Pairwise fuzzy irresolute mappings

summary:In this paper the concepts of fuzzy irresolute and fuzzy presemiopen mappings due to Yalvac [12] are generalized to fuzzy bitopological spaces and their basic properties and characterizations are studied

Reproducibilty of partial weight bearing

Objectives: To find out whether partial weight bearing can be reproduced and retained. Design: In vivo experiment in normal subjects. Intervention: Training for partial weight bearing (25% of body weight) using bathroom scales. Main outcome measurement: Reproducibility on force platform immediately after training and after 60 min. Results: Twelve subjects were asked to reproduce 25% of their body weight through either the dominant or non-dominant limb on force platform after three practice attempts on bathroom scales with concurrent visual feedback. No feedback was provided after the measurements on force plate. The process was repeated after 1 h without any practice sessions in the interim period to find out if the weight practised could be retained. The mean 0-min reading was found to be 25.9% of body weight while the mean 60-min reading was found to be 24.4%. The p-value for the difference between the two means was found to be 0.3841. Conclusions: This study indicates that partial weight bearing instructions can be quantified and graded. Simple bathroom scales are sufficient to educate the patients and this can be practised at home after an initial period of supervision

Sedation failures in children undergoing MRI and CT: is temperament a factor?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73396/1/j.1460-9592.2000.00510.x.pd

Priorities for disclosure of the elements of informed consent for research: a comparison between parents and investigators

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73134/1/j.1460-9592.2002.00851.x.pd

Genetic Relationship between the Muscids Using RAPD-PCR as marker

Abstract Random Amplified Polymorphic DNA-Polymerase Chain Reaction (RAPD-PCR

Radiolabeled humanized anti-CD3 monoclonal antibody visilizumab for imaging human T-lymphocytes

Visilizumab is an IgG2 humanized monoclonal antibody (mAb) characterized by non-FcγR binding and specific to the CD3 antigen, expressed on more than 95% of circulating resting T-lymphocytes and on activated T-lymphocytes homing in inflamed tissues. We hypothesized that the use of a radiolabeled anti-CD3 antibody might serve as a diagnostic tool for imaging T-cell traffic and lymphocytic infiltration of tissues and organs affected by autoimmune diseases. Here we describe the results of in vitro and animal experiments with 99mTc-succinimidyl-6-hydrazinonicotinate hydrochloride (SHNH)-visilizumab. Methods: For mAb labeling, we used a 2-step method with a heterobifunctional linker SHNH. Several titrations were performed to obtain the best labeling efficiency. In vitro quality controls included stability assay, cysteine challenge, sodium dodecyl sulfate polyacrylamide gel electrophoresis, binding assay, and immunoreactivity assay. In vivo studies by high-resolution images were performed at 6 and 24 h after the injection of 99mTc-SHNH-visilizumab. These included cell-targeting experiments in BALB/c mice xenografted subcutaneously with an increasing number of HuT78 cells in the leg and displaced with an excess of cold antibody. We also studied irradiated severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood mononuclear cells (hPBMCs) and injected with 99mTclabeled visilizumab or control mAb. After dynamic imaging for 3 h, major organs were removed, counted, and processed for immunohistologic examination. Results: Visilizumab was labeled with HYNIC with high labeling efficiency (>90%) and high specific activity (SA; 10,360-11,100 MBq/mg), with retained biochemical integrity and in vitro binding activity to CD3-positive cells. The in vivo targeting experiment showed a proportional increase of specific uptake with the number of injected cells, both at 6 and at 24 h, and the in vivo competition study demonstrated more than 60% decreased uptake after an excess of unlabeled antibody. In SCID mice, hPBMCs in different tissues were detected by 99mTc-labeled visilizumab and confirmed by histology. Conclusion: Visilizumab can be efficiently labeled with 99mTc with high efficiency and SA and could be a valuable tool for the study of human T-lymphocyte trafficking and lymphocytic infiltration of tissues and organs. Copyright © 2009 by the Society of Nuclear Medicine, Inc

Respiratory Effects of Amifostine and DRDE-07: Probable Prophylactic Agents of Sulphur Mustard in Rats

Amifostine (S-2[3-aminopropylamino]ethyl phosphorothioate) and one of its analogues,DRDE-07 (S-2[2-aminoethylamino]ethyl phenyl sulphide) are promising prophylactic agents forsulphur mustard (SM; a blistering agent) toxicity. When given orally, DRDE-07 was more effectivethan amifostine as a prophylactic agent against SM administered percutaneously. Variouspharmacological and toxicological studies are required before the introduction of a chemical asa drug. The respiratory effects of amifostine and DRDE-07 were carried out in rats using a bodyplethysmograph fitted with a volumetric pressure transducer for sensing the respiratory flowsignals. The signals were amplified, digitised, and stored on a personal computer for furtheranalysis. After taking control recordings of respiratory signals, different doses (0.5 LD50, 1.0 LD50and 2.0 LD50) of amifostine and DRDE-07 were administered orally (LD50 amifostine = 2262 mg/kg; DRDE-07 = 1599 mg/kg), and the respiratory changes were monitored for 4 h. Amifostine andDRDE-07 showed a uniform breathing pattern even in 2.0 LD50 dose. However, a significant dosedependentdecrease in respiratory frequency was observed following amifostine administration.DRDE-07 did not show any significant change. The tidal volume was not altered significantlyboth in amifostine and DRDE-07 administered animals. The study shows that DRDE-07, even inlethal doses, may not affect the respiration immediately, whereas, amifostine may decrease therespiratory frequency

Residual effect of nitrogen levels and weed control methods on growth, yield and economics of wheat grown after rice

A field experiment was laid out in split plot design on residual effect of treatments comprising three nitrogen levels viz. N75 (N1), N100 (N2) and N125 (N3) in main-plot treatments and seven weed control treatments viz. (W1-butachlor + 1 Hand Weeding, W2-butachlor + 2 Mechanical Weeding, W3-butachlor + 2,4-D, W4-bispyribac sodium, W5-butachlor + bispyribac sodium, W6-HW-2, W7- control) as sub-plot treatments conducted during 2015-16 and 2016-17 at the Rajaula Agriculture Farm, MGCGVV, Satna (M.P.) to study the residual effect of N-levels and weed control methods on growth, yield and economics of wheat grown after rice. In case of succeeding wheat, the residual 125 kg N/ha performed the best with respect to growth, yield-attributes with the result 31.11 q/ha grain yield and Rs.33509/ha income. While, under sub plot treatments, Hand weedings two times were recorded significant grain yield (28.66 q/ha) and straw yield (38.17 q/ha) at (P <0.05) over control. However it was found non-significant different and also noticed higher over rest treatments. In this succession, Butachlor + 2, 4-D (0.80 kg/ha) was higher but in second position and similar trend was observed in successive way with rest of treatments

Factors associated with acute kidney injury or failure in children undergoing cardiopulmonary bypass: a case‐controlled study

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87176/1/j.1460-9592.2011.03532.x.pd