30 research outputs found
The Thermonuclear X-Ray Bursts of 4U 1730-22
We present observations of the historic transient 4U 1730–22 as observed with the Neutron Star Interior Composition Explorer (NICER). After remaining in quiescence since its 1972 discovery, this X-ray binary showed renewed outburst activity in 2021 and 2022. We observed 4U 173–22 extensively with NICER, detecting a total of 17 thermonuclear X-ray bursts. From a spectroscopic analysis, we find that these X-ray bursts can be divided into a group of bright and weak bursts. All bright bursts showed 1–2 s rise times and a photospheric radius expansion phase, while the weak bursts showed a slower ∼5 s rise with a tendency for concave shapes. From the photospheric radius expansion flux, we estimate the source distance at 6.9 ± 0.2 kpc. We consider various interpretations for our observations and suggest that they may be explained if accreted material is burning stably at the stellar equator and unstable ignition occurs at a range of higher latitudes
Theorems on existence and global dynamics for the Einstein equations
This article is a guide to theorems on existence and global dynamics of
solutions of the Einstein equations. It draws attention to open questions in
the field. The local-in-time Cauchy problem, which is relatively well
understood, is surveyed. Global results for solutions with various types of
symmetry are discussed. A selection of results from Newtonian theory and
special relativity that offer useful comparisons is presented. Treatments of
global results in the case of small data and results on constructing spacetimes
with prescribed singularity structure or late-time asymptotics are given. A
conjectural picture of the asymptotic behaviour of general cosmological
solutions of the Einstein equations is built up. Some miscellaneous topics
connected with the main theme are collected in a separate section.Comment: Submitted to Living Reviews in Relativity, major update of Living
Rev. Rel. 5 (2002)
Use of helical computed tomography for measurement of thyroid glands in clinically normal cats
The Discovery of the 528.6 Hz Accreting Millisecond X-Ray Pulsar MAXI J1816-195
We present the discovery of 528.6 Hz pulsations in the new X-ray transient MAXI J1816-195. Using NICER, we observed the first recorded transient outburst from the neutron star low-mass X-ray binary MAXI J1816-195 over a period of 28 days. From a timing analysis of the 528.6 Hz pulsations, we find that the binary system is well described as a circular orbit with an orbital period of 4.8 hr and a projected semimajor axis of 0.26 lt-s for the pulsar, which constrains the mass of the donor star to 0.10-0.55 M (circle dot). Additionally, we observed 15 thermonuclear X-ray bursts showing a gradual evolution in morphology over time, and a recurrence time as short as 1.4 hr. We did not detect evidence for photospheric radius expansion, placing an upper limit on the source distance of 8.6 kpc
A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics
CORP: Measurement of upper and lower limb muscle strength and voluntary activation
Muscle strength, the maximal force-generating capacity of a muscle or group of muscles, is regularly assessed in physiological experiments and clinical trials. An understanding of the expected variation in strength and the factors that contribute to this variation is important when designing experiments, describing methodologies, interpreting results, and attempting to replicate methods of others and reproduce their findings. In this review (Cores of Reproducibility in Physiology), we report on the intra- and inter-rater reliability of tests of upper and lower limb muscle strength and voluntary activation in humans. Isometric, isokinetic, and isoinertial strength exhibit good intra-rater reliability in most samples (correlation coefficients ≥0.90). However, some tests of isoinertial strength exhibit systematic bias that is not resolved by familiarization. With the exception of grip strength, few attempts have been made to examine inter-rater reliability of tests of muscle strength. The acute factors most likely to affect muscle strength and serve as a source of its variation from trial-to-trial or day-to-day include attentional focus, breathing technique, remote muscle contractions, rest periods, temperature (core, muscle), time of day, visual feedback, body and limb posture, body stabilization, acute caffeine consumption, dehydration, pain, fatigue from preceding exercise, and static stretching \u3e60 s. Voluntary activation, the nervous system’s ability to drive a muscle to create its maximal force, exhibits good intra-rater reliability when examined with twitch interpolation (correlation coefficients \u3e0.80). However, inter-rater reliability has not been formally examined. The methodological factors most likely to influence voluntary activation are myograph compliance and sensitivity; stimulation location, intensity, and inadvertent stimulation of antagonists; joint angle (muscle length); and the resting twitch