DESENVOLVIMENTO INICIAL DE CULTIVARES DE MELÃO FERTIRRIGADAS COM DISTINTAS PROPORÇÕES DE ESGOTO DOMÉSTICO EM MOSSORÓ-RN

The inadequacy of sewage systems and water shortages in semi-arid Northeast is encouraging the reuse of water in the production of agricultural crops. This study aimed to analyze the effect of treated do- mestic sewage in the initial development of three melon cultivars in Mossoró-RN. The experiment was mounted on a split-plot in randomized blocks with plots cultivars of melon (Yellow Tikal, Cantaloupe type Harper and Gália) and the split-plots the proportions of water supply and domestic sewage (T1 - 100% water supply T2 - 50% of water supply and 50% of domestic sewage, T3 - 25% of water supply and 75% of domestic sewage and T4 - 100% domestic sewage) in three replicates. In the experimental period were analyzed for physico-chemical and microbiological characteristics of sewage and water supply. At 20 days after sowing was measured plant height, stem length, root length and stem diameter. The results showed that the fertirrigation of melon cultivars with domestic sewage minimizes the effect of water scarcity in semiarid. The development of cultivar Gália seedlings was not affected by application of primary domestic sewage. The T2 and T4 were the most suitable for the production of cultivar Gália seedlings

Uma etnologia dos "índios misturados"? Situação colonial, territorialização e fluxos culturais

Até recentemente os estudos sobre os povos e culturas indígenas do Nordeste brasileiro não constituíram um objeto mais sistemático de investigações, parecendo apenas propiciar uma etnologia secundária e menor. Na visão do autor, isso decorreu da dificuldade de aplicação àquelas culturas dos pressupostos da antropologia americanista, a qual opera com modelos societários que enfatizam a descontinuidade cultural, bem como a objetividade e a exterioridade do observado em face do pesquisador e de sua sociedade. Dialogando com diferentes perspectivas teóricas, o autor delineia ou reelabora algumas noções como, respectivamente, as de "territorialização", "situação colonial", "diáspora" e "viagem da volta" que lhe permitem realizar uma análise compreensiva do processo histórico que veio a transformar tais populações nos grupos étnicos atuais. Sugere, ao final, que os estudos que vêm sendo realizados no Brasil e em diferentes partes do mundo sobre "índios misturados" (isto é, relações interétnicas em áreas de colonização muito antiga) podem contribuir para a construção de uma antropologia mais articulada com a história.<br>Until quite recently, indigenous peoples in the Brazilian Northeast were not the object of systematic investigation, rather appearing to inspire a kind of secondary, lesser ethnology. According to the author, this oversight resulted from a difficulty in applying the premises of Americanist anthropology to such cultures, since the latter operates with societal models emphasizing both cultural discontinuity and the objectivity and externality of the observed vis-à-vis the researcher and his/her society. By establishing a dialogue with different theoretical perspectives, the author delineates or reworks several notions, such as "territorialization", "colonial situation", "diaspora", and "return journey", allowing him to produce a comprehensive analysis of the historical process which turned such populations into the current ethnic groups. Finally, he suggests that studies on "mixed Indians" (i.e., relations between ethnic groups in areas of very old colonization) in Brazil and elsewhere can help construct an anthropology that is better articulated with history

Relações entre profissionais de saúde e usuários durante as práticas em saúde Relationships between health professionals and users throughout health care practices

Apresenta-se uma revisão integrativa sobre estudos que abordam as relações entre profissionais de saúde e usuários durante as práticas em saúde. Objetivou-se identificar os aspectos pesquisados no cotidiano dos serviços acerca dessas relações. A coleta foi realizada nas bases Lilacs e Pubmed segundo os descritores: acolhimento; relações profissional-família; relações profissional-paciente; humanização da assistência; e a palavra 'vínculo' associada ao descritor Sistema Único de Saúde. Selecionaram-se 290 estudos publicados entre 1990 e 2010. Por meio da análise temática, foram criados cinco núcleos de sentido: a relevância da confiança na relação profissional-usuário; sentimentos e sentidos na prática do cuidado; a importância da comunicação nos serviços de saúde; modo de organização das práticas em saúde; e (des)colonialismo. Identificou-se que as relações estabelecidas nas práticas de saúde têm uma dimensão transformadora. No entanto, permanece o desafio de humanizar os serviços de saúde. A enfermagem se destaca na produção do conhecimento nessa temática.<br>This article presents an integrative review about studies that address the relationships between health professionals and users in health care practices. It aimed to identify aspects that were researched on the daily life of the services concerning such relationships. Data were collected from the Lilacs and Pubmed databases based on these descriptors: user embracement; professionalfamily relations; professionalpatient relations; humanization of the care; and the bonding word associated to the Single Health System descriptor. Two hundred and ninety studies, published from 1990 to 2010, were selected. Through thematic analyses, five meaning cores were created: the relevance of the confidence in the professionaluser relationship; feelings and senses in the health care practice; the importance of communications in health care services; ways to organize health care practices and (de)colonialism. It was found that relationships established in health care practices have a transformative dimension. However, the challenge to humanize health care services remains. Nursing stands out in the production of knowledge on such theme

A randomized trial of planned cesarean or vaginal delivery for twin pregnancy

Background: Twin birth is associated with a higher risk of adverse perinatal outcomes than singleton birth. It is unclear whether planned cesarean section results in a lower risk of adverse outcomes than planned vaginal delivery in twin pregnancy.\ud \ud Methods: We randomly assigned women between 32 weeks 0 days and 38 weeks 6 days of gestation with twin pregnancy and with the first twin in the cephalic presentation to planned cesarean section or planned vaginal delivery with cesarean only if indicated. Elective delivery was planned between 37 weeks 5 days and 38 weeks 6 days of gestation. The primary outcome was a composite of fetal or neonatal death or serious neonatal morbidity, with the fetus or infant as the unit of analysis for the statistical comparison.\ud \ud Results: A total of 1398 women (2795 fetuses) were randomly assigned to planned cesarean delivery and 1406 women (2812 fetuses) to planned vaginal delivery. The rate of cesarean delivery was 90.7% in the planned-cesarean-delivery group and 43.8% in the planned-vaginal-delivery group. Women in the planned-cesarean-delivery group delivered earlier than did those in the planned-vaginal-delivery group (mean number of days from randomization to delivery, 12.4 vs. 13.3; P = 0.04). There was no significant difference in the composite primary outcome between the planned-cesarean-delivery group and the planned-vaginal-delivery group (2.2% and 1.9%, respectively; odds ratio with planned cesarean delivery, 1.16; 95% confidence interval, 0.77 to 1.74; P = 0.49).\ud \ud Conclusion: In twin pregnancy between 32 weeks 0 days and 38 weeks 6 days of gestation, with the first twin in the cephalic presentation, planned cesarean delivery did not significantly decrease or increase the risk of fetal or neonatal death or serious neonatal morbidity, as compared with planned vaginal delivery

Neoantigen-directed immune escape in lung cancer evolution

The interplay between an evolving cancer and a dynamic immune microenvironment remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell lung cancers using RNA sequencing and histopathology-assessed tumour-infiltrating lymphocyte estimates. Immune infiltration varied both between and within tumours, with different mechanisms of neoantigen presentation dysfunction enriched in distinct immune microenvironments. Sparsely infiltrated tumours exhibited a waning of neoantigen editing during tumour evolution, indicative of historical immune editing, or copy-number loss of previously clonal neoantigens. Immune-infiltrated tumour regions exhibited ongoing immunoediting, with either loss of heterozygosity in human leukocyte antigens or depletion of expressed neoantigens. We identified promoter hypermethylation of genes that contain neoantigenic mutations as an epigenetic mechanism of immunoediting. Our results suggest that the immune microenvironment exerts a strong selection pressure in early-stage, untreated non-small-cell lung cancers that produces multiple routes to immune evasion, which are clinically relevant and forecast poor disease-free survival.status: publishe