84 research outputs found
<Abstract of published report>Chemoprevention of N-Methyl-N-nitrosourea-induced Rat Glandular Stomach Carcinogenesis by a Natural Product-Protocatechuic Acid.
<Abstract of published report>Chemoprevention of Rat Oral Carcinogenesis by Naturally Occurring Xanthophylls, Astaxanthin and Canthaxanthin.
<Abstract of published report>Suppression of Azoxymethane-induced Rat Colon Carcinogenesis by Dietary Administration of Naturally Occurring Xanthophylls Astaxanthin and Canthaxanthin During the Postinitiation Phase.
<Abstract of published report>Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Dietary Feeding of S-Methyl Methane Thiosulfonatein Male F344 Rats.
Physicochemical Properties of Chlorophylls in Oxygenic Photosynthesis — Succession of Co-Factors from Anoxygenic to Oxygenic Photosynthesis
Inhibitory effects of caraway (Carum carvi L.) and its component on N -methyl-N ’-nitro-N -nitrosoguanidineinduced mutagenicity
To elucidate the mechanism of antimutagenicity of caraway, we examined the effects of caraway seed extract on N-methyl-N’-nitro-N-nitrosoguanidine (MNNG)-induced mutagenesis in DNA methyltransferase-deficient Salmonella typhimurium strains, O6-methylguanineDNA adduct formation, and thiol content in S. typhimurium cells. MNNG was highly mutagenic for ogt- strains YG7104(ogt- ada+) and YG7108 (ogt-ada-), and it showed slightly higher mutagenicity in strain YG7100 (ogt+ ada-) than in strains TA100 and TA1535. Hot water extract of caraway seeds inhibited MNNG-induced mutation only in the ogt+ strains. In the presence of caraway extract, O6-methylguanine DNA adducts in strain YG7100 were decreased in proportion to the decrease of MNNG-induced mutagenesis. Although MNNG is known to degrade in the presence of thiols to produce methyl cation which can react with DNA, caraway had no effect on cellular concentrations of acid-soluble thiols. These results indicate that caraway does not directly inactivate MNNG and that Ogt-O6-methylguanine-DNAmethyltransferasemay be involved in the antimutagenic activity of caraway
<Abstract of published report>Inhibition of 4-Nitroquinoline-1-oxide-induced Rat Oral Carcinogenesis by Dietary Exposure of a New Retionoidal Butenolide, KYN-54,During the Initiation and Post-initiation Phases.
<Abstract of published report>Chemoprevention of 4-Nitroquinoline 1-Oxide-Induced Oral Carcinogenesis by Dietary Curcumin and Hesperidin : Comparison with the Protective Effect of β-Carotene.
<Abstract of published report>Chemopreventive Effect of a Xanthine Oxidase Inhibitor, l\u27-Acetoxychavicol Acetate, on Rat Oral Carcinogenesis.
<Abstract of Published Report>Two Novel Diterpenoids, Erinacines H and I from the Mycelia of Hericium erinaceum.
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