Pengaruh Intervensi Psikoedukasi Terhadap Tingkat Depresi Pada Pasien Kanker Serviks Yang Menjalani Kemoterapi Di RSUD Dr. Moewardi Surakarta

Cervical cancer is the second largest cancer after breast cancer suffered by many women. Various kinds of cancer treatment one of them is chemotherapy that cause many side effects for the patient, side effects can cause the patient experiencing psychic disorder that is depresi. The impact can be reduced by providing psycho-education. The purpose of this study was to determine the difference of depression level in cervical cancer patients who undergoing chemotherapy at RSUD Dr. Moewardi Surakarta with psychoeducation intervention. This type of research is quantitative, preexperimental with one group pre-post test design technique,sampling is purposive sampling, with 20 respondent. The research instrument used BDI questioner and data analysis is Wilcoxon.. The result of the analysis of depression level depression was obtained ρ value 0.001 with α = 0,05 (ρ <α) it can be concluded that there is influence significantly before and after given psychoeducation intervention to depression level. Suggestions for health workers, especially inpatient nurses, to further increase their concern to overcome the psychological problems experienced by patients with psychoeducation interventions in the implementation of nursing. Keywords: Psychoeducation, Depression, Cervical Cance

Upaya mencegah kelebihan volume cairan Pada pasien chronic kidney disease Dirsud dr.soehadi prijonegoro

Bacground : The prevalence of chronic kidney disease is considered high in Indonesia, and this increase each year. Fluid volume excess which commonly appear as the complication of chronic kidney disease can affect the quality life of the patient. One kind of the symptoms which appear in the fluid volume excess is edema. Improper treatment of patient with chronic kidney disease can affect the sustainability of the patient. Therefore need prevention efforts to avoid fluid volume excess in appropriate treatment for chronic kidney disease. Objective : To describe the prevention efforts the fluid volume excess in patients with chronic kidney disease in the inpatient installation room of sakura at dr. Soehadi Prijonegoro Hospital. Methods : Method used is a descriptive method with a case study approach, conducted in the inpatient installation room of Sakura at dr. Soehadi Prijonegoro Sragen Hospital from the29th to 31st of March, 2016. The data was collected through observation, interviews with patients or relatives of patients, medical records, and further research. Results : The efforts done to prevent the fluid volume excess in the patients with chronic kidney disease is review of vital signs, such as inputs and outputs review, daily body weight check, limit the input of input and output, help to deal with discomfort feeling of fluid restriction, and collaboration in giving diuretics. The problem of fluid volume excesshas not been done, continue intervention. Conclusion : The fluid volume excess problem has not been covered, required for more effective fluid restriction treatment to reduce fluid volume excess, and it is expected to overcome the inconvenience feeling of fluid restriction by giving red guava juice

Domain Swapping and Different Oligomeric States for the Complex Between Calmodulin and the Calmodulin-Binding Domain of Calcineurin A

BACKGROUND: Calmodulin (CaM) is a ubiquitously expressed calcium sensor that engages in regulatory interactions with a large number of cellular proteins. Previously, a unique mode of CaM target recognition has been observed in the crystal structure of a complex between CaM and the CaM-binding domain of calcineurin A. METHODOLOGY/PRINCIPAL FINDINGS: We have solved a high-resolution crystal structure of a complex between CaM and the CaM-binding domain of calcineurin A in a novel crystal form, which shows a dimeric assembly of calmodulin, as observed before in the crystal state. We note that the conformation of CaM in this complex is very similar to that of unliganded CaM, and a detailed analysis revels that the CaM-binding motif in calcineurin A is of a novel '1-11' type. However, using small-angle X-ray scattering (SAXS), we show that the complex is fully monomeric in solution, and a structure of a canonically collapsed CaM-peptide complex can easily be fitted into the SAXS data. This result is also supported by size exclusion chromatography, where the addition of the ligand peptide decreases the apparent size of CaM. In addition, we studied the energetics of binding by isothermal titration calorimetry and found them to closely resemble those observed previously for ligand peptides from CaM-dependent kinases. CONCLUSIONS/SIGNIFICANCE: Our results implicate that CaM can also form a complex with the CaM-binding domain of calcineurin in a 1 ratio 1 stoichiometry, in addition to the previously observed 2 ratio 2 arrangement in the crystal state. At the structural level, going from 2 ratio 2 association to two 1 ratio 1 complexes will require domain swapping in CaM, accompanied by the characteristic bending of the central linker helix between the two lobes of CaM

Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms

Shape-changing materials open an entirely new solution space for a wide range of disciplines: from architecture that responds to the environment and medical devices that unpack inside the body, to passive sensors and novel robotic actuators. While synthetic shape-changing materials are still in their infancy, studies of biological morphing materials have revealed key paradigms and features which underlie efficient natural shape-change. Here, we review some of these insights and how they have been, or may be, translated to artificial solutions. We focus on soft matter due to its prevalence in nature, compatibility with users and potential for novel design. Initially, we review examples of natural shape-changing materials—skeletal muscle, tendons and plant tissues—and compare with synthetic examples with similar methods of operation. Stimuli to motion are outlined in general principle, with examples of their use and potential in manufactured systems. Anisotropy is identified as a crucial element in directing shape-change to fulfil designed tasks, and some manufacturing routes to its achievement are highlighted. We conclude with potential directions for future work, including the simultaneous development of materials and manufacturing techniques and the hierarchical combination of effects at multiple length scales.</p

Valorisation of Biowastes for the Production of Green Materials Using Chemical Methods

With crude oil reserves dwindling, the hunt for a sustainable alternative feedstock for fuels and materials for our society continues to expand. The biorefinery concept has enjoyed both a surge in popularity and also vocal opposition to the idea of diverting food-grade land and crops for this purpose. The idea of using the inevitable wastes arising from biomass processing, particularly farming and food production, is, therefore, gaining more attention as the feedstock for the biorefinery. For the three main components of biomass—carbohydrates, lipids, and proteins—there are long-established processes for using some of these by-products. However, the recent advances in chemical technologies are expanding both the feedstocks available for processing and the products that be obtained. Herein, this review presents some of the more recent developments in processing these molecules for green materials, as well as case studies that bring these technologies and materials together into final products for applied usage