C interactions in solution may be switched off by addition of a stronger Lewis base than [closo-1-H-CB11Me11](-). Thus, addition of [NBu4][closo-1-H-CB11H5Br6] to 2 affords (Ph3P)Ag[closo-1-H-CB11H5Br6], while adding Et2O or PPh3 affords the well-separated ion-pairs [(Ph3P)(L)Ag][closo-1-H-CB11Me11] (L = OEt2 5, PPh3 6,) both of which have been crystallographically characterized. DFT calculations on 2 (at the B3LYP/DZVP level) show small energy differences between the possible coordination isomers of this compound, with the favored geometry being one in which the {(Ph3P)Ag}(+) fragment interacts with three of the {BCH3} vertices on the lower surface of the cage, similar to the experimentally observed structure of4

CCDC 232714: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

CCDC 232713: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures