380 research outputs found
Protecting eyewitness evidence: Examining the efficacy of a self-administered interview tool
Given the crucial role of eyewitness evidence, statements should be obtained as soon as possible after an incident. This is not always achieved due to demands on police resources. Two studies trace the development of a new tool, the Self-Administered Interview (SAI), designed to elicit a comprehensive initial statement. In Study 1, SAI participants reported more correct details than participants who provided a free recall account, and performed at the same level as participants given a Cognitive Interview. In Study 2, participants viewed a simulated crime and half recorded their statement using the SAI. After a delay of 1 week, all participants completed a free recall test. SAI participants recalled more correct details in the delayed recall task than control participants
The role of chaotic resonances in the solar system
Our understanding of the Solar System has been revolutionized over the past
decade by the finding that the orbits of the planets are inherently chaotic. In
extreme cases, chaotic motions can change the relative positions of the planets
around stars, and even eject a planet from a system. Moreover, the spin axis of
a planet-Earth's spin axis regulates our seasons-may evolve chaotically, with
adverse effects on the climates of otherwise biologically interesting planets.
Some of the recently discovered extrasolar planetary systems contain multiple
planets, and it is likely that some of these are chaotic as well.Comment: 28 pages, 9 figure
New predictors of malignant ventricular arrhythmias in Chagas disease: searching for the holy grail
Quantitative Modeling of Escherichia coli Chemotactic Motion in Environments Varying in Space and Time
Escherichia coli chemotactic motion in spatiotemporally varying environments is studied by using a computational model based on a coarse-grained description of the intracellular signaling pathway dynamics. We find that the cell's chemotaxis drift velocity vd is a constant in an exponential attractant concentration gradient [L]∝exp(Gx). vd depends linearly on the exponential gradient G before it saturates when G is larger than a critical value GC. We find that GC is determined by the intracellular adaptation rate kR with a simple scaling law: . The linear dependence of vd on G = d(ln[L])/dx directly demonstrates E. coli's ability in sensing the derivative of the logarithmic attractant concentration. The existence of the limiting gradient GC and its scaling with kR are explained by the underlying intracellular adaptation dynamics and the flagellar motor response characteristics. For individual cells, we find that the overall average run length in an exponential gradient is longer than that in a homogeneous environment, which is caused by the constant kinase activity shift (decrease). The forward runs (up the gradient) are longer than the backward runs, as expected; and depending on the exact gradient, the (shorter) backward runs can be comparable to runs in a spatially homogeneous environment, consistent with previous experiments. In (spatial) ligand gradients that also vary in time, the chemotaxis motion is damped as the frequency ω of the time-varying spatial gradient becomes faster than a critical value ωc, which is controlled by the cell's chemotaxis adaptation rate kR. Finally, our model, with no adjustable parameters, agrees quantitatively with the classical capillary assay experiments where the attractant concentration changes both in space and time. Our model can thus be used to study E. coli chemotaxis behavior in arbitrary spatiotemporally varying environments. Further experiments are suggested to test some of the model predictions
First report on dung beetles in intra-Amazonian savannahs in Roraima, Brazil
This is the first study to address the dung beetle (Coleoptera: Scarabaeidae: Scarabaeinae) diversity in intra-Amazonian savannahs in the state of Roraima, Brazil. Our aim was to survey the dung beetle fauna associated with these savannahs (regionally called 'lavrado'), since little is known about the dung beetles from this environment. We conducted three field samples using pitfall traps baited with human dung in savannah areas near the city of Boa Vista during the rainy seasons of 1996, 1997, and 2008. We collected 383 individuals from ten species, wherein six have no previous record in intra-Amazonian savannahs. The most abundant species were Ontherus appendiculatus (Mannerheim, 1829), Canthidium aff. humerale (Germar, 1813), Dichotomius nisus (Olivier, 1789), and Pseudocanthon aff. xanthurus (Blanchard, 1846). We believe that knowing the dung beetles diversity associated with the intra-Amazonian savannahs is ideal for understanding the occurrence and distribution of these organisms in a highly threatened environment, it thus being the first step towards conservation strategy development
Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour
available in PMC 2012 June 22.Heritable variation in behavioural traits generally has a complex genetic basis1, and thus naturally
occurring polymorphisms that influence behaviour have been defined in only rare instances2,3.
The isolation of wild strains of Caenorhabditis elegans has facilitated the study of natural genetic
variation in this species4 and provided insights into its diverse microbial ecology5. C. elegans
responds to bacterial infection with conserved innate immune responses6-8 and, while lacking the
immunological memory of vertebrate adaptive immunity, exhibits an aversive learning response to
pathogenic bacteria9. Here, we report the molecular characterization of naturally occurring coding
polymorphisms in a C. elegans gene encoding a conserved HECT domain-containing E3 ubiquitin
ligase, HECW-1. We show that two distinct polymorphisms in neighbouring residues of HECW-1
each affect C. elegans behavioural avoidance of a lawn of Pseudomonas aeruginosa. Neuronspecific
rescue and ablation experiments, and genetic interaction analysis suggest that HECW-1
functions in a pair of sensory neurons to inhibit P. aeruginosa lawn avoidance behaviour through
inhibition of the neuropeptide receptor NPR-110, which we have previously shown promotes P.
aeruginosa lawn avoidance behaviour11. Our data establish a molecular basis for natural variation
in a C. elegans behaviour that may undergo adaptive changes in response to microbial pathogens.National Institutes of Health (U.S.) (NIH Grant GM084477
Idosos de Florianópolis: autopercepção das condições de saúde bucal e utilização de serviços odontológicos
Potential of entomopathogenic nematodes of the genus Heterorhabditis for the control of Stomoxys calcitrans (Diptera: Muscidae)
Asymmetric and symmetric stem-cell divisions in development and cancer
Much has been made of the idea that asymmetric cell division is a defining characteristic of stem cells that enables them to simultaneously perpetuate themselves (self-renew) and generate differentiated progeny. Yet many stem cells can divide symmetrically, particularly when they are expanding in number during development or after injury. Thus, asymmetric division is not necessary for stem-cell identity but rather is a tool that stem cells can use to maintain appropriate numbers of progeny. The facultative use of symmetric or asymmetric divisions by stem cells may be a key adaptation that is crucial for adult regenerative capacity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62868/1/nature04956.pd
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