A multi-material transport problem and its convex relaxation via rectifiable GG-currents

In this paper we study a variant of the branched transportation problem, that we call multi-material transport problem. This is a transportation problem, where distinct commodities are transported simultaneously along a network. The cost of the transportation depends on the network used to move the masses, as it is common in models studied in branched transportation. The main novelty is that in our model the cost per unit length of the network does not depend only on the total flow, but on the actual quantity of each commodity. This allows to take into account different interactions between the transported goods. We propose an Eulerian formulation of the discrete problem, describing the flow of each commodity through every point of the network. We provide minimal assumptions on the cost, under which existence of solutions can be proved. Moreover, we prove that, under mild additional assumptions, the problem can be rephrased as a mass minimization problem in a class of rectifiable currents with coefficients in a group, allowing to introduce a notion of calibration. The latter result is new even in the well studied framework of the "single-material" branched transportation.Comment: Accepted: SIAM J. Math. Ana

Directed energy deposition of AISI 316L stainless steel powder: Effect of process parameters

During Laser Powder-Directed Energy Deposition (LP-DED), many complex phenomena occur. These phenomena, which are strictly related to the conditions used during the building process, can affect the quality of the parts in terms of microstructural features and mechanical behavior. This paper investigates the effect of building parameters on the microstructure and the tensile properties of AISI 316L stainless-steel samples produced via LP-DED. Firstly, the building parameters were selected starting from single scan tracks by studying their morphology and geometrical features. Next, 316L LP-DED bulk samples built with two sets of parameters were characterized in terms of porosity, geometrical accuracy, microstructure, and mechanical properties. The tensile tests data were analyzed using the Voce model and a correlation between the tensile properties and the dislocation free path was found. Overall, the data indicate that porosity should not be considered the unique indicator of the quality of an LP-DED part and that a mechanical characterization should also be performed

A computational approach for the discovery of protein–RNA networks

Protein–RNA interactions play important roles in a wide variety of cellular processes, ranging from transcriptional and posttranscriptional regulation of genes to host defense against pathogens. In this chapter we present the computational approach catRAPID to predict protein–RNA interactions and discuss how it could be used to find trends in ribonucleoprotein networks. We envisage that the combination of computational and experimental approaches will be crucial to unravel the role of coding and noncoding RNAs in protein networks

Microstructure and hardness evolution of solution annealed inconel 625/TiC composite processed by laser powder bed fusion

This study deals with the Inconel 625 (IN625) alloy reinforced with micro-TiC particles processed by laser powder bed fusion. The microstructure and hardness in the as-built and solution-annealed states were investigated. The microstructures of the as-built IN625 and IN625/TiC states were primarily made up of columnar grains along the building direction. After the solution annealing at 1150 °C for 2 h, the IN625 alloy consisted of equiaxed grains due to recrystallization and grain growth. On the contrary, the solution-annealed IN625/TiC composite still presented columnar grains. Therefore, the TiC particles hinder the recrystallization, indicating higher microstructure stability for the composite. For the IN625/TiC composite, both the reduced alteration of the grains and the more intensive formation of carbides prevent a remarkable hardness reduction in the so-lution-annealed state

Classical analysis of phase-locking transients and Rabi-type oscillations in microwave-driven Josephson junctions

We present a classical analysis of the transient response of Josephson junctions perturbed by microwaves and thermal fluctuations. The results include a specific low frequency modulation in phase and amplitude behavior of a junction in its zero-voltage state. This transient modulation frequency is linked directly to an observed variation in the probability for the system to switch to its non-zero voltage state. Complementing previous work on linking classical analysis to the experimental observations of Rabi-oscillations, this expanded perturbation method also provides closed form analytical results for attenuation of the modulations and the Rabi-type oscillation frequency. Results of perturbation analysis are compared directly (and quantitatively) to numerical simulations of the classical model as well as published experimental data, suggesting that transients to phase-locking are closely related to the observed oscillations.Comment: 18 pages total, 8 figures (typos corrected; minor revisions to figures and equations

Structural pattern and functional correlations of the long bone diaphyses intracortical vascular system: investigation carried out with China ink perfusion and multiplanar analysis in the rabbit femur.

The intracortical vessel system of the rabbit femur has been studied after perfusion of the vascular tree with a water solution of dye (China ink) with multiplanar analysis. This method utilizes the full depth of field of the microscope objectives focusing different planes of the thick cortex. The microscopic observation even if restricted to a limited volume of cortex allowed to differentiate true 3-D nodes (54.5%) from the superimposition of vessels lying on different planes. The network model with elongated meshes preferentially oriented along the longitudinal axis of the diaphysis in his static configuration is not very different from the vascular anatomy depicted in the 2-D traditional models; however, the semi-quantitative morphometric analysis applied to the former supported the notion of a multidirectional microvascular network allowing change of flow according to the functional requirements. Other peculiar aspects not previously reported were cutting cone loops, blind-end and short-radius-bent vessels, and button-holes figures. The network design and node distribution were consistent with the straight trajectory of the secondary remodeling, with the proximal-to-distal and distal-to-proximal advancement directions of the cutting cones and with two main modes of node formation, namely bifurcation of the cutting cone and interception with pre-existing canals. The general organization of the network and its uninterrupted transformation during bone modeling and remodeling suggested a substantial plasticity of the intracortical vascular system capable to adapt itself to the changeable haemodynamic conditions

Treatment of esophageal achalasia in children: Today and tomorrow

Esophageal achalasia (EA) is a rare esophageal motility disorder in children. Laparoscopic Heller myotomy (LHM) represents the treatment of choice in young patients. Peroral endoscopic myotomy (POEM) is becoming an alternative to LHM. The aim of this study is to evaluate the effectiveness, safety, and outcomes of POEM vs LHM in treatment of children with EA. Data of pediatric patients with EA, who underwent LHM and POEM from February 2009 to December 2013 in two centers, were collected. Eighteen patients (9 male, mean age: 11.6 years; range: 2-17 years) were included. Nine patients (6 male, mean age: 10.7 years; range: 2-16 years) underwent LHM, and the other 9 (3 males, mean age: 12.2 years; range: 6-17 years) underwent POEM procedure. Mean operation time was shorter in POEM group compared with LHM group (62/149 minutes). Myotomy was longer in POEM group than in LHM group (11/7 cm). One major complication occurred after LHM (esophageal perforation). No clinical and manometric differences were observed between LHM and POEM in follow-up. The incidence of iatrogenic gastroesophageal reflux disease was low (1 patient in both groups). Results of a midterm follow-up show that LHM and POEM are safe and effective treatments also in children. Besides, POEM is a mini-invasive technique with an inferior execution timing compared to LHM. A skilled endoscopic team is mandatory to perform this procedur

In situ alloying of a modified inconel 625 via laser powder bed fusion: Microstructure and mechanical properties

This study investigates the in situ alloying of a Ni-based superalloy processed by means of laser powder bed fusion (LPBF). For this purpose, Inconel 625 powder is mixed with 1 wt.% of Ti6Al4V powder. The modified alloy is characterized by densification levels similar to the base alloy, with relative density superior to 99.8%. The material exhibits Ti-rich segregations along the melt pool contours. Moreover, Ti tends to be entrapped in the interdendritic areas during solidification in the as-built state. After heat treatments, the modified Inconel 625 version presents greater hardness and tensile strengths than the base alloy in the same heat-treated conditions. For the solution annealed state, this is mainly attributed to the elimination of the segregations into the interdendritic structures, thus triggering solute strengthening. Finally, for the aged state, the further increment of mechanical properties can be attributed to a more intense formation of phases than the base alloy, due to elevated precipitation strengthening ability under heat treatments. It is interesting to note how slight chemical composition modification can directly develop new alloys by the LPBF process

Microstructure and Residual Stress Evolution of Laser Powder Bed Fused Inconel 718 under Heat Treatments

The current work aimed to study the influence of various heat treatments on the microstructure, hardness, and residual stresses of Inconel 718 processed by laser powder bed fusion process. The reduction in residual stresses is crucial to avoid the deformation of the component during its removal from the building platform. Among the different heat treatments, 800 °C kept almost unaltered the original microstructure, reducing the residual stresses. Heat treatments at 900, 980, and 1065 °C gradually triggered the melt pool and dendritic structures dissolution, drastically reducing the residual stresses. Heat treatments at 900 and 980 °C involved the formation of δ phases, whereas 1065 °C generated carbides. These heat treatments were also performed on components with narrow internal channels revealing that heat treatments up to 900 °C did not trigger sintering mechanisms allowing to remove the powder from the inner channels