5,818 research outputs found
Preventing Isolated Perioperative Reintubation: Who is at highest risk?
Objectives:
1. We aim to characterize IPR nationally through a retrospective review of the National Surgical Quality Improvement Program participant user file (NSQIP PUF).
2.Identify risk factors for IPR including analysis of procedure type and preoperative characteristics.https://jdc.jefferson.edu/patientsafetyposters/1041/thumbnail.jp
Quantifying Patient Reported and Documented Compliance with Adjuncts to Venous Thromboembolism Prophylaxis
Objectives:
1. Measure patient compliance with pharmacologic, mechanical and ambulatory prophylactic measures.
2. Evaluate for agreement between nursing documentation and patient reported compliance with mechanical and ambulatory prophylactic measures.https://jdc.jefferson.edu/patientsafetyposters/1042/thumbnail.jp
How good are we at determining risk? Quantifying the accuracy of clinician determined risk for VTE prophylaxis
Objectives:
Create and validate a simple tool for concurrent audits of risk stratification, compliance and documentation
Evaluate accuracy of clinician risk stratification and prophylatic ordering practice compared with a standardized Caprini RAM across different assigned risk categories
Provide recommendations for EPIC VTE Prophylaxis CDS Developmenthttps://jdc.jefferson.edu/patientsafetyposters/1050/thumbnail.jp
On Glauber modes in Soft-Collinear Effective Theory
Gluon interactions involving spectator partons in collisions at hadronic
machines are investigated. We find a class of examples in which a mode, called
Glauber gluons, must be introduced to the effective theory for consistency.Comment: 19 pages, three figures. Uses JHEP3.cl
Non-global Structure of the O({\alpha}_s^2) Dijet Soft Function
High energy scattering processes involving jets generically involve matrix
elements of light- like Wilson lines, known as soft functions. These describe
the structure of soft contributions to observables and encode color and
kinematic correlations between jets. We compute the dijet soft function to
O({\alpha}_s^2) as a function of the two jet invariant masses, focusing on
terms not determined by its renormalization group evolution that have a
non-separable dependence on these masses. Our results include non-global single
and double logarithms, and analytic results for the full set of non-logarithmic
contributions as well. Using a recent result for the thrust constant, we
present the complete O({\alpha}_s^2) soft function for dijet production in both
position and momentum space.Comment: 55 pages, 8 figures. v2: extended discussion of double logs in the
hard regime. v3: minor typos corrected, version published in JHEP. v4: typos
in Eq. (3.33), (3.39), (3.43) corrected; this does not affect the main
result, numerical results, or conclusion
Efficacy and safety of Vilobelimab (IFX-1), a novel monoclonal anti-C5a antibody, in patients with early severe sepsis or septic shock — a randomized, placebo-controlled, double-blind, multicenter, phase IIa Trial (SCIENS Study)
IMPORTANCE:. Anaphylatoxin C5a, a proinflammatory complement split product, plays a central role in mediating organ dysfunction.
OBJECTIVES:. This phase II clinical trial was conducted to study safety, tolerability, pharmacokinetics, and pharmacodynamics of vilobelimab, a recombinant monoclonal antibody against C5a, in patients with severe sepsis or septic shock.
DESIGN:. Multicenter, randomized, and placebo-controlled study.
SETTING AND PARTICIPANTS:. Eleven multidisciplinary ICUs across Germany. Adult patients with severe sepsis or septic shock and with early onset of infection-associated organ dysfunction.
MAIN OUTCOMES AND MEASURES:. Patients were randomly assigned in a ratio of 2:1 to three subsequent dosing cohorts for IV vilobelimab or placebo receiving either 2 × 2 mg/kg (0 and 12 hr), 2 × 4 mg/kg (0 and 24 hr), and 3 × 4 mg/kg (0, 24, and 72 hr). Co-primary endpoints were pharmacodynamics (assessed by C5a concentrations), pharmacokinetics (assessed by vilobelimab concentrations), and safety of vilobelimab. Preliminary efficacy was evaluated by secondary objectives.
RESULTS:. Seventy-two patients were randomized (16 patients for each vilobelimab dosing cohort and eight patients for each placebo dosing cohort). Vilobelimab application was associated with dosing dependent decrease in C5a compared with baseline (p < 0.001). Duration of C5a decrease increased with more frequent dosing. Membrane attack complex lysis capacity measured by 50% hemolytic complement was not affected. Vilobelimab was well tolerated with similar safety findings in all dose cohorts. No vilobelimab-specific adverse events emerged. For vilobelimab-treated patients, investigators attributed less treatment-emergent adverse events as related compared with placebo. Dosing cohorts 2 and 3 had the highest ICU-free and ventilator-free days. There was no difference in mortality, vasopressor-free days, or renal replacement therapy-free days between the groups.
CONCLUSIONS AND RELEVANCE:. Administration of vilobelimab in patients with severe sepsis and septic shock selectively neutralizes C5a in a dose-dependent manner without blocking formation of the membrane attack complex and without resulting in detected safety issues. The data warrant further investigation of C5a inhibition in sepsis
IFN-γ Attenuates Eosinophilic Inflammation but Is Not Essential for Protection against RSV-Enhanced Asthmatic Comorbidity in Adult Mice
The susceptibility to respiratory syncytial virus (RSV) infection in early life has been associated with a deficient T-helper cell type 1 (Th1) response. Conversely, healthy adults generally do not exhibit severe illness from RSV infection. In the current study, we investigated whether Th1 cytokine IFN-γ is essential for protection against RSV and RSV-associated comorbidities in adult mice. We found that, distinct from influenza virus, prior RSV infection does not induce significant IFN-γ production and susceptibility to secondary Streptococcus pneumoniae infection in adult wild-type (WT) mice. In ovalbumin (OVA)-induced asthmatic mice, RSV super-infection increases airway neutrophil recruitment and inflammatory lung damage but has no significant effect on OVA-induced eosinophilia. Compared with WT controls, RSV infection of asthmatic Ifng-/- mice results in increased airway eosinophil accumulation. However, a comparable increase in eosinophilia was detected in house dust mite (HDM)-induced asthmatic Ifng-/- mice in the absence of RSV infection. Furthermore, neither WT nor Ifng-/- mice exhibit apparent eosinophil infiltration during RSV infection alone. Together, these findings indicate that, despite its critical role in limiting eosinophilic inflammation during asthma, IFN-γ is not essential for protection against RSV-induced exacerbation of asthmatic inflammation in adult mice
The Quark Beam Function at NNLL
In hard collisions at a hadron collider the most appropriate description of
the initial state depends on what is measured in the final state. Parton
distribution functions (PDFs) evolved to the hard collision scale Q are
appropriate for inclusive observables, but not for measurements with a specific
number of hard jets, leptons, and photons. Here the incoming protons are probed
and lose their identity to an incoming jet at a scale \mu_B << Q, and the
initial state is described by universal beam functions. We discuss the
field-theoretic treatment of beam functions, and show that the beam function
has the same RG evolution as the jet function to all orders in perturbation
theory. In contrast to PDF evolution, the beam function evolution does not mix
quarks and gluons and changes the virtuality of the colliding parton at fixed
momentum fraction. At \mu_B, the incoming jet can be described perturbatively,
and we give a detailed derivation of the one-loop matching of the quark beam
function onto quark and gluon PDFs. We compute the associated NLO Wilson
coefficients and explicitly verify the cancellation of IR singularities. As an
application, we give an expression for the next-to-next-to-leading logarithmic
order (NNLL) resummed Drell-Yan beam thrust cross section.Comment: 54 pages, 9 figures; v2: notation simplified in a few places, typos
fixed; v3: journal versio
Resummation of heavy jet mass and comparison to LEP data
The heavy jet mass distribution in e+e- collisions is computed to
next-to-next-to-next-to leading logarithmic (NNNLL) and next-to-next-to leading
fixed order accuracy (NNLO). The singular terms predicted from the resummed
distribution are confirmed by the fixed order distributions allowing a precise
extraction of the unknown soft function coefficients. A number of quantitative
and qualitative comparisons of heavy jet mass and the related thrust
distribution are made. From fitting to ALEPH data, a value of alpha_s is
extracted, alpha_s(m_Z)=0.1220 +/- 0.0031, which is larger than, but not in
conflict with, the corresponding value for thrust. A weighted average of the
two produces alpha_s(m_Z) = 0.1193 +/- 0.0027, consistent with the world
average. A study of the non-perturbative corrections shows that the flat
direction observed for thrust between alpha_s and a simple non-perturbative
shape parameter is not lifted in combining with heavy jet mass. The Monte Carlo
treatment of hadronization gives qualitatively different results for thrust and
heavy jet mass, and we conclude that it cannot be trusted to add power
corrections to the event shape distributions at this accuracy. Whether a more
sophisticated effective field theory approach to power corrections can
reconcile the thrust and heavy jet mass distributions remains an open question.Comment: 33 pages, 14 figures. v2 added effect of lower numerical cutoff with
improved extraction of the soft function constants; power correction
discussion clarified. v3 small typos correcte
Direct photon production with effective field theory
The production of hard photons in hadronic collisions is studied using
Soft-Collinear Effective Theory (SCET). This is the first application of SCET
to a physical, observable cross section involving energetic partons in more
than two directions. A factorization formula is derived which involves a
non-trivial interplay of the angular dependence in the hard and soft functions,
both quark and gluon jet functions, and multiple partonic channels. The
relevant hard, jet and soft functions are computed to one loop and their
anomalous dimensions are determined to three loops. The final resummed
inclusive direct photon distribution is valid to next-to-next-to-leading
logarithmic order (NNLL), one order beyond previous work. The result is
improved by including non-logarithmic terms and photon isolation cuts through
matching, and compared to Tevatron data and to fixed order results at the
Tevatron and the LHC. The resummed cross section has a significantly smaller
theoretical uncertainty than the next-to-leading fixed-order result,
particularly at high transverse momentum.Comment: 42 pages, 9 figures; v2: references added, minor changes; v3: typos;
v4: typos, corrections in (16), (47), (72
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