1,479 research outputs found
Nosocomial infection in a newborn intensive care unit (NICU), South Korea
BACKGROUND: This study aimed to determine the occurrence of nosocomial infections (NIs), including infection rates, main infection sites, and common microorganisms. Patients included in the study were taken from a newborn intensive care unit (NICU), in a hospital in South Korea. METHODS: A retrospective cohort study was performed by reviewing chart. The subjects were 489 neonates who were admitted to the NICU, survived longer than 72 hours, and not transferred to another unit, between Jan. 1. 1995 to Sep. 30, 1999. NIs were identified according to the NNIS definition. Data were analyzed with descriptive statistics. RESULTS: Cumulative incidence rate for NIs was 30.3 neonates out of 100 admissions, with a total of 44.6 infections. The incidence density was average 10.2 neonates and 15.1 infections per 1000 patient days. The most common infections were pneumonia (28%), bloodstream infection (26%), and conjunctivitis (22%). Major pathogens were Gram-positives such as Staphylococcus aureus and coagulase-negative staphylococci. The factors associated with NI was less than 1500 g of birth weight, less than 32 weeks of gestational age, and less than 8 of apgar score. There's no statistical difference in discharge status between two groups, but hospital stay was longer in subjects with nosocomial infection than those without infection. CONCLUSION: Although the distribution of pathogens was similar to previous reports, a high rate of nosocomial infection and in particular conjunctivitis was observed in this study that merits further evaluation
Differential geometry with a projection: Application to double field theory
In recent development of double field theory, as for the description of the
massless sector of closed strings, the spacetime dimension is formally doubled,
i.e. from D to D+D, and the T-duality is realized manifestly as a global O(D,D)
rotation. In this paper, we conceive a differential geometry characterized by a
O(D,D) symmetric projection, as the underlying mathematical structure of double
field theory. We introduce a differential operator compatible with the
projection, which, contracted with the projection, can be covariantized and may
replace the ordinary derivatives in the generalized Lie derivative that
generates the gauge symmetry of double field theory. We construct various gauge
covariant tensors which include a scalar and a tensor carrying two O(D,D)
vector indices.Comment: 1+22 pages, No figure; a previous result on 4-index tensor removed,
presentation improve
String theoretic QCD axions in the light of PLANCK and BICEP2
The QCD axion solving the strong CP problem may originate from antisymmetric
tensor gauge fields in compactified string theory, with a decay constant around
the GUT scale. Such possibility appears to be ruled out now by the detection of
tensor modes by BICEP2 and the PLANCK constraints on isocurvature density
perturbations. A more interesting and still viable possibility is that the
string theoretic QCD axion is charged under an anomalous U(1)_A gauge symmetry.
In such case, the axion decay constant can be much lower than the GUT scale if
moduli are stabilized near the point of vanishing Fayet-Illiopoulos term, and
U(1)_A-charged matter fields get a vacuum value far below the GUT scale due to
a tachyonic SUSY breaking scalar mass. We examine the symmetry breaking pattern
of such models during the inflationary epoch with the Hubble expansion rate
10^{14} GeV, and identify the range of the QCD axion decay constant, as well as
the corresponding relic axion abundance, consistent with known cosmological
constraints. In addition to the case that the PQ symmetry is restored during
inflation, there are other viable scenarios, including that the PQ symmetry is
broken during inflation at high scales around 10^{16}-10^{17} GeV due to a
large Hubble-induced tachyonic scalar mass from the U(1)_A D-term, while the
present axion scale is in the range 10^{9}-5\times 10^{13} GeV, where the
present value larger than 10^{12} GeV requires a fine-tuning of the axion
misalignment angle. We also discuss the implications of our results for the
size of SUSY breaking soft masses.Comment: 29 pages, 1 figure; v3: analysis updated including the full
anharmonic effects, references added, version accepted for publication in
JHE
Universality and exactness of Schrodinger geometries in string and M-theory
We propose an organizing principle for classifying and constructing
Schrodinger-invariant solutions within string theory and M-theory, based on the
idea that such solutions represent nonlinear completions of linearized vector
and graviton Kaluza-Klein excitations of AdS compactifications. A crucial
simplification, derived from the symmetry of AdS, is that the nonlinearities
appear only quadratically. Accordingly, every AdS vacuum admits infinite
families of Schrodinger deformations parameterized by the dynamical exponent z.
We exhibit the ease of finding these solutions by presenting three new
constructions: two from M5 branes, both wrapped and extended, and one from the
D1-D5 (and S-dual F1-NS5) system. From the boundary perspective, perturbing a
CFT by a null vector operator can lead to nonzero beta-functions for spin-2
operators; however, symmetry restricts them to be at most quadratic in
couplings. This point of view also allows us to easily prove nonrenormalization
theorems: for any Sch(z) solution of two-derivative supergravity constructed in
the above manner, z is uncorrected to all orders in higher derivative
corrections if the deforming KK mode lies in a short multiplet of an AdS
supergroup. Furthermore, we find infinite classes of 1/4 BPS solutions with
4-,5- and 7-dimensional Schrodinger symmetry that are exact.Comment: 31 pages, plus appendices; v2, minor corrections, added refs, slight
change in interpretation in section 2.3, new Schrodinger and Lifshitz
solutions included; v3, clarifications in sections 2 and 3 regarding
existence of solutions and multi-trace operator
Partonic description of a supersymmetric p-brane
We consider supersymmetric extensions of a recently proposed partonic
description of a bosonic p-brane which reformulates the Nambu-Goto action as an
interacting multi-particle action with Filippov-Lie algebra gauge symmetry. We
construct a worldline supersymmetric action by postulating, among others, a
p-form fermion. Demanding a local worldline supersymmetry rather than the full
worldvolume supersymmetry, we circumvent a known no-go theorem against the
construction of a Ramond-Neveu-Schwarz supersymmetric action for a p-brane of
p>1. We also derive a spacetime supersymmetric Green-Schwarz extension from the
preexisting kappa-symmetric action.Comment: 1+16 pages, no figure; References added and Concluding section
expanded. Final version to appear in JHE
The mu problem and sneutrino inflation
We consider sneutrino inflation and post-inflation cosmology in the singlet
extension of the MSSM with approximate Peccei-Quinn(PQ) symmetry, assuming that
supersymmetry breaking is mediated by gauge interaction. The PQ symmetry is
broken by the intermediate-scale VEVs of two flaton fields, which are
determined by the interplay between radiative flaton soft masses and higher
order terms. Then, from the flaton VEVs, we obtain the correct mu term and the
right-handed(RH) neutrino masses for see-saw mechanism. We show that the RH
sneutrino with non-minimal gravity coupling drives inflation, thanks to the
same flaton coupling giving rise to the RH neutrino mass. After inflation,
extra vector-like states, that are responsible for the radiative breaking of
the PQ symmetry, results in thermal inflation with the flaton field, solving
the gravitino problem caused by high reheating temperature. Our model predicts
the spectral index to be n_s\simeq 0.96 due to the additional efoldings from
thermal inflation. We show that a right dark matter abundance comes from the
gravitino of 100 keV mass and a successful baryogenesis is possible via
Affleck-Dine leptogenesis.Comment: 27 pages, no figures, To appear in JHE
Ramond-Ramond Cohomology and O(D,D) T-duality
In the name of supersymmetric double field theory, superstring effective
actions can be reformulated into simple forms. They feature a pair of vielbeins
corresponding to the same spacetime metric, and hence enjoy double local
Lorentz symmetries. In a manifestly covariant manner --with regard to O(D,D)
T-duality, diffeomorphism, B-field gauge symmetry and the pair of local Lorentz
symmetries-- we incorporate R-R potentials into double field theory. We take
them as a single object which is in a bi-fundamental spinorial representation
of the double Lorentz groups. We identify cohomological structure relevant to
the field strength. A priori, the R-R sector as well as all the fermions are
O(D,D) singlet. Yet, gauge fixing the two vielbeins equal to each other
modifies the O(D,D) transformation rule to call for a compensating local
Lorentz rotation, such that the R-R potential may turn into an O(D,D) spinor
and T-duality can flip the chirality exchanging type IIA and IIB
supergravities.Comment: 1+37 pages, no figure; Structure reorganized, References added, To
appear in JHEP. cf. Gong Show of Strings 2012
(http://wwwth.mpp.mpg.de/members/strings/strings2012/strings_files/program/Talks/Thursday/Gongshow/Lee.pdf
Effect of microneedles on transdermal permeation enhancement of amlodipine
The present study aimed to investigate the effect of microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation enhancement of amlodipine (AMLO). Two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PM) of 0.6 mm length were employed. In the case of PMs, arrays were applied thrice at different places within a 1.77-cm2 skin area (PM-3) to maintain the MN density closer to 0.6 mm ADM. Scaling analyses were done using dimensionless parameters like concentration of AMLO (Ct/Cs), thickness (h/L) and surface area of the skin (Sa/L2). Microinjection moulding technique was employed to fabricate PM. Histological studies revealed that the PM, owing to their geometry/design, formed wider and deeper microconduits when compared to ADM of similar length. Approximately 6.84- and 6.11-fold increase in the cumulative amount (48 h) of AMLO permeated was observed with 1.5 mm ADM and PM-3 treatments respectively, when compared to passive permeation amounts. Good correlations (R2 > 0.89) were observed between different dimensionless parameters with scaling analyses. The enhancement in AMLO permeation was found to be in the order of 1.5 mm ADM ≥ PM-3 > 1.2 mm ADM > 0.6 mm ADM ≥PM-1 > passive. The study suggests that MN application enhances the AMLO transdermal permeation and the geometrical parameters of MNs play an important role in the degree of such enhancement
Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs. Recently, it has been indicated that a topical application of the sphingolipid sphingosine 1-phosphate (S1P) prevents the inflammatory response in CHS, but the molecular mechanism is not fully elucidated. Here we indicate that treatment of mice with S1P is connected with an impaired antigen uptake by Langerhans cells (LCs), the initial step of CHS. Most of the known actions of S1P are mediated by a family of five specific G protein-coupled receptors. Our results indicate that S1P inhibits macropinocytosis of the murine LC line XS52 via S1P2 receptor stimulation followed by a reduced phosphatidylinositol 3-kinase (PI3K) activity. As down-regulation of S1P2 not only diminished S1P-mediated action but also enhanced the basal activity of LCs on antigen capture, an autocrine action of S1P has been assumed. Actually, S1P is continuously produced by LCs and secreted via the ATP binding cassette transporter ABCC1 to the extracellular environment. Consequently, inhibition of ABCC1, which decreased extracellular S1P levels, markedly increased the antigen uptake by LCs. Moreover, stimulation of sphingosine kinase activity, the crucial enzyme for S1P formation, is connected not only with enhanced S1P levels but also with diminished antigen capture. These results indicate that S1P is essential in LC homeostasis and influences skin immunity. This is of importance as previous reports suggested an alteration of S1P levels in atopic skin lesions
Churg-Strauss syndrome following cessation of allergic desensitization vaccination: a case report
<p>Abstract</p> <p>Introduction</p> <p>Churg-Strauss syndrome is a vasculitis of medium to small sized vessels. Diagnosis is mainly clinical with findings of asthma, eosinophilia, rhinosinusitis and signs of vasculitis in major organs.</p> <p>Case presentation</p> <p>We present a case of a 19-year-old Persian male who developed signs and symptoms of this syndrome related to hyposensitization treatments for allergy control.</p> <p>Conclusions</p> <p>No unifying etiology for the disease can be presented as it is found associated with environmental factors, medications, infections and is even considered a variant of asthma with predisposition to vasculitic involvement. Therefore, it is important to recognize this disease and be aware of underdiagnosis because of emphasis on pathologic evidence. Here, we present a case of allergic desensitization causing Churg-Strauss syndrome in the absence of other known factors.</p
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