Spatial-Temporal Variation Characteristics and Cause Analysis of Water Quality in Yinma River Basin

In order to comprehensively understand the water quality in Yinma River Basin, and to analyze the spatial-temporal variation characteristics of water quality over the years and the causes of water pollution, 15 sections were selected in the Yinma River Basin. Based on the water quality monitoring data in the past decade, 7 evaluation indexes including dissolved oxygen (DO), 5-day biochemical oxygen demand (BOD5), permanganate index (CODMN), chemical oxygen demand (COD), ammonia nitrogen (NH4-N), total phosphorus (TP) and total nitrogen (TN) were determined, according to the Environmental Quality Standard for Surface Water (GB3838-2002) and the historical monitoring data of rivers. The water quality of 15 sections in Yinma River Basin was comprehensively evaluated, and the water quality categories and the evolution of river water quality were analyzed. The pollution sources of Yinma River Basin were analyzed, and the constructive countermeasures were put forward according to the conclusions

Towards a Framework for Developing Verified Assemblers for the ELF Format (Artifact)

This is the artifact for the APLAS 2023 paper "Towards a Framework for Developing Verified Assemblers for the ELF Format". This artifact contains the implmentation and applications of our framework introduced in the paper, which is based on CompCert v3.8. There is a 'README.md' file in the main directory instructing how to build the code

Lactylation stabilizes DCBLD1 activating the pentose phosphate pathway to promote cervical cancer progression

Abstract Background Discoidin, CUB, and LCCL domain-containing type I (DCBLD1) is identified as an oncogene involved in multiple regulation of tumor progression, but specific mechanisms remain unclear in cervical cancer. Lactate-mediated lactylation modulates protein function. Whether DCBLD1 can be modified by lactylation and the function of DCBLD1 lactylation are unknown. Therefore, this study aims to investigate the lactylation of DCBLD1 and identify its specific lactylation sites. Herein, we elucidated the mechanism by which lactylation modification stabilizes the DCBLD1 protein. Furthermore, we investigated DCBLD1 overexpression activating pentose phosphate pathway (PPP) to promote the progression of cervical cancer. Methods DCBLD1 expression was examined in human cervical cancer cells and adjacent non-tumorous tissues using quantitative reverse transcription-polymerase chain reaction, western blotting, and immunohistochemistry. In vitro and in vivo studies were conducted to investigate the impact of DCBLD1 on the progression of cervical cancer. Untargeted liquid chromatography-tandem mass spectrometry (LC–MS/MS) metabolomics studies were used to characterize DCBLD1-induced metabolite alterations. Western blot, immunofuorescence and transmission electron microscopy were performed to detect DCBLD1 degradation of G6PD by activating autophagy. Chromatin immunoprecipitation, dual luciferase reporter assay for detecting the mechanism by which lactate increases DCBLD1 transcription. LC–MS/MS was employed to verify specific modification sites within the DCBLD1 protein. Results We found that lactate increased DCBLD1 expression, activating the PPP to facilitate the proliferation and metastasis of cervical cancer cells. DCBLD1 primarily stimulated PPP by upregulating glucose-6-phosphate dehydrogenase (G6PD) expression and enzyme activity. The mechanism involved the increased enrichment of HIF-1α in the DCBLD1 promoter region, enhancing the DCBLD1 mRNA expression. Additionally, lactate-induced DCBLD1 lactylation stabilized DCBLD1 expression. We identified DCBLD1 as a lactylation substrate, with a predominant lactylation site at K172. DCBLD1 overexpression inhibited G6PD autophagic degradation, activating PPP to promote cervical cancer progression. In vivo, 6-An mediated inhibition of G6PD enzyme activity, inhibiting tumor proliferation. Conclusions Our findings revealed a novel post-translational modification type of DCBDL1, emphasizing the significance of lactylation-driven DCBDL1-mediated PPP in promoting the progression of cervical cancer. Graphical Abstract Schematic illustration of DCBLD1-induced G6PD-mediated reprogramming of PPP metabolism in promoting cervical cancer progression

Circularly polarized terahertz wave independently controlled tunable spin-decoupled metasurface

The research and development of multifunctional metasurfaces has attracted much attention, and manipulating multifunctional devices with greater degrees of freedom is a continuing trend. In this study, we propose a tunable multifunctional metasurface with terahertz (THz) frequency and demonstrate it theoretically. By introducing the propagation phase decoupling conjugate response, we realize the independent control of beam deflection(deflection angle is 8.1°), beam splitting（split angle is 16.5°）, and vortex beam mode switching under different incident conditions. At the same time, by changing the Fermi level of the Dirac semimetal, the switching between different states under the same incident condition is realized. The results of this study are expected to contribute to promising applications in future for improving the capacity of THz communication systems, independently regulating multi-functional devices