3,436 research outputs found
Characterising epithelial tissues using persistent entropy
In this paper, we apply persistent entropy, a novel topological statistic,
for characterization of images of epithelial tissues. We have found out that
persistent entropy is able to summarize topological and geometric information
encoded by \alpha-complexes and persistent homology. After using some
statistical tests, we can guarantee the existence of significant differences in
the studied tissues.Comment: 12 pages, 7 figures, 4 table
Stabilising touch interactions in cockpits, aerospace, and vibrating environments
© Springer International Publishing AG, part of Springer Nature 2018. Incorporating touch screen interaction into cockpit flight systems is increasingly gaining traction given its several potential advantages to design as well as usability to pilots. However, perturbations to the user input are prevalent in such environments due to vibrations, turbulence and high accelerations. This poses particular challenges for interacting with displays in the cockpit, for example, accidental activation during turbulence or high levels of distraction from the primary task of airplane control to accomplish selection tasks. On the other hand, predictive displays have emerged as a solution to minimize the effort as well as cognitive, visual and physical workload associated with using in-vehicle displays under perturbations, induced by road and driving conditions. This technology employs gesture tracking in 3D and potentially eye-gaze as well as other sensory data to substantially facilitate the acquisition (pointing and selection) of an interface component by predicting the item the user intents to select on the display, early in the movements towards the screen. A key aspect is utilising principled Bayesian modelling to incorporate and treat the present perturbation, thus, it is a software-based solution that showed promising results when applied to automotive applications. This paper explores the potential of applying this technology to applications in aerospace and vibrating environments in general and presents design recommendations for such an approach to enhance interactions accuracy as well as safety
Vanishing of phase coherence in underdoped Bi_2Sr_2CaCu_2O_8+d
Coherent time-domain spectroscopy is used to measure the screening and
dissipation of high-frequency electromagnetic fields in a set of underdoped
Bi_2Sr_2CaCu_2O_8+d thin films. The measurements provide direct evidence for a
phase-fluctuation driven transition from the superconductor to normal state,
with dynamics described well by the Berezinskii-Kosterlitz-Thouless theory of
vortex-pair unbinding.Comment: Nature, Vol. 398, 18 March 1999, pg. 221 4 pages with 4 included
figure
Dense active matter model of motion patterns in confluent cell monolayers
Epithelial cell monolayers show remarkable displacement and velocity
correlations over distances of ten or more cell sizes that are reminiscent of
supercooled liquids and active nematics. We show that many observed features
can be described within the framework of dense active matter, and argue that
persistent uncoordinated cell motility coupled to the collective elastic modes
of the cell sheet is sufficient to produce swirl-like correlations. We obtain
this result using both continuum active linear elasticity and a normal modes
formalism, and validate analytical predictions with numerical simulations of
two agent-based cell models, soft elastic particles and the self-propelled
Voronoi model together with in-vitro experiments of confluent corneal
epithelial cell sheets. Simulations and normal mode analysis perfectly match
when tissue-level reorganisation occurs on times longer than the persistence
time of cell motility. Our analytical model quantitatively matches measured
velocity correlation functions over more than a decade with a single fitting
parameter.Comment: updated version accepted for publication in Nat. Com
Strings in AdS_4 x CP^3: finite size spectrum vs. Bethe Ansatz
We compute the first curvature corrections to the spectrum of light-cone
gauge type IIA string theory that arise in the expansion of about a plane-wave limit. The resulting spectrum is shown to
match precisely, both in magnitude and degeneration that of the corresponding
solutions of the all-loop Gromov--Vieira Bethe Ansatz. The one-loop dispersion
relation correction is calculated for all the single oscillator states of the
theory, with the level matching condition lifted. It is shown to have all
logarithmic divergences cancelled and to leave only a finite exponentially
suppressed contribution, as shown earlier for light bosons. We argue that there
is no ambiguity in the choice of the regularization for the self-energy sum,
since the regularization applied is the only one preserving unitarity.
Interaction matrices in the full degenerate two-oscillator sector are
calculated and the spectrum of all two light magnon oscillators is completely
determined. The same finite-size corrections, at the order 1/J, where is
the length of the chain, in the two-magnon sector are calculated from the all
loop Bethe Ansatz. The corrections obtained by the two completely different
methods coincide up to the fourth order in . We
conjecture that the equivalence extends to all orders in and to
higher orders in 1/J.Comment: 32 pages. Published version; journal reference adde
Scattering of Giant Magnons in CP^3
We study classical scattering phase of CP^2 dyonic giant magnons in R_t x
CP^3. We construct two-soliton solutions explicitly by the dressing method.
Using these solutions, we compute the classical time delays for the scattering
of giant magnons, and compare them to boundstate S-matrix elements derived from
the conjectured AdS_4/CFT_3 S-matrix by Ahn and Nepomechie in the strong
coupling limit. Our result is consistent with the conjectured S-matrix. The
dyonic solutions play an essential role in revealing the polarization
dependence of scattering phase.Comment: 29 pages; v2: minor corrections; v3: minor corrections, references
added ; v4: minor corrections ; v5: minor corrections based on the published
versio
Verticalization of bacterial biofilms
Biofilms are communities of bacteria adhered to surfaces. Recently, biofilms
of rod-shaped bacteria were observed at single-cell resolution and shown to
develop from a disordered, two-dimensional layer of founder cells into a
three-dimensional structure with a vertically-aligned core. Here, we elucidate
the physical mechanism underpinning this transition using a combination of
agent-based and continuum modeling. We find that verticalization proceeds
through a series of localized mechanical instabilities on the cellular scale.
For short cells, these instabilities are primarily triggered by cell division,
whereas long cells are more likely to be peeled off the surface by nearby
vertical cells, creating an "inverse domino effect". The interplay between cell
growth and cell verticalization gives rise to an exotic mechanical state in
which the effective surface pressure becomes constant throughout the growing
core of the biofilm surface layer. This dynamical isobaricity determines the
expansion speed of a biofilm cluster and thereby governs how cells access the
third dimension. In particular, theory predicts that a longer average cell
length yields more rapidly expanding, flatter biofilms. We experimentally show
that such changes in biofilm development occur by exploiting chemicals that
modulate cell length.Comment: Main text 10 pages, 4 figures; Supplementary Information 35 pages, 15
figure
Numerical results for the exact spectrum of planar AdS4/CFT3
We compute the anomalous dimension for a short single-trace operator in
planar ABJM theory at intermediate coupling. This is done by solving
numerically the set of Thermodynamic Bethe Ansatz equations which are expected
to describe the exact spectrum of the theory. We implement a truncation method
which significantly reduces the number of integral equations to be solved and
improves numerical efficiency. Results are obtained for a range of 't Hooft
coupling lambda corresponding to , where h(lambda) is
the interpolating function of the AdS4/CFT3 Bethe equations.Comment: v3: corrected Acknowledgements section; v4: minor changes, published
version; v5: fixed typos in Eq. (3.9
Differential Effects of MYH9 and APOL1 Risk Variants on FRMD3 Association with Diabetic ESRD in African Americans
Single nucleotide polymorphisms (SNPs) in MYH9 and APOL1 on chromosome 22 (c22) are powerfully associated with non-diabetic end-stage renal disease (ESRD) in African Americans (AAs). Many AAs diagnosed with type 2 diabetic nephropathy (T2DN) have non-diabetic kidney disease, potentially masking detection of DN genes. Therefore, genome-wide association analyses were performed using the Affymetrix SNP Array 6.0 in 966 AA with T2DN and 1,032 non-diabetic, non-nephropathy (NDNN) controls, with and without adjustment for c22 nephropathy risk variants. No associations were seen between FRMD3 SNPs and T2DN before adjusting for c22 variants. However, logistic regression analysis revealed seven FRMD3 SNPs significantly interacting with MYH9—a finding replicated in 640 additional AA T2DN cases and 683 NDNN controls. Contrasting all 1,592 T2DN cases with all 1,671 NDNN controls, FRMD3 SNPs appeared to interact with the MYH9 E1 haplotype (e.g., rs942280 interaction p-value = 9.3E−7 additive; odds ratio [OR] 0.67). FRMD3 alleles were associated with increased risk of T2DN only in subjects lacking two MYH9 E1 risk haplotypes (rs942280 OR = 1.28), not in MYH9 E1 risk allele homozygotes (rs942280 OR = 0.80; homogeneity p-value = 4.3E−4). Effects were weaker stratifying on APOL1. FRMD3 SNPS were associated with T2DN, not type 2 diabetes per se, comparing AAs with T2DN to those with diabetes lacking nephropathy. T2DN-associated FRMD3 SNPs were detectable in AAs only after accounting for MYH9, with differential effects for APOL1. These analyses reveal a role for FRMD3 in AA T2DN susceptibility and accounting for c22 nephropathy risk variants can assist in detecting DN susceptibility genes
- …