8 research outputs found
SEPARATION OF TWO CONJUGATES OF CLOFJBRIC ACID (CPIB) FOUND IN THE URINE OF SUBJECTS TAKING CLOFIBRATE
Different renal effects of two inhibitors of catechol‐O‐methylation in the rat: Entacapone and CGP 28014
A mouse peritonitis model for the study of glycopeptide efficacy in GISA infections
In recent years, the emergence of Staphylococcus aureus strains with reduced susceptibility to glycopeptides has raised considerable concern. We studied the efficacy of vancomycin and teicoplanin, as well as cloxacillin and cefotaxime, against the infection caused by four S. aureus strains with different glycopeptide and β-lactam susceptibilities (strains A, B, C, and D; MICs for vancomycin of 1, 2, 4, and 8 µg/ml respectively), using a modified model of mouse peritonitis. This optimized model appeared to be straightforward and reproducible, and was able to detect low differences in bacterial killing between antibiotics and also between different S. aureus strains. Bactericidal activities in peritoneal fluid for vancomycin, teicoplanin, cloxacillin, and cefotaxime decreased from -2.98, -2.36, -3.22, and -3.57 log10 cfu/ml, respectively, in infection by strain A (MICs for vancomycin and cloxacillin of 1 and 0.38 µg/ml, respectively) to -1.22, -0.65, -1.04, and +0.24 in peritonitis due to strain D (MICs for vancomycin and cloxacillin of 8 and 1,024 µg/ml). Our data confirm the superiority of β-lactams against methicillin-susceptible S. aureus and show that bactericidal activity of glycopeptides decreases significantly with slight increases in MICs; this finding suggests a reduced efficacy of glycopeptides in the treatment of serious glycopeptide-intermediate S. aureus infection
Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease.
Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations.
CIRCULATING CATECHOLAMINE, THYROTROPHIN, THYROID HORMONE AND PROLACTIN RESPONSES OF NORMAL SUBJECTS TO ACUTE COLD EXPOSURE
Rare and low-frequency coding variants alter human adult height
Pathophysiology, epidemiology and therapy of agein