32,365 research outputs found
Differential-geometric approach to the integrability of hydrodynamic chains: the Haantjes tensor
The integrability of an m-component system of hydrodynamic type, u_t=V(u)u_x,
by the generalized hodograph method requires the diagonalizability of the mxm
matrix V(u). This condition is known to be equivalent to the vanishing of the
corresponding Haantjes tensor. We generalize this approach to hydrodynamic
chains -- infinite-component systems of hydrodynamic type for which the
infinite matrix V(u) is `sufficiently sparse'. For such systems the Haantjes
tensor is well-defined, and the calculation of its components involves finite
summations only. We illustrate our approach by classifying broad classes of
conservative and Hamiltonian hydrodynamic chains with the zero Haantjes tensor.
We prove that the vanishing of the Haantjes tensor is a necessary condition for
a hydrodynamic chain to possess an infinity of semi-Hamiltonian hydrodynamic
reductions, thus providing an easy-to-verify necessary condition for the
integrability.Comment: 36 pages, the classification results and proofs are refined. A
section on generating functions is adde
The use of ERTS-1 to more fully utilize and apply marine station data to the study and productivity along the eastern shelf waters of the United States
The author has identified the following significant results. Sea truth data were obtained during two ERTS overpasses in waters near the entrance of the Chesapeake Bay. Correlations were made between total phytoplankton and chlorophyll values in these waters to radiance detected by ERTS in an effort to map areas of similar productivity levels. Band 4 radiance had the highest correlation to all parameters with bands 5 and 6 showing decreasing correlations in each case. The radiance values were apparently influenced by one or more factors, most likely including the sediment content of the water. Data have shown that ERTS MSS is not suitable for monitoring chlorophyll in near-shore waters where sediment loads are high. It is suggested that in more seaward or pelagic locations, that ERTS MSS would be more efficient in monitoring surface chlorophyll values and establishing direct relationships to phytoplankton concentrations
Imaging X-ray spectrometer
An X-ray spectrometer for providing imaging and energy resolution of an X-ray source is described. This spectrometer is comprised of a thick silicon wafer having an embedded matrix or grid of aluminum completely through the wafer fabricated, for example, by thermal migration. The aluminum matrix defines the walls of a rectangular array of silicon X-ray detector cells or pixels. A thermally diffused aluminum electrode is also formed centrally through each of the silicon cells with biasing means being connected to the aluminum cell walls and causes lateral charge carrier depletion between the cell walls so that incident X-ray energy causes a photoelectric reaction within the silicon producing collectible charge carriers in the form of electrons which are collected and used for imaging
Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b
BACKGROUND: There have been indications that common Angiotensin Receptor Blockers (ARBs) may be exerting anti-inflammatory actions by directly modulating the immune system. We decided to use molecular modelling to rapidly assess which of the potential targets might justify the expense of detailed laboratory validation. We first studied the VDR nuclear receptor, which is activated by the secosteroid hormone 1,25-dihydroxyvitamin-D. This receptor mediates the expression of regulators as ubiquitous as GnRH (Gonadatrophin hormone releasing hormone) and the Parathyroid Hormone (PTH). Additionally we examined Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma), which affects the function of phagocytic cells, and the C-CChemokine Receptor, type 2b, (CCR2b), which recruits monocytes to the site of inflammatory immune challenge. RESULTS: Telmisartan was predicted to strongly antagonize (Ki≈0.04nmol) the VDR. The ARBs Olmesartan, Irbesartan and Valsartan (Ki≈10 nmol) are likely to be useful VDR antagonists at typical in-vivo concentrations. Candesartan (Ki≈30 nmol) and Losartan (Ki≈70 nmol) may also usefully inhibit the VDR. Telmisartan is a strong modulator of PPARgamma (Ki≈0.3 nmol), while Losartan (Ki≈3 nmol), Irbesartan (Ki≈6 nmol), Olmesartan and Valsartan (Ki≈12 nmol) also seem likely to have significant PPAR modulatory activity. Olmesartan andIrbesartan (Ki≈9 nmol) additionally act as antagonists of a theoretical modelof CCR2b. Initial validation of this CCR2b model was performed, and a proposed model for the AngiotensinII Type1 receptor (AT2R1) has been presented. CONCLUSION: Molecular modeling has proven valuable to generate testable hypotheses concerning receptor/ligand binding and is an important tool in drug design. ARBs were designed to act as antagonists for AT2R1, and it was not surprising to discover their affinity for the structurally similar CCR2b. However, this study also found evidence that ARBs modulate the activation of two key nuclear receptors-VDR and PPARgamma. If our simulations are confirmed by experiment, it is possible that ARBs may become useful as potent anti-inflammatory agents, in addition to their current indication as cardiovascular drugs
Radiative Properties of the Stueckelberg Mechanism
We examine the mechanism for generating a mass for a U(1) vector field
introduced by Stueckelberg. First, it is shown that renormalization of the
vector mass is identical to the renormalization of the vector field on account
of gauge invariance. We then consider how the vector mass affects the effective
potential in scalar quantum electrodynamics at one-loop order. The possibility
of extending this mechanism to couple, in a gauge invariant way, a charged
vector field to the photon is discussed.Comment: 8 pages, new Introduction, added Reference
On syntheses of the X-ray background with power-law sources
The conditions under which the combined emission from power law sources can mimic the X-ray background (XRB) spectrum in the 3-50 keV range are considered in view of HEAO 1 A-2 experiment measurements, and it is confirmed that a good fit may be obtained. The required spectral properties of the component sources differ, however, from those observed for local active galactic nuclei. Constraints are deduced for both the low luminosity extension and evolution of such local objects, and it is shown that any other class of sources contributing to the X-ray background must be characterized by an energy spectral index lower than about 0.4, which is the mean index of the XRB, and exhibit sleeper spectra at higher energies
Spin dynamics of heterometallic Cr7M wheels (M = Mn, Zn, Ni) probed by inelastic neutron scattering
Inelastic neutron scattering has been applied to the study of the spin
dynamics of Cr-based antiferromagnetic octanuclear rings where a finite total
spin of the ground state is obtained by substituting one Cr(III) ion (s = 3/2)
with Zn (s = 0), Mn (s = 5/2) or Ni (s = 1) di-cations. Energy and intensity
measurements for several intra-multiplet and inter-multiplet magnetic
excitations allow us to determine the spin wavefunctions of the investigated
clusters. Effects due to the mixing of different spin multiplets have been
considered. Such effects proved to be important to correctly reproduce the
energy and intensity of magnetic excitations in the neutron spectra. On the
contrary to what is observed for the parent homonuclear Cr8 ring, the symmetry
of the first excited spin states is such that anticrossing conditions with the
ground state can be realized in the presence of an external magnetic field.
Heterometallic Cr7M wheels are therefore good candidates for macroscopic
observations of quantum effects.Comment: 9 pages, 11 figures, submitted to Phys. Rev. B, corrected typos and
added references, one sentence change
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