Proceedings of the Workshop on Adaptation of Plants to Soil Stresses

Sustainable production of food and forage with a focus on plant adaptation to stress environments will be a continued priority for developing countries in the future. Since many areas of the world which support substantial human populations are drought prone, such as the subsaharan African zone and others, the primary focus has been on drought. However, one of the greatest restraints to sustainability of agriculture worldwide is the lack of sufficient soil nutrients for crop growth, or other soil constraints such as acidity or salinity which hinder crop production substantially. Optimizing soil fertility or amending acid and saline soils to achieve high production is difficult in areas of low economic stability since inputs are costly or quite often technically not feasible. The other obvious alternative to increase stability in stress areas is by genetic improvement of crops. Dr. Donald L. Plucknett, in a recent lecture on science and agricultural transformations, stated that while not all yield gains in the Green Revolutions can be attributed to plant breeding, it is doubtful such gains would have taken place without the new varieties or hybrids . Development and release of new and improved germplasm is probably the most economic method of technology transfer currently available. According to Dr. Plucknett, most studies indicate about half of yield gains can be attributed to genetic improvements. This statistic is undoubtedly argued in many circles, but regardless of the final figure, gains from genetic improvement are substantial

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Proceedings of the Workshop on Adaptation of Plants to Soil Stresses

Sustainable production of food and forage with a focus on plant adaptation to stress environments will be a continued priority for developing countries in the future. Since many areas of the world which support substantial human populations are drought prone, such as the subsaharan African zone and others, the primary focus has been on drought. However, one of the greatest restraints to sustainability of agriculture worldwide is the lack of sufficient soil nutrients for crop growth, or other soil constraints such as acidity or salinity which hinder crop production substantially. Optimizing soil fertility or amending acid and saline soils to achieve high production is difficult in areas of low economic stability since inputs are costly or quite often technically not feasible. The other obvious alternative to increase stability in stress areas is by genetic improvement of crops. Dr. Donald L. Plucknett, in a recent lecture on science and agricultural transformations, stated that while not all yield gains in the Green Revolutions can be attributed to plant breeding, it is doubtful such gains would have taken place without the new varieties or hybrids . Development and release of new and improved germplasm is probably the most economic method of technology transfer currently available. According to Dr. Plucknett, most studies indicate about half of yield gains can be attributed to genetic improvements. This statistic is undoubtedly argued in many circles, but regardless of the final figure, gains from genetic improvement are substantial