39 research outputs found
Generation of Plasmodium falciparum parasite-inhibitory antibodies by immunization with recombinantly-expressed CyRPA
Proximity, network formation and inventive performance: in search of the proximity paradox
External quality assurance of malaria nucleic acid testing for clinical trials and eradication surveillance
Nucleic acid testing (NAT) for malaria parasites is an increasingly recommended diagnostic endpoint in clinical trials of vaccine and drug candidates and is also important in surveillance of malaria control and elimination efforts. A variety of reported NAT assays have been described, yet no formal external quality assurance (EQA) program provides validation for the assays in use. Here, we report results of an EQA exercise for malaria NAT assays. Among five centers conducting controlled human malaria infection trials, all centers achieved 100% specificity and demonstrated limits of detection consistent with each laboratory's pre-stated expectations. Quantitative bias of reported results compared to expected results was generally <0.5 log10 parasites/mL except for one laboratory where the EQA effort identified likely reasons for a general quantitative shift. The within-laboratory variation for all assays was low at <10% coefficient of variation across a range of parasite densities. Based on this study, we propose to create a Molecular Malaria Quality Assessment program that fulfills the need for EQA of malaria NAT assays worldwide
Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A
The exceptionally broad-based potential of active and passive vaccination targeting the conserved microbial surface polysaccharide PNAG
Identification of an Immunogenic Mimic of a Conserved Epitope on the Plasmodium falciparum Blood Stage Antigen AMA1 Using Virus-Like Particle (VLP) Peptide Display
Single-access transumbilical laparoscopic appendectomy and cholecystectomy using new curved reusable instruments: a pilot feasibility study.
The umbilicus can be considered as the embryological opening for single-access laparoscopic procedures. We report on single-access transumbilical laparoscopic appendectomy (SATLA) and cholecystectomy (SATLC), performed using new curved reusable instruments.Evaluation StudiesJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe
THE ECOLOGY AND MORPHOLOGICAL VARIATION OF MARITES PHYLLODISTOMUM UMBLAE AND PHYLLODISTOMUM FOLIUM (TREMATODE: GORCODERIDAE) - PARASITES OF FISHES, THE BAIKAL LAKE BASIN
The work is aimed at studying the ecology and morphology of the two indicated species of the phyllodistoma and its influence on the micromorphology of the fishes excretory system. Investigated has been the morphological variation and distribution of the marites in the excretory system of the final hosts. The dynamics of the fishes infection with the phyllodistoma has been studied. The micromorphological variations of the fishes excretory system with the invasion by phyllodistoma have been describedAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio