Coal mine dangerous gas inspection system based on multi-sensor fusion

A coal mine dangerous gas inspection system based on multi-sensor fusion technology is designed. The overall architecture of the system is divided into execution layer, network layer and decision layer. The monitoring platform and server in the decision layer and the mobile inspection robot in the execution layer realize data transmission through the network layer. This paper introduces the process of dangerous gas inspection and the module composition and function classification of inspection robot. The intelligent sensing module of the robot has the corresponding environmental parameter monitoring function. The robot can realize autonomous navigation and obstacle avoidance and dangerous gas concentration data acquisition by carrying a variety of sensors. The BP neural network algorithm is used to realize multi-sensor fusion, The real-time monitoring of various dangerous gas concentrations in coal mine underground environment is completed

Molecular mechanisms of cadmium-induced cytotoxicity in human ovarian granulosa cells identified using integrated omics

Epidemiological and clinical data have demonstrated that exposure to cadmium (Cd), a toxic heavy metal, is associated with an increased risk of female infertility. Granulosa cells, the main somatic cells comprising ovarian follicles, are one of the main targets of Cd in the ovaries. However, the mechanism by which Cd induces cytotoxicity in granulosa cells has not been fully elucidated. In this study, we exposed human ovarian granulosa cells (KGN cells) to Cd and conducted in vitro cell experiments and multi-omics (metabolomics and transcriptomics) methods to elucidate these mechanisms. Cd exposure was found to not only induce the apoptosis of the KGN cells but also further reduced mitochondrial function by decreasing mitochondrial membrane potential, ATP production, and respiratory chain complex activity as well as increasing mitochondrial reactive oxygen species (ROS) production. A total of 443 differentially expressed metabolites (160 upregulated and 283 downregulated) and 5200 differentially expressed genes (4634 upregulated and 566 downregulated) were observed in the Cd exposed-cells. The multi-omics data showed that Cd interfered with citric acid cycle (TCA cycle), amino acid (including alanine, glycine, serine, threonine, arginine, and proline) metabolism, and calcium signaling. These findings help to better elucidate the potential toxicity mechanisms of Cd on granulosa cells and the ovary

Management and control mode of underground coal mining based on medium and high-level intelligent technology

Coal is the guarantee energy in China, and its dominant position in energy will not change for a period of time in the future. Coal intelligent mining will show a rapid development trend and enter into a new stage of development. Through induction and analysis, the great significance, development law, contradiction, construction method and future development direction of intelligent construction of coal mine are summarized in this paper. This paper systematically expounds the reform process of coal mining technology and management mode in China, and summarizes the five stages of manual mining, ordinary mining, comprehensive mechanized mining, automatic mining, primary intelligent mining, as well as the corresponding technical modes. Breaking through the intelligent research ideas such as traditional coal roadheader mining, this paper puts forward 10 characteristics of medium and high-level intelligent mining technology of coal, namely, complete transparency of coal mine, comprehensive intelligence of perception, high-end intelligence of equipment, real-time reliability of network, integrated platform control, intelligent analysis of data, group collaboration intelligence, professional team employees, dynamic decision-making intelligence, disaster prevention and control matching, and gives the definition, characteristics, content and function of each characteristic. Based on the premise of medium and high-level intelligent technology, the corresponding ‘1+1’ management and control mode of coal mine mining is conceived, that is, one level is set in one coal mine, and a new flat platform management and control mode of ‘one command and control center+one professional team’ is constructed. Therefore, the mode can promote the reform of production mode, match the requirements of corresponding mining mode in the future intelligent rapid development and realize the real meaning of reducing personnel, increasing safety and improving efficiency. Finally, the further development of intelligent mining technology and mode in coal mine is prospected

Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-κB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation

Pulmonary fibrosis (PF) is one of the sequelae of Corona Virus Disease 2019 (COVID-19), and currently, lung transplantation is the only viable treatment option. Hence, other effective treatments are urgently required. We investigated the therapeutic effects of an approved botanical drug, cepharanthine (CEP), in a cell culture model of transforming growth factor-β1 (TGF-β1) and bleomycin (BLM)-induced pulmonary fibrosis rat models both in vitro and in vivo. In this study, CEP and pirfenidone (PFD) suppressed BLM-induced lung tissue inflammation, proliferation of blue collagen fibers, and damage to lung structures in vivo. Furthermore, we also found increased collagen deposition marked by α-smooth muscle actin (α-SMA) and Collagen Type I Alpha 1 (COL1A1), which was significantly alleviated by the addition of PFD and CEP. Moreover, we elucidated the underlying mechanism of CEP against PF in vitro. Various assays confirmed that CEP reduced the viability and migration and promoted apoptosis of myofibroblasts. The expression levels of myofibroblast markers, including COL1A1, vimentin, α-SMA, and Matrix Metallopeptidase 2 (MMP2), were also suppressed by CEP. Simultaneously, CEP significantly suppressed the elevated Phospho-NF-κB p65 (p-p65)/NF-κB p65 (p65) ratio, NOD-like receptor thermal protein domain associated protein 3 (NLRP3) levels, and elevated inhibitor of NF-κB Alpha (IκBα) degradation and reversed the progression of PF. Hence, our study demonstrated that CEP prevented myofibroblast activation and treated BLM-induced pulmonary fibrosis in a dose-dependent manner by regulating nuclear factor kappa-B (NF-κB)/ NLRP3 signaling, thereby suggesting that CEP has potential clinical application in pulmonary fibrosis in the future

Integrating genomic and multiomic data for <i>Angelica sinensis</i> provides insights into the evolution and biosynthesis of pharmaceutically bioactive compounds

Angelica sinensis roots (Angelica roots) are rich in many bioactive compounds, including phthalides, coumarins, lignans, and terpenoids. However, the molecular bases for their biosynthesis are still poorly understood. Here, an improved chromosome-scale genome for A. sinensis var. Qinggui1 is reported, with a size of 2.16 Gb, contig N50 of 4.96 Mb and scaffold N50 of 198.27 Mb, covering 99.8% of the estimated genome. Additionally, by integrating genome sequencing, metabolomic profiling, and transcriptome analysis of normally growing and early-flowering Angelica roots that exhibit dramatically different metabolite profiles, the pathways and critical metabolic genes for the biosynthesis of these major bioactive components in Angelica roots have been deciphered. Multiomic analyses have also revealed the evolution and regulation of key metabolic genes for the biosynthesis of pharmaceutically bioactive components; in particular, TPSs for terpenoid volatiles, ACCs for malonyl CoA, PKSs for phthalide, and PTs for coumarin biosynthesis were expanded in the A. sinensis genome. These findings provide new insights into the biosynthesis of pharmaceutically important compounds in Angelica roots for exploration of synthetic biology and genetic improvement of herbal quality

Determination of the number of ψ(3686)\psi(3686) events at BESIII

The numbers of ψ(3686) events accumulated by the BESIII detector for the data taken during 2009 and 2012 are determined to be and , respectively, by counting inclusive hadronic events, where the uncertainties are systematic and the statistical uncertainties are negligible. The number of events for the sample taken in 2009 is consistent with that of the previous measurement. The total number of ψ(3686) events for the two data taking periods is