Metastatic Lip Cancer of Unknown Primary

Background As housestaff, we seldom have the chance to admit a patient with cancer of unknown primary. Even if a patient presents with metastatic cancer, it is frequently evident what the primary cancer is based on epidemiology and imaging. However, in this case we have the unique opportunity of describing a metastatic cancer that presented as a lip carcinoma with several possible primary sources. Our goal is to guide the reader through the thought process involved with determining the primary malignancy in patients presenting with metastatic disease. Case Presentation A 54-year-old female with a 30-pack-year smoking history presented to the emergency department with pain and swelling of the right lower lip. The symptoms started one month ago with mild to moderate pain, and progressed within one week to signif1cant swelling. She had developed a lip abscess two weeks prior that was incised and drained, but now presented with worsening drainage, swelling, and pain She also had fevers and a non-productive cough for one month

The ALMaQUEST Survey: The Molecular Gas Main Sequence and the Origin of the Star-forming Main Sequence

The origin of the star forming main sequence ( i.e., the relation between star formation rate and stellar mass, globally or on kpc-scales; hereafter SFMS) remains a hotly debated topic in galaxy evolution. Using the ALMA-MaNGA QUEnching and STar formation (ALMaQUEST) survey, we show that for star forming spaxels in the main sequence galaxies, the three local quantities, star-formation rate surface density (\sigsfr), stellar mass surface density (\sigsm), and the \h2~mass surface density (\sigh2), are strongly correlated with one another and form a 3D linear (in log) relation with dispersion. In addition to the two well known scaling relations, the resolved SFMS (\sigsfr~ vs. \sigsm) and the Schmidt-Kennicutt relation (\sigsfr~ vs. \sigh2; SK relation), there is a third scaling relation between \sigh2~ and \sigsm, which we refer to as the `molecular gas main sequence' (MGMS). The latter indicates that either the local gas mass traces the gravitational potential set by the local stellar mass or both quantities follow the underlying total mass distributions. The scatter of the resolved SFMS ($\sigma \sim 0.25$ dex) is the largest compared to those of the SK and MGMS relations ($\sigma \sim$ 0.2 dex). A Pearson correlation test also indicates that the SK and MGMS relations are more strongly correlated than the resolved SFMS. Our result suggests a scenario in which the resolved SFMS is the least physically fundamental and is the consequence of the combination of the SK and the MGMS relations

Association between amebic liver abscess and Human Immunodeficiency Virus infection in Taiwanese subjects

<p>Abstract</p> <p>Purpose</p> <p>Invasive amebiasis is an emerging parasitic disorder in Taiwan, especially in patients diagnosed with human immunodeficiency virus (HIV) infection. Thirty-three Taiwanese subjects with amebic liver abscess (ALA) were examined and a possible correlation between ALA and HIV infection was investigated.</p> <p>Results</p> <p>Among ALA patients, the proportion of HIV-positive individuals increased during the study period. ALA was the first major clinical presentation in 54% of HIV patients with ALA. Overall, 58% (14/24) of HIV-infected patients had a CD4+ count > 200 cells/μL and 82.1% (23/28) had no concurrent opportunistic infection or other evidence of HIV infection. There was no marked difference in clinical characteristics between HIV-positive and HIV-negative ALA patients except the level of leukocytosis.</p> <p>Conclusion</p> <p>While the clinical characteristics described herein cannot be used to determine whether ALA patients have HIV infection, routine HIV testing is recommended in patients with ALA, even in the absence of HIV symptoms.</p

The mTOR Pathway Independent Function of NPRL2 in the Regulation of S-Phase DNA Damage Response

https://openworks.mdanderson.org/sumexp22/1070/thumbnail.jp

Fear, stress, susceptibility, and problematic social media use explain motivation for COVID-19 preventive behaviors among patients with stroke and their caregivers

The COVID-19 pandemic presented significant challenges for individuals who experienced stroke and their caregivers. It is essential to understand the factors affecting preventive behavior in these populations. Therefore, the present study examined the factors that influenced COVID-19 preventive behavior and motivation for COVID-19 vaccine uptake among patients with stroke and their caregivers. A cross-sectional study comprising 191 participants (81 patients with stroke and 110 caregivers) was carried out. Participants completed a survey assessing fear of COVID-19, stress, perceived susceptibility, problematic social media use, preventive behaviors, and motivation for vaccine uptake. Statistical analyses included descriptive statistics, Pearson correlations, and multiple linear regressions. Motivation for COVID-19 vaccine uptake was significantly positively correlated with problematic social media use (r = 0.225, P = .002), perceived susceptibility (r = 0.197, P = .008), and fear of COVID-19 (r = 0.179, P = .015), but negatively correlated with stress (r = −0.189, P = .010). Caregivers, compared to patients, showed a lower level of preventive behavior (standardized coefficient = −0.23, P = .017). Furthermore, higher levels of fear were associated with increased preventive behavior (standardized coefficient = 0.22, P = .006), while greater stress correlated with lower preventive behavior (standardized coefficient = −0.38, P < .001). Among patients with stroke and their caregivers, motivation of COVID-19 vaccine uptake and preventive behaviors were influenced by factors such as fear, perceived susceptibility, social media use, and stress. By using strategies such as targeted education, support, and communication campaigns, healthcare providers and policymakers may be able to enhance the well-being of patients with stroke and their caregivers during future pandemics. What do we already know about this topic? Preventive behaviors and vaccine uptake are important factors for people not to be infected by the COVID-19. How does your research contribute to the field? The present study offers significant contributions to the field by enhancing understanding of preventive behaviors during crises, specifically for patients with stroke and their caregivers. It highlights the importance of a number of factors including fear, stress, and perceived susceptibility in influencing vaccine uptake and preventive behaviors. These insights are crucial for developing targeted interventions and effective communication strategies, especially in managing psychological stressors. What are your research's implications toward theory, practice, or policy? Strategies to reduce stress and provide coping mechanisms for patients with stroke and caregivers of patients with stroke may enhance their ability to engage in preventive behaviors; additionally, healthcare providers should actively address and debunk misinformation on social media platforms to promote accurate and evidence-based information. Original Researc

ALMaQUEST. IV. The ALMA-MaNGA QUEnching and STar Formation (ALMaQUEST) Survey

The ALMaQUEST (ALMA-MaNGA QUEnching and STar formation) survey is a program with spatially-resolved $^{12}$CO(1-0) measurements obtained with the Atacama Large Millimeter Array (ALMA) for 46 galaxies selected from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) DR15 optical integral-field spectroscopic survey. The aim of the ALMaQUEST survey is to investigate the dependence of star formation activity on the cold molecular gas content at kpc scales in nearby galaxies. The sample consists of galaxies spanning a wide range in specific star formation rate (sSFR), including starburst (SB), main-sequence (MS), and green valley (GV) galaxies. In this paper, we present the sample selection and characteristics of the ALMA observations, and showcase some of the key results enabled by the combination of spatially-matched stellar populations and gas measurements. Considering the global (aperture-matched) stellar mass, molecular gas mass, and star formation rate of the sample, we find that the sSFR depends on both the star formation efficiency (SFE) and the molecular gas fraction ($f_{\rm H_{2}}$), although the correlation with the latter is slightly weaker. Furthermore, the dependence of sSFR on the molecular gas content (SFE or $f_{\rm H_{2}}$) is stronger than that on either the atomic gas fraction or the molecular-to-atomic gas fraction, albeit with the small HI sample size. On kpc scales, the variations in both SFE and $f_{\rm H_{2}}$ within individual galaxies can be as large as 1-2 dex thereby demonstrating that the availability of spatially-resolved observations is essential to understand the details of both star formation and quenching processes.STFC ER

Measurement invariance of the sexual orientation microaggression inventory across LGB males and females in Taiwan: bifactor structure fits the best

The present study examined the factor structure and concurrent validity of the traditional Chinese version of the Sexual Orientation Microaggression Inventory (SOMI) among lesbian, gay, and bisexual (LGB) individuals in Taiwan. In total, 1000 self-identified LGB individuals completed the SOMI, HIV and Homosexuality Related Stigma Scale (HHRSS), and Acceptance and Action Questionnaire-II (AAQ). Different factor structures (including one-factor, four-factor, bifactor, and higher-order factor structures) were evaluated using confirmatory factor analysis. The bifactor structure significantly outperformed all others on the SOMI. The bifactor structure with one general factor and four trait factors was found to be measurement invariant across biological sex with satisfactory fit indices. The SOMI general factor was significantly associated with HHRSS-Homosexu-ality score and AAQ score. The findings indicate that the SOMI is a psychometrically sound instrument for Taiwan sexual minority groups. More specifically, SOMI can be used to accurately assess microaggression among LGB individuals. The measure on microaggression may also provide insights for healthcare providers about LGB individuals' sexuality-related stigma. Moreover, healthcare providers and relevant stakeholders can use the SOMI to understand how LGB individuals perceive and feel microaggression

Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans

The mouse is one of the most widely used animal models to study neuromuscular diseases and test new therapeutic strategies. However, findings from successful pre-clinical studies using mouse models frequently fail to translate to humans due to various factors. Differences in muscle function between the two species could be crucial but often have been overlooked. The purpose of this study was to evaluate and compare muscle excursions in walking between mice and humans