7,130 research outputs found
Heat shock protein expression in canine malignant mammary tumours.
Background
Abnormal levels of Heat Shock Proteins (HSPs) have been observed in many human neoplasms including breast cancer and it has been demonstrated that they have both prognostic and therapeutic implications. In this study, we evaluated immunohistochemical expression of HSPs in normal and neoplastic canine mammary glands and confronted these results with overall survival (OS), in order to understand the role of HSPs in carcinogenesis and to establish their potential prognostic and/or therapeutic value.
Methods
Immunohistochemical expression of Hsp27, Hsp72, Hsp73 and Hsp90 was evaluated in 3 normal canine mammary glands and 30 malignant mammary tumours (10 in situ carcinomas, 10 invasive carcinomas limited to local structures without identifiable invasion of blood or lymphatic vessels, 10 carcinomas with invasion of blood or lymphatic vessels and/or metastases to regional lymph nodes). A semi-quantitative method was used for the analysis of the results.
Results
Widespread constitutive expression of Hsp73 and Hsp90 was detected in normal tissue, Hsp72 appeared to be focally distributed and Hsp27 showed a negative to rare weak immunostaining. In mammary tumours, a significant increase in Hsp27 (P < 0.01), Hsp72 (P < 0.05) and Hsp90 (P < 0.01) expression was observed as well as a significant reduction in Hsp73 (P < 0.01) immunoreactivity compared to normal mammary gland tissue. Hsp27 demonstrated a strong positivity in infiltrating tumour cells and metaplastic squamous elements of invasive groups. High Hsp27 expression also appeared to be significantly correlated to a shorter OS (P = 0.00087). Intense immunolabelling of Hsp72 and Hsp73 was frequently detected in infiltrative or inflammatory tumour areas. Hsp90 expression was high in all tumours and, like Hsp73, it also showed an intense positivity in lymphatic emboli.
Conclusion
These results suggest that Hsp27, Hsp72 and Hsp90 are involved in canine mammary gland carcinogenesis. In addition, Hsp27 appears to be implicated in tumour invasiveness and its high immunodetection in invasive tumours is indicative of a poorer clinical outcome
Time-dependent Hamiltonian estimation for Doppler velocimetry of trapped ions
The time evolution of a closed quantum system is connected to its Hamiltonian
through Schroedinger's equation. The ability to estimate the Hamiltonian is
critical to our understanding of quantum systems, and allows optimization of
control. Though spectroscopic methods allow time-independent Hamiltonians to be
recovered, for time-dependent Hamiltonians this task is more challenging. Here,
using a single trapped ion, we experimentally demonstrate a method for
estimating a time-dependent Hamiltonian of a single qubit. The method involves
measuring the time evolution of the qubit in a fixed basis as a function of a
time-independent offset term added to the Hamiltonian. In our system the
initially unknown Hamiltonian arises from transporting an ion through a static,
near-resonant laser beam. Hamiltonian estimation allows us to estimate the
spatial dependence of the laser beam intensity and the ion's velocity as a
function of time. This work is of direct value in optimizing transport
operations and transport-based gates in scalable trapped ion quantum
information processing, while the estimation technique is general enough that
it can be applied to other quantum systems, aiding the pursuit of high
operational fidelities in quantum control.Comment: 10 pages, 8 figure
Vacuum Polarization and the Electric Charge of the Positron
We show that higher-order vacuum polarization would contribute a measureable
net charge to atoms, if the charges of electrons and positrons do not balance
precisely. We obtain the limit for the sum of
the charges of electron and positron. This also constitutes a new bound on
certain violations of PCT invariance.Comment: 9 pages, 1 figure attached as PostScript file, DUKE-TH-92-38. Revised
versio
ENDOCRINE DISRUPTING CHEMICALS: EFFECTS ON PITUITARY, THYROID AND ADRENAL GLANDS
BACKGROUND: In recent years, scientific research has increasingly focused on Endocrine Disrupting Chemicals (EDCs) and demonstrated their relevant role in the functional impairment of endocrine glands. This induced regulatory authorities to ban some of these compounds and to carefully investigate others in order to prevent EDCs-related conditions. As a result, we witnessed a growing awareness and interest on this topic. AIMS: This paper aims to summarize current evidence regarding the detrimental effects of EDCs on pivotal endocrine glands like pituitary, thyroid and adrenal ones. Particularly, we directed our attention on the known and the hypothesized mechanisms of endocrine dysfunction brought by EDCs. We also gave a glimpse on recent findings from pioneering studies that could in the future shed a light on the pathophysiology of well-known, but poorly understood, endocrine diseases like hormone-producing adenomas. CONCLUSIONS: Although intriguing, studies on endocrine dysfunctions brought by EDCs are challenging, in particular when investigating long-term effects of EDCs on humans. However, undoubtedly, it represents a new intriguing field of science research
Electric Charge Quantization
Experimentally it has been known for a long time that the electric charges of
the observed particles appear to be quantized. An approach to understanding
electric charge quantization that can be used for gauge theories with explicit
factors -- such as the standard model and its variants -- is
pedagogically reviewed and discussed in this article. This approach uses the
allowed invariances of the Lagrangian and their associated anomaly cancellation
equations. We demonstrate that charge may be de-quantized in the
three-generation standard model with massless neutrinos, because differences in
family-lepton--numbers are anomaly-free. We also review the relevant
experimental limits. Our approach to charge quantization suggests that the
minimal standard model should be extended so that family-lepton--number
differences are explicitly broken. We briefly discuss some candidate extensions
(e.g. the minimal standard model augmented by Majorana right-handed neutrinos).Comment: 18 pages, LaTeX, UM-P-92/5
Eigenvalue distributions for some correlated complex sample covariance matrices
The distributions of the smallest and largest eigenvalues for the matrix
product , where is an complex Gaussian matrix
with correlations both along rows and down columns, are expressed as determinants. In the case of correlation along rows, these expressions are
computationally more efficient than those involving sums over partitions and
Schur polynomials reported recently for the same distributions.Comment: 11 page
Algebraic Fermi liquid from phase fluctuations: "topological" fermions, vortex "berryons" and QED3 theory of cuprate superconductors
Within the phase fluctuation model for the pseudogap state of cuprate
superconductors we identify a novel statistical "Berry phase" interaction
between the nodal quasiparticles and fluctuating vortices. The effective action
describing this model assumes the form of an anisotropic Euclidean quantum
electrodynamics in (2+1) dimensions (QED_3) and naturally generates the
marginal Fermi liquid behavior for its fermionic excitations. The doping axis
in the x-T phase diagram emerges as a quantum critical line which regulates low
energy fermiology. We examine the merits of our theory in light of available
experiments.Comment: 5 pages REVTeX + 2 PostScript Figures. Final version to appear in PR
- …