Continuous Integration of Risk Management in a Business Process Reengineering: Towards Optimization through Machine Learning

To improve their market position and competitiveness, organizations aim to shorten production times, cut costs, and boost the quality and variety of their products. While Business Process Reengineering (BPR) is a good method to achieve these goals, implementing it can be risky: any change to a task in the initial process directly affects the final process's performance in terms of time, cost, and quality. This article, drawing on design science, a literature review, and a field study with responses from executives and managers of two companies in the aerospace and automotive sectors in Morocco to measure their satisfaction and identify their risk management needs, provides an overview of the BPR method, its implementation frameworks and methodologies, and explains the importance of risk management in such projects. It suggests an improved continuous risk management process for BPR projects that enhances the gathering and use of risk management data through machine learning. Doi: 10.28991/ESJ-2024-08-03-019 Full Text: PD

Comparative Study of Robust RSC Control of Doubly Fed Induction Generator Based Wind Turbine under Grid Frequency and Voltage Variations

The configuration of a grid-connected doubly fed induction generator (DFIG) for wind energy generation systems consists of direct coupling of the generator stator windings with the grid and partial coupling of the rotor through power converters. This structure makes the system sensitive to the fault grid. Thus, robust control techniques are required to deal with the undesirable transient sequences in the network. In this paper, two robust controllers have integrated to regulate the stator active and reactive power of DFIG based wind turbine. Then, they have been tested and compared to verify their performances when abnormal grid networks have occurred. Firstly, we used high order sliding mode (HOSM) based Super Twisting, which keeps the same conventional sliding mode performances, such as fast dynamic response and redundancy to the extern disturbances, with a simple design and chattering reduction. Secondly, we implement the backstepping control approach which is known for its robustness in transient sequences. A number of simulations have carried out to evaluate the ride-through performance of both control strategies in case of low grid voltage dips and grid frequency variations

TACTICAL SKILLS AND THEIR RELATIONSHIP WITH THE LEVEL OF TACTICAL THINKING AMONG FOOTBALL PLAYERS - A FIELD STUDY CONDUCTED ON CLUBS FROM BOUIRA PROVINCE, ALGERIA

This study aimed to identify the relationship between the tactical skills level of tactical thinking among football players. To achieve this, the researchers used the analytical descriptive approach to preserve the suitability nature of the study on a sample of 75 players from 3 clubs of football at the level of clubs Bouira province, randomly chosen. By testing their standard tactical skills and tactical thinking, it has been found the following results: there is a strong positive relationship between the level of tactical skill and tactical thinking. In the light of the outcome, the researchers recommended as follows: (1) focus on footwork drills competent skills game handlers collective or tactical skills and connect it with the tactical thinking and (2) the need to identify the causes of ambitious player’s sports teams

Feedback Gain Design Method for the Full-Order Flux Observer in Sensorless Control of Induction Motor

This paper deals with a feedback gain design method for the full-order flux observer with adaptive speed loop, which enables the minimizing the unstable operation region of this observer to a line in the torque-speed plane. The stability in regenerating mode is studied using necessary condition of stability based on determinant of matrix and a linearized model. Simulations results where the proposed observer is compared with an exiting solution (where the unstable region is not totally removed) are presented to validate the proposed observer design

Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents

Corrigiola telephiifolia Pourr. (Caryophyllaceae) is a Moroccan medicinal plant. Despite its popular usage, no study has been published concerning its toxicological profile. The acute toxicity of C. telephiifolia root extract was evaluated by giving it orally to mice at single doses of 5000, 10000, and 14000 mg/kg bodyweight. The extract was also administered at doses of 5, 70, and 2000 mg/kg bodyweight per day to rats for a forty-day toxicity study. No mortality or signs of toxicity were observed in the acute study. In the forty-day study in rats, the extract at 5 mg/kg/day showed no toxicological effects in either sex. At 70 mg/kg/day, the treated group differed from the control only by a significant decrease in serum concentrations of sodium and chloride ions (P < .05). At the dose of 2000 mg/kg/day, the extract significantly increased the serum concentrations of creatinine, alkaline phosphatase, gamma-glutamyltransferase and phosphorus (P < .05) all suggestive of functional nephrotoxicity and hepatotoxicity. The relative bodyweight of both sexes decreased at the dose of 2000 mg/kg/day, with a fast recovery for males. Histological examination did not reveal any treatment-related effects. In conclusion, Corrigiola extract appears safe at the doses used ethno-medicinally. Much higher doses pose toxicological risks

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis

BACKGROUND & AIMS: Steatohepatitis (SH) is associated with mitochondrial dysfunction and excessive production of superoxide, which can then be converted into H(2)O(2) by SOD2. Since mitochondrial GSH (mGSH) plays a critical role in H(2)O(2) reduction, we explored the interplay between superoxide, H(2)O(2), and mGSH in nutritional and genetic models of SH, which exhibit mGSH depletion. METHODS: We used isolated mitochondria and primary hepatocytes, as well as in vivo SH models showing mGSH depletion to test the consequences of superoxide scavenging. RESULTS: In isolated mitochondria and primary hepatocytes, superoxide scavenging by SOD mimetics or purified SOD decreased superoxide and peroxynitrite generation but increased H(2)O(2) following mGSH depletion, despite mitochondrial peroxiredoxin/thioredoxin defense. Selective mGSH depletion sensitized hepatocytes to cell death induced by SOD mimetics, and this was prevented by RIP1 kinase inhibition with necrostatin-1 or GSH repletion with GSH ethyl ester (GSHee). Mice fed the methionine-choline deficient (MCD) diet or MAT1A(-/-) mice exhibited reduced SOD2 activity; in vivo treatment with SOD mimetics increased liver damage, inflammation, and fibrosis, despite a decreased superoxide and 3-nitrotyrosine immunoreactivity, effects that were ameliorated by mGSH replenishment with GSHee, but not NAC. As a proof-of-principle of the detrimental role of superoxide scavenging when mGSH was depleted transgenic mice overexpressing SOD2 exhibited enhanced susceptibility to MCD-mediated SH. CONCLUSIONS: These findings underscore a critical role for mGSH in the therapeutic potential of superoxide scavenging in SH, and suggest that the combined approach of superoxide scavenging with mGSH replenishment may be important in SH

Rôle des mitochondries dans l'hépatotoxicité induite par le tamoxifène

PARIS-BIUP (751062107) / SudocSudocFranceF

Influence des polymorphismes génétiques du TNFa et de l IL1b sur le développement du carcinome hépatocellulaire et le décès chez des patients atteints d une cirrhose alcoolique ou liée au virus de l hépatite C

Certains polymorphismes génétiques de cytokines pro-inflammatoires augmentant l expression des gènes ont été décrits dans les promoteurs de TNFa (Tumor Necrosis Factor a) et l IL1b (Interleukine 1b). Le but de ce travail a été d étudier le rôle des polymorphismes G-238A, G-308A et C-863A dans le promoteur du gène de TNFa et les polymorphismes T-31C et C-511T du gène de l IL1b dans la survenue du CHC (carcinome hépatocellulaire) chez 230 patients atteints d une cirrhose alcoolique et chez 253 patients atteints d une cirrhose virale C. Les résultats obtenus chez les patients alcooliques montraient une survenue précoce du CHC ainsi que de la mort chez les individus portant l allèle TNF-238A et l allèle IL1-511C, respectivement. De même, nous avons montré qu il existait un risque accru de décès chez les patients avec cirrhose virale C et porteurs d au moins un allèle TNF-308A. En conclusion, les polymorphismes génétiques augmentant l expression de TNFa et de l IL1b sembleraient favoriser l évolution de la cirrhose alcoolique ou liée au virus de l hépatite C vers le CHC.DIJON-BU Médecine Pharmacie (212312103) / SudocSudocFranceF