Human factors in forensic science: The cognitive mechanisms that underlie forensic feature-comparison expertise

After a decade of critique from leading scientific bodies, forensic science research is at a crossroads. Whilst emerging research has shown that some forensic feature-comparison disciplines are not foundationally valid, others are moving towards establishing reliability and validity. Forensic examiners in fingerprint, face and handwriting comparison disciplines have skills and knowledge that distinguish them from novices. Yet our understanding of the basis of this expertise is only beginning to emerge. In this paper, we review evidence on the psychological mechanisms contributing to forensic feature-comparison expertise, with a focus on one mechanism: statistical learning, or the ability to learn how often things occur in the environment. Research is beginning to emphasise the importance of statistical learning in forensic feature-comparison expertise. Ultimately, this research and broader cognitive science research has an important role to play in informing the development of training programs and selection tools for forensic feature-comparison examiners

Compared cost evaluation among traditional versus innovative strait crossing solutions

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Design aspects of the AB prototype in the Qiandao Lake

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Cable supported immersed inversed bridge: A challenging proposal

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Seismic analysis of a SFT solution for the Messina Strait crossing

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Morphological Analysis of the Polarized Synchrotron Emission with WMAP and Planck

The bright polarized synchrotron emission, away from the Galactic plane, originates mostly from filamentary structures. We implement a filament finder algorithm which allows the detection of bright elongated structures in polarized intensity maps. We analyse the sky at 23 and 30 GHz as observed respectively by WMAP and Planck. We identify 19 filaments, 13 of which have been previously observed. For each filament, we study the polarization fraction, finding values typically larger than for the areas outside the filaments, excluding the Galactic plane, and a fraction of about 30% is reached in two filaments. We study the polarization spectral indices of the filaments, and find a spectral index consistent with the values found in previous analysis (about -3.1) for more diffuse regions. Decomposing the polarization signals into the $E$ and $B$ families, we find that most of the filaments are detected in $P_E$, but not in $P_B$. We then focus on understanding the statistical properties of the diffuse regions of the synchrotron emission at 23 GHz. Using Minkowski functionals and tensors, we analyse the non-Gaussianity and statistical isotropy of the polarized intensity maps. For a sky coverage corresponding to 80% of the fainter emission, and on scales smaller than 6 degrees ($\ell > 30$), the deviations from Gaussianity and isotropy are significantly higher than 3$\sigma$. The level of deviation decreases for smaller scales, however, it remains significantly high for the lowest analised scale ($\sim 1.5^\circ$). When 60% sky coverage is analysed, we find that the deviations never exceed 3$\sigma$. Finally, we present a simple data-driven model to generate non-Gaussian and anisotropic simulations of the synchrotron polarized emission. The simulations are fitted in order to match the spectral and statistical properties of the faintest 80% sky coverage of the data maps.Comment: 35 pages, 17 figure

One step closer to influenza vaccine inclusiveness

Flu virus infection is a common cause of acute respiratory illness, with the major incidence in pediatric age, high morbidity, and mortality. The flu vaccine is recommended for all people aged ≥6 months, unless specific contraindications are present. Younger and older age, pregnancy, chronic diseases like asthma, and immunodeficiency are risk factors for severe complications following flu infection. Thus, these categories represent the target for flu vaccine strategies in most countries. Inactivated influenza vaccine (IIV), recombinant influenza vaccine (RIV) or live‐attenuated influenza virus (LAIV) are currently available, with specific precautions and contraindications. We aim to resume the current indications for vaccines in the vulnerable populations to support flu vaccination inclusiveness, in anticipation of a “universal vaccine” strategy

PARP-1 modulates amyloid beta peptide-induced neuronal damage.

Amyloid beta peptide (A beta) causes neurodegeneration by several mechanisms including oxidative stress, which is known to induce DNA damage with the consequent activation of poly (ADP-ribose) polymerase (PARP-1). To elucidate the role of PARP-1 in the neurodegenerative process, SH-SY5Y neuroblastoma cells were treated with A beta(25-35) fragment in the presence or absence of MC2050, a new PARP-1 inhibitor. A beta(25-35) induces an enhancement of PARP activity which is prevented by cell pre-treatment with MC2050. These data were confirmed by measuring PARP-1 activity in CHO cells transfected with amylod precursor protein and in vivo in brains specimens of TgCRND8 transgenic mice overproducing the amyloid peptide. Following A beta(25-35) exposure a significant increase in intracellular ROS was observed. These data were supported by the finding that A beta(25-35) induces DNA damage which in turn activates PARP-1. Challenge with A beta(25-35) is also able to activate NF-kB via PARP-1, as demonstrated by NF-kB impairment upon MC2050 treatment. Moreover, A beta(25-35) via PARP-1 induces a significant increase in the p53 protein level and a parallel decrease in the anti-apoptotic Bcl-2 protein. These overall data support the hypothesis of PARP-1 involvment in cellular responses induced by A beta and hence a possible rationale for the implication of PARP-1 in neurodegeneration is discussed