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In Service to the New Nation: The Life and Legacy of John Jay--Panel 4: Roundtable on The Future of Documentary Editing & the Founding Era
The John Jay Papers Project, Columbia University Libraries, and Columbia University’s Office of the Provost presented "In Service to the New Nation: The Life & Legacy of John Jay," a two-day virtual conference (January 22-23, 2021) celebrating the near completion of the Project’s seven-volume series The Selected Papers of John Jay. Featuring a keynote address and panel sessions, the conference events highlight John Jay’s (1745-1829) notable career in public service and his numerous contributions to the new American republic as a jurist, statesman, diplomat, and politician.
The "Roundtable on The Future of Documentary Editing & the Founding Era" discusses the practices and future of the documentary editing method. The chair is R. Darrell Meadows (National Historical Publications and Records Commission), and the panelists are Sara Martin (Adams Papers, Massachusetts Historical Society), Holly C. Shulman (Dolley Madison Digital Edition), Jennifer E. Steenshorne (John Jay Papers), and Jennifer Stertzer (Washington Papers, Center for Digital Editing)
A Review of Compounds Exhibiting Anti-Orthopoxvirus Activity in Animal Models
Several animal models using mice (most frequently), rabbits, or monkeys have been used to identify compounds active against orthopoxvirus infections. The treatment of vaccinia virus infections has been well studied in models involving infection of scarified skin or eyes, or resulting from intravenous, intraperitoneal, intracerebral, or intranasal virus inoculation. Cowpox virus has been used in intranasal or aerosol infection studies to evaluate the treatment of lethal respiratory infections. Rabbitpox, monkeypox, and variola viruses have been employed to a lesser extent than the other viruses in chemotherapy experiments. A review of the literature over the past 50 years has identified a number of compounds effective in treating one or more of these infections, which include thiosemicarbazones, nucleoside and nucleotide analogs, interferon, interferon inducers, and other unrelated compounds. Substances that appear to have the greatest potential as anti-orthopoxvirus agents are the acyclic nucleotides, (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (cidofovir, HPMPC) and 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine (cyclic HPMPC), and the acyclic nucleoside analog, 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine (S2242). Other classes of compounds that have not been sufficiently studied in lethal infection models and deserve further consideration are thiosemicarbazones related to methisazone, and analogs of adenosine-N1-oxide and 1-(benzyloxy)adenosine