congenital deafness

Discordant Hirschsprung's disease in monozygotic twins is extremely rare. A pair of monozygotic twins with congenital deafness and discordant colonic aganglionosis is presented and genetic and prenatal environmental factors are discussed

Discordant Hirschsprung's disease in monozygotic twins with concordant congenital deafness.

Discordant Hirschsprung's disease in monozygotic twins is extremely rare. A pair of monozygotic twins with congenital deafness and discordant colonic aganglionosis is presented and genetic and prenatal environmental factors are discussed

Public Health Rep

Characteristics of 190 urban community hospitals that were closed during the period 1980-87 and characteristics of the communities that they served were analyzed and compared to a control group of 380 urban hospitals that remained open. A negative association was found between hospital closure and four hospital characteristics: the presence of a cancer program approved by the American College of Surgeons, the combined characteristics of for-profit status and membership in a multi-institutional chain, the number of admissions, and the number of facilities and services offered. A positive association was found between hospital closure and the percentage of black residents in the community. These findings are discussed in the context of political and economic trends in health care and urban development. Implications for future research are noted, including managerial strategy for hospital administrators and the socioeconomic implications of hospital survival in declining urban communities.1641437PMCnul

The association of adrenocortical carcinoma and thyroid cancer in a child with Peutz-Jeghers syndrome

Peutz-Jeghers syndrome (PJS) is a rare, dominantly inherited disorder characterized by gastrointestinal hamartomatous polyps, mucocutaneous hyperpigmentation, and an increased risk of cancer. We present a 16-month-old child diagnosed with PJS, who had distinguishing features compared with the previously reported cases with respect to her clinical presentation, associated malignancies, and genetic analysis. To our knowledge, this is the first report of adrenocortical carcinoma in association with PJS, as well as the first instance of associated thyroid cancer in a child with PJS. We briefly review the relevant literature and highlight the recent progress achieved in the investigation of the syndrome. (c) 2011 Elsevier Inc. All rights reserved