9 research outputs found
A Combinatorial Kin Discrimination System in Bacillus subtilis
- Author
- Abrudan
- Allenby
- Alteri
- Anderson
- Baptista
- Barbara Kraigher
- Benabentos
- Bensaci
- Budding
- Butcher
- Cohan
- Crozier
- Darling
- Dienes
- Dimitriu
- Durrett
- Earl
- Espinosa
- Hawlena
- Holberger
- Ines Mandic-Mulec
- Jansen
- Kearns
- Kiley
- Kobayashi
- Koskiniemi
- Lyons
- Mc Ginty
- Mijakovic
- Neuhaus
- Nicholas A. Lyons
- Pathak
- Polonca Stefanic
- Queller
- Rendueles
- Riley
- Roberto Kolter
- Ruhe
- Russell
- Salzberg
- Senior
- Smith
- Smukalla
- Soldo
- Srivatsan
- Stefanic
- Stefanic
- Stein
- Strassmann
- Traxler
- Vlamakis
- Vos
- Wecke
- Wenren
- Zeigler
- Zeigler
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Correlation of depositional patterns in the Ness Formation, Oseberg area
- Author
- A Hurst
- A Johnson
- A Jourdan
- AC Morton
- AD Cohen
- AE Ryseth
- BR Turner
- CB Land
- CC Parry
- CJ Percival
- CR Fielding
- CR Fielding
- CR Fielding
- DJ Cant
- E Graue
- E Oomkens
- E Strasburger
- EA Fitzpatrick
- FG Ethridge
- FM Broadhurst
- G Eynon
- GM Ashley
- HD Johnson
- JC Ferm
- JC Horne
- JD Collinson
- JD Collinson
- JM Bowen
- JR Staub
- JRL Allen
- JS Bridge
- JS Bridge
- JS Bridge
- M Taylor
- MC Budding
- ME Badley
- ME Badley
- MH Rider
- MJ Kraus
- P Buurman
- PD Guion
- PF Friend
- PJ McCabe
- R Matsumoto
- RG Walker
- RM Flores
- S Brown
- SE Livera
- T Elliott
- TA Ryer
- TA Ryer
- TA Ryer
- TM Bown
- W Nemec
- W Schwarzacher
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study
Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth
- Author
- A OâSullivan
- AC Lundell
- AD Kostic
- AE Budding
- AN Ardissone
- B Abdulkadir
- B Brooks
- B van den Bogert
- BE Cormack
- CJ Stewart
- CL Bevins
- CM Bassis
- CT Brown
- D Gevers
- D McDonald
- DB DiGiulio
- DW Fadrosh
- EC Gritz
- F Backhed
- F Yao
- FH Heida
- G Sharon
- H Renz
- I Holmes
- I Sharon
- J Neu
- J Santos
- JD Horbar
- JG Caporaso
- JL Slaughter
- JL Slaughter
- JN Paulson
- K Aagaard
- KE Gregory
- L Putignani
- LV Blanton
- M De Curtis
- M Manco
- MC Collado
- MG Langille
- MJ Butel
- MS Cilieborg
- MW Groer
- N Bekkali
- N Segata
- NB Rutten
- PE Larsen
- PJ Turnbaugh
- PS La Rosa
- Q Wang
- R McGill
- RC Edgar
- RW Gupta
- S Arboleya
- SE Pryde
- SM Duty
- SP Claus
- T Yatsunenko
- TJ Cole
- TR Fenton
- TR Fenton
- TZ DeSantis
- V Tremaroli
- XC Morgan
- Z Hochberg
- Z Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Diagnostic Tests to Support Late-Stage Control Programs for Schistosomiasis and Soil-Transmitted Helminthiases
- Author
- A Rosser
- AE Budding
- AL Bustinduy
- AM Deelder
- AM Deelder
- AV Easton
- AW Solomon
- B Gryseels
- B Nikolay
- B Tarp
- Brandon T. Leader
- C Cutillas
- C Wang
- CA Gordon
- CJ Standley
- D Mabey
- D Wichmann
- DG Colley
- DG Colley
- E Tjon Kon Fat
- EA Ochodo
- FA Jonker
- GH Liu
- GJ van Dam
- GJ van Dam
- GJ van Dam
- GJ van Dam
- GJ van Dam
- GJ van Dam
- GJ van Dam
- H Smith
- Helen L. Storey
- HL Guyatt
- HL Shane
- J Bethony
- J Liu
- J Mans
- J Xu
- Jason L. Cantera
- JJ Verweij
- JM de Gruijter
- JP Webster
- JR Monti
- JR Stothard
- JR Stothard
- JR Stothard
- JT Coulibaly
- Justin V. Remais
- K Polman
- Kenneth R. Hawkins
- KG Weerakoon
- KJ Moendeg
- L Cnops
- LA Pontes
- LI Gomes
- LI Gomes
- LI Gomes
- LL van
- LM Oliveira
- M Adriko
- M Basuni
- M Legesse
- M Sato
- MC Carvalho do Espirito-Santo
- MC Espirito-Santo
- MJ Enk
- N Kato-Hayashi
- N Katz
- N Lodh
- N Sandoval
- P Fernandez-Soto
- PL Corstjens
- PL Corstjens
- R Bergquist
- RA Ashton
- RA Kane
- RB Gasser
- RD Bungiro Jr.
- RJ ten Hove
- RO Cimino
- S Knopp
- S Knopp
- S Llewellyn
- T Lier
- T Lier
- Tala de los Santos
- WR Alan
- YC Cai
- Z Demerdash
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Technetium-99m Sestamibi Single Photon Emission Computed Tomography Findings Correlated With P-glycoprotein Expression, Encoded by the Multidrug Resistance Gene-1 Messenger Ribonucleic Acid, in Intracranial Meningiomas
- Author
- Andrews DW Das R, Kim S, Zhang J, Curtis M
- Baillet G Albuquerque L, Chen Q, Poisson M, Delattre JY
- Black KL Hawkins RA, Kim KT, Becker DP, Lerner C, Marciano D
- Chamberlain MC
- Crane P Laliberte R, Heminway S
- Elligsen JD Thompson JE, Frey HE, Kruv J
- Hao D Huan SD, Stewart DJ, Segal RJ, Yau JC
- Hendrikse NH Franssen EJF, van der Graaf WTA, Vaalburg W, de Vries EGE
- Kasarow LB Friedman H
- Mason WP Gentili F, Macdonald DR, Hariharans S, Cruz CR, Abrey LE
- Muhr C Gudjonsson O, Lilja A, Hartman M, Zhang ZJ, Langstrom B
- Nagamachi S Jinnouchi S, Nabeshima K, Nishii R, Flores L II, Kodama T, Kawai K, Tamura S, Yokogami K, Samejima T, Wakisaka S
- O'Tuama LA Treves ST, Larar JN, Packard AB, Kwan AJ, Barnes PD, Scott RM, Black PM, Madsen JR, Goumnerova LC, Sallan SE, Tarbell NJ
- Piwinca-Worms D Chiu ML, Budding M, Kronauge JF, Kramer RA, Croop JM
- Rosenthal MA Ashley DL, Cher L
- Sasaki M Kuwabara Y, Yoshida T, Nakagawa M, Fukumura T, Mihara F, Morioka T, Fukui M, Masuda K
- Sawada T Kato Y, Sakayori N, Takekawa Y, Kobayashi M
- Schrell UM Rittig MG, Anders M, Kiesewetter F, Marschalek R, Koch UH, Fahlbusch R
- SHIBATA Y
- Soler C Beauchesne P, Maatougui K, Schmitt T, Barral FG, Michel D, Dubois F, Brunon J
- Spiegl-Kreinecker S Buchroithner J, Elbling L, Steiner E, Wurm G, Bodenteich A, Fischer J, Micksche M, Berger W
- Taki S Kakuda K, Kakuma K, Kobayashi K, Ohashi M, Ito S, Yokoyama M, Annen Y, Tonami N
- Tews DS Fleissner C, Tiziani B, Gaumann AK
- YAMAMOTO Y
- Yokogami K Kawano H, Moriyama T, Uehara H, Sameshima T, Oku T, Goya T, Wakisaka S, Nagamachi S, Jinnouchi S, Tamura S
- Publication venue
- 'Japan Neurosurgical Society'
- Publication date
- 01/01/2003
- Field of study
Predictability of properties of a fractured geothermal reservoir: the opportunities and limitations of an outcrop analogue study
- Author
- A Franco
- A Vollbrecht
- AD Miall
- C MĂŒller
- CA Barton
- CA Barton
- CE Fairhurst
- CK Wentworth
- D Pribnow
- D Reyer
- DE Dunn
- DL Sahagian
- DR Faulkner
- DR Faulkner
- DT Snow
- DT Snow
- E Backhaus
- E Jolie
- EF McBride
- FM Chester
- G Marsily De
- G Richter-Bernburg
- GH Eisbacher
- GP Kruseman
- GR Pickett
- H Sibson
- I Rupf
- I Stober
- J Bear
- J Hull
- J Meixner
- JA Howell
- JH Illies
- JH Illies
- JH Illies
- JM Larroque
- JP Brun
- JP Evans
- JS Caine
- K Hestir
- K Steingötter
- KJ Heffer
- KJ Keogh
- M Krumbholz
- M Krumbholz
- M Ramm
- M Schwarz
- M Szurlies
- MC Budding
- ME Schumacher
- MR Gross
- N Clauer
- N Molenaar
- NE Odling
- NJC Farrell
- PA Domenico
- PA Witherspoon
- PA Ziegler
- PA Ziegler
- PA Ziegler
- PA Ziegler
- PJR Fitch
- PM Adler
- R Chesnaux
- R Marrett
- R Schellschmidt
- RA Freeze
- RD Terzaghi
- RH Lander
- RH Lander
- RL Carlson
- RM Holt
- S Bourquin
- S Feist-Burkhardt
- S Meier
- S Morad
- SE Berg
- SE Laubach
- SE Laubach
- SE Laubach
- SE Laubach
- SE Schulz
- SL Philipp
- SM Luthi
- SN Ehrenberg
- T Agemar
- T Golf-Racht van
- T Plenefisch
- T Villemin
- V Palchik
- V Palchik
- VF Bense
- W Narr
- ZK Shipton
- ZK Shipton
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Role of priority effects in the early-life assembly of the gut microbiota
- Author
- A Conde-Agudelo
- A Folkesson
- A Lavelle
- A Marcobal
- A Marcobal
- AE Budding
- AL Hecht
- AL Thompson
- AN Ardissone
- AP Lauder
- AR Burns
- AR Erickson
- B Brooks
- C Martinez
- C Milani
- C Palmer
- CA Merrifield
- CF Steiner
- CG Buffie
- CM Tucker
- CS Han
- D Gevers
- DA Sela
- Daniel Sprockett
- David A. Relman
- DB DiGiulio
- DB DiGiulio
- DE Williams
- DH Taft
- DJ Lemas
- DM Chu
- DM Chu
- E Jiménez
- E Ottosson
- EJ de Muinck
- EK Costello
- EK Costello
- EK Costello
- EM Brown
- EW Rogier
- F BĂ€ckhed
- FM Smaill
- FS Martins
- G Biasucci
- G Devevey
- G SolĂs
- GL Darmstadt
- H Makino
- H Seedorf
- HE Jakobsson
- HS Deshmukh
- I Cho
- I Sharon
- J Barroso-Batista
- J Fukuyama
- J Gray
- J Penders
- JC Thompson
- JD Planer
- JE Koenig
- JH Tabibian
- JR Donowitz
- K Aagaard
- K AlFaleh
- K Costeloe
- KD Hendricks-Muñoz
- KM Hunt
- KM McKenna
- KM Ng
- L Abusleme
- L Bode
- L Dethlefsen
- L Moles
- LH Lam
- LJ Funkhouser
- LM Cox
- M Gomez de Aguero
- M Hornef
- M Nermes
- M Vellend
- M Vellend
- M Vellend
- M Yassour
- MC Collado
- ME Kirst
- MF Laursen
- MG Dominguez-Bello
- MG Dominguez-Bello
- MJ Blaser
- MJ Gosalbes
- MM Grönlund
- MN Huda
- MR Olm
- NA Bokulich
- NM Koropatkin
- P Khodayar-Pardo
- P Panigrahi
- PH Warren
- PJ Morin
- PJ Turnbaugh
- PJ Turnbaugh
- R Cabrera-Rubio
- R Kort
- R Malakar
- R MartĂn
- R Nagata
- RA Koeth
- RL Marvig
- RL Vannette
- S Arboleya
- S Nayfach
- S Schwarz
- S Singh
- S Subramanian
- S Zeissig
- SJ Song
- SM Lee
- SP Hubbell
- SS Witkin
- T Fukami
- T Gensollen
- T Vatanen
- T Yatsunenko
- Tadashi Fukami
- TL Ward
- TM Wassenaar
- UK Choudhry
- V Doublet
- V MartĂn
- V Zanardo
- VK Ridaura
- W Jiang
- X Didelot
- Y Fardini
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Merging mythology and morphology: the multifaceted lifestyle of Proteus mirabilis
- Author
- A Dedeic-Ljubovic
- A Dufour
- A Lima
- A Ronald
- AA Miles
- AE Budding
- AM Jansen
- AM Jansen
- BD Jones
- BD Jones
- BR Hart
- BV Jones
- BW Senior
- BW Senior
- C Allison
- C Allison
- C Coker
- C Coker
- CA Murphy
- CA Poore
- Chelsie E. Armbruster
- CM Kunin
- CM Kunin
- CM O'Hara
- D Stankowska
- D Stankowska
- D Stickler
- D Stickler
- DE Johnson
- DE Yakubu
- DJ Stickler
- DJ Stickler
- DL MacIntyre
- DP Griffith
- E Vinogradov
- EB Nicholson
- EB Nicholson
- EL Flannery
- EL Flannery
- FK Bahrani
- FK Bahrani
- G Hauser
- G Massad
- G Massad
- G Rahav
- G Sturgill
- GJ Williams
- GR Chippendale
- GR Nielubowicz
- GR Nielubowicz
- H Mobley
- H Zhao
- H Zhao
- H Zhao
- Harry L. T. Mobley
- HD Wazait
- HL Mobley
- HL Mobley
- IK Tan
- JA Snyder
- JD Dattelbaum
- JFM Hoeniger
- JJ Wenner
- JK Hatt
- JM Calvo
- JP Armitage
- K Cusick
- KA Gibbs
- KA Gibbs
- KE Walker
- KG Swihart
- KK Lee
- KM Clemmer
- KM Clemmer
- L Dienes
- LE Nicolle
- LG Stevenson
- LS Burall
- M Boyer
- MC Lane
- MD Island
- MM Pearson
- MM Pearson
- MM Pearson
- MM Pearson
- MM Pearson
- MTG Holden
- N Majdalani
- N Sabbuba
- NA Sabbuba
- NJ Bainton
- NS Morris
- NS Morris
- NS Morris
- P Alamuri
- P Alamuri
- P Alamuri
- P Klemm
- P Scavone
- P Scavone
- P Zunino
- P Zunino
- P Zunino
- P Zunino
- PG Peerbooms
- PN Rather
- R Belas
- R Belas
- R Belas
- R Belas
- R Pellegrino
- R Schneider
- RB Breitenbucher
- RB Mathoera
- RK Latta
- RM Morgenstein
- RM Morgenstein
- S Gaisser
- S Mathur
- S Wang
- S-J Liaw
- S-J Liaw
- S-S Jiang
- SD Himpsl
- SD Himpsl
- SE D'Orazio
- SE D'Orazio
- SM Jacobsen
- SM Jones
- SM Macleod
- SPD Rocha
- T Sareneva
- TM Hooton
- VJ Thomas
- W-B Wang
- X Li
- X Li
- X Li
- X Li
- X Li
- Y Siegman-Igra
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study
- Author
- Abada S
- Abbas Syed R
- Abbas JD
- Abdalla M
- Abdel-Khaleq S
- Abdelrahim ASA
- Abdelrazek M
- Abdelrazik Y
- Abdi M
- Abdolrazaghi S
- Abdul-Fattah S
- Abdulla S
- Abdullah M
- Abi Aoun R
- Abid S
- Abigail S
- Abou El Ela Bourquin B
- Abousamra M
- Adabavazeh B
- Adams J
- Adams M
- Adams N
- Adcock A
- Adebambo D
- Adeboyejo O
- Adeeko ES
- Adelekan K
- Adelowo T
- Adeniken E
- Adeoye A
- Adeusi L
- Afsheen N
- Agarwal A
- Agarwal G
- Agarwal N
- Agbinya N
- Aghanenu O
- Agiotakis S
- Aguirrezabala Armbruster B
- Ahari D
- Ahmad Fuad MF
- Ahmad MA
- Ahmad NA
- Ahmadi H
- Ahmed Osman A
- Ahmed A
- Ahmed I
- Ahmed J
- Ahmed M
- Ahmed O
- Ahmed S
- Ahmed SK
- Ahmed W
- Ainsworth J
- Ainsworth K
- Aitken S
- Ajdarpasic D
- Ajekigbe F
- Akbar Z
- Akhbari M
- Akintunde A
- Akinyemi J
- Akmal A
- Akmal K
- Akram B
- Al Bahri T
- Al Bakry M
- Al Dabbagh A
- Al Rawi M
- Al Sadek Y
- Al-Hamid Z
- Al-Khafaji M
- Alam F
- Alattas A
- Alawattegama LH
- Alberts J
- Alfadhel S
- Alhwaishel K
- Ali Butt S
- Ali A
- Ali K
- Ali M
- Ali N
- Ali S
- Alim L
- Alkandari B
- Alkoot M
- Allan D
- Allan J
- Allen K
- Allen R
- Allin D
- Almoosawy SA
- Alom J
- Alsaady A
- Alsadoun L
- Alsusa H
- Alves do Canto Brum H
- Alves D
- Aly R
- Alyacoubi S
- Amakye NY
- Amarnath T
- Amin A
- Amin M
- Amini B
- Anandampillai R
- Anarfi S
- Anderson E
- Anderson P
- Anderton J
- Andrew F
- Anjum Z
- Ansar Z
- Anthony Wilkinson J
- Antypas A
- Anuar A
- Apata A
- Appanna T
- Appleton B
- Appleyard T
- Arain Z
- Aranha M
- Arnold A
- Arnold C
- Arora E
- Arrayeh A
- Arshad M
- Arshad SR
- Arthur-Quarm S
- Arumugam V
- Arwi G
- Ashai S
- Asharaf H
- Ashaye A
- Ashcroft-Quinn S
- Ashdown T
- Ashman M
- Ashok A
- Ashwell W
- Ashworth I
- Asif A
- Asvandi S
- Atherton R
- Atiyah A
- Atkins W
- Aung E
- Aung YY
- Austin T
- Ayandokun P
- Ayub H
- Azam R
- Azam Z
- Azeez Z
- Azizan N
- Azizi S
- Azlan A
- Azouaghe O
- Bachelet B
- Bacigalupo V
- Bacon H
- Badminton R
- Badran A
- Bahl S
- Bailey A
- Bain J
- Bajaj M
- Bajaj S
- Bajaj V
- Baker C
- Baker D
- Baker J
- Baker O
- Bakina C
- Balakumar V
- Balasubramanian A
- Balasubramanian N
- Bald A
- Balfour J
- Ball M
- Bandyopadhyay D
- Bandyopadhyay S
- Bangi S
- Bani W
- Bannister J
- Barabas M
- Baraza W
- Barciela C
- Bardon A
- Barham E
- Barnes R
- Barrett G
- Barrington J
- Barrington M
- Barry I
- Barry J
- Barry K
- Bartlett M
- Barton O
- Bashiti H
- Basi S
- Baskaran R
- Bassett E
- Batchelor C
- Batchelor-Parry H
- Bawa G
- Bawa JH
- Beattie M
- Beck C
- Bee F
- Beg R
- Belais F
- Belk LH
- Bellam S
- Ben-Arzi H
- Bennett T
- Bennewith R
- Berry A
- Bettoli G
- Bevis R
- Bhachoo H
- Bhadra K
- Bhandari A
- Bhangu A
- Bhardwaj R
- Bharwada Y
- Bhat A
- Bhate R
- Bhatia P
- Bhatia S
- Bhattarai S
- Bhatti M
- Bhatti S
- Bhavra K
- Bhoombla N
- Bhudia R
- Bhullar D
- Bibi F
- Biddles D
- Bilal A
- Billson E
- Bilolikar A
- Bird R
- Birnie C
- Bishop A
- Bisson E
- Bix E
- Bloom I
- Blott N
- Boaden L
- Boggon E
- Bogie E
- Bojanic C
- Bommireddy L
- Bonte A
- Borakati A
- Bosley N
- Botsa E
- Bottomley J
- Bourke E
- Bourne K
- Bowen K
- Bowes A
- Bowley D
- Boyle C
- Bradley J
- Bradshaw E
- Brady R
- Braganza J
- Bratsos S
- Brazier B
- Brazkiewicz M
- Breathnach C
- Brenac S
- Brew A
- Bridges I
- Broad G
- Broekhuizen A
- Brookes T
- Brothwood D
- Brousse de Gersigny J
- Browlee O
- Brown A
- Brown C
- Brown E
- Brown G
- Brown L
- Brown R
- Brown S
- Browne R
- Bruce D
- Bryan A
- Bryans K
- Bucknall T
- Budd W
- Budding J
- Bunni J
- Burke D
- Burns F
- Burns J
- Burrell K
- Burt G
- Burt J
- Burtle D
- Burton L
- Burton M
- Burway S
- Buxton-Hopley R
- Byrne M
- Cahya E
- Caldwell S
- Cambridge WA
- Cameron F
- Campbell A
- Campbell B
- Cann J
- Carberry E
- Carey C
- Carpenter H
- Carr W
- Carrick M
- Carroll L
- Carroll M
- Casey A
- Cavanagh S
- Chadda KR
- Chadwick T
- Chalkley M
- Chamberlain G
- Champion A
- Chan C
- Chan LH
- Chan SMZ
- Chan XHF
- Chand CP
- Chandegra A
- Chander B
- Chandrasekaran J
- Chandratreya N
- Chang C
- Chaora T
- Chapman D
- Chapman S
- Chapman T
- Chapple K
- Charalambous M
- Chatha S
- Chau CYC
- Chaudhari S
- Chawla S
- Cheah E
- Chee J
- Cheekoty P
- Cheema J
- Chellapuri A
- Chen JY
- Cheng T
- Chennupati R
- Cheong J
- Cherry C
- Cheung A
- Cheung J
- Chew D
- Chew SJHL
- Chia D
- Chia WL
- Chikomba L
- Chinta SH
- Chiong J
- Chittoor Satish NN
- Chiu C
- Chlubek M
- Chmielewski G
- Cho SH
- Choa G
- Choi NY
- Chong A
- Chong C
- Chong T
- Chong V
- Choo LY
- Choo SY
- Chopra P
- Chou WK
- Choudhry A
- Choudhry H
- Chow J
- Chow R
- Chow YW
- Chowdhury A
- Chowdhury S
- Chowdhury T
- Chrisp B
- Christie I
- Christou A
- Chu J
- Chu K
- Chu TSM
- Chu YYA
- Chung I
- Chung S
- Cinnamond A
- Cirelli C
- Clark A
- Clark F
- Clark G
- Clark L
- Clarke G
- Clayton B
- Clayton S
- Cleaver J
- Clement NS
- Clements B
- Clements JM
- Cloney M
- Coates S
- Cockroft A
- Coldwell C
- Coleman O
- Coleman S
- Colman J
- Colterjohn N
- Common J
- Common T
- Compton M
- Connachan R
- Connell B
- Constantinides M
- Conti I
- Cook A
- Cook E
- Cookey-Bresi R
- Coombe-Jones M
- Coombs A
- Cooper Drake B
- Cooper L
- Cope P
- Cope S
- Copeland L
- Cornwall H
- Corrin E
- Costa I
- Coulson A
- Coulthurst J
- Court EL
- Covell G
- Coyle J
- Creagh-Brown B
- Creissen A
- Cresswell B
- Cripps P
- Crisp E
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2022
- Field of study
Background Stratifying risk of postoperative pulmonary complications after major abdominal surgery allows clinicians to modify risk through targeted interventions and enhanced monitoring. In this study, we aimed to identify and validate prognostic models against a new consensus definition of postoperative pulmonary complications. Methods We did a systematic review and international external validation cohort study. The systematic review was done in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched MEDLINE and Embase on March 1, 2020, for articles published in English that reported on risk prediction models for postoperative pulmonary complications following abdominal surgery. External validation of existing models was done within a prospective international cohort study of adult patients (â„18 years) undergoing major abdominal surgery. Data were collected between Jan 1, 2019, and April 30, 2019, in the UK, Ireland, and Australia. Discriminative ability and prognostic accuracy summary statistics were compared between models for the 30-day postoperative pulmonary complication rate as defined by the Standardised Endpoints in Perioperative Medicine Core Outcome Measures in Perioperative and Anaesthetic Care (StEP-COMPAC). Model performance was compared using the area under the receiver operating characteristic curve (AUROCC). Findings In total, we identified 2903 records from our literature search; of which, 2514 (86·6%) unique records were screened, 121 (4·8%) of 2514 full texts were assessed for eligibility, and 29 unique prognostic models were identified. Nine (31·0%) of 29 models had score development reported only, 19 (65·5%) had undergone internal validation, and only four (13·8%) had been externally validated. Data to validate six eligible models were collected in the international external validation cohort study. Data from 11â591 patients were available, with an overall postoperative pulmonary complication rate of 7·8% (n=903). None of the six models showed good discrimination (defined as AUROCC â„0·70) for identifying postoperative pulmonary complications, with the Assess Respiratory Risk in Surgical Patients in Catalonia score showing the best discrimination (AUROCC 0·700 [95% CI 0·683â0·717]). Interpretation In the pre-COVID-19 pandemic data, variability in the risk of pulmonary complications (StEP-COMPAC definition) following major abdominal surgery was poorly described by existing prognostication tools. To improve surgical safety during the COVID-19 pandemic recovery and beyond, novel risk stratification tools are required. Funding British Journal of Surgery Society