32 research outputs found
Π‘Π²Π΅ΡΡ Π²ΡΡΠΎΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΉ ΠΏΠΎΠ»ΠΈΡΡΠΈΠ»Π΅Π½ (Π‘ΠΠΠΠ) ΠΊΠ°ΠΊ ΠΎΡΠ½ΠΎΠ²Π° ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ° Π΄Π»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ 3D ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ
The study is devoted to the development of an artificial material based on the ultrahigh-molecular weight polyethylene (UHMWPE) with a porous or cellular 3D structure as a cellular matrix β a framework for growing cell cultures. The development of such matrix provides support for neuronal cell culture under conditions that mimick those that exist in the living body. Typically, in vitro cellular studies are conducted in a 2D format, which limits intercellular interactions, morphology, differentiation, survival, signaling responses, gene expression and proliferation that are found in vivo. Here, we propose to use UHMWPE as a material of the cellular matrix, the ultra-high molecular weight polyethylene. UHMWP is a bioinert substance, wich allows forming a system of open connected pores needed to provide cellular life conditions with supply of nutrients and oxygen as well as the removal of waste products, the possibility of intercellular communication, etc. As a result, the use of UHMWPE as a cellular matrix will allow to study the processes occurring in cells in the 3D environment.Π Π°Π±ΠΎΡΠ° ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° Π°Π½Π°Π»ΠΈΠ·Ρ ΡΠ²ΠΎΠΉΡΡΠ² ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ²Π΅ΡΡ
Π²ΡΡΠΎΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΡΡΠΈΠ»Π΅Π½Π° (Π‘ΠΠΠΠ) Ρ ΠΏΠΎΡΠΈΡΡΠΎΠΉ ΠΈΠ»ΠΈ ΡΡΠ΅ΠΈΡΡΠΎΠΉ 3D-ΡΡΡΡΠΊΡΡΡΠΎΠΉ, ΠΊΠΎΡΠΎΡΡΠΉ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ° β ΠΊΠ°ΡΠΊΠ°ΡΠ° Π΄Π»Ρ Π²ΡΡΠ°ΡΠΈΠ²Π°Π½ΠΈΡ ΠΊΡΠ»ΡΡΡΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ. Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ°ΠΊΠΎΠ³ΠΎ ΠΊΠ°ΡΠΊΠ°ΡΠ° ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅Ρ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
, ΠΏΡΠΈΠ±Π»ΠΈΠΆΠ΅Π½Π½ΡΡ
ΠΊ ΡΠ΅ΠΌ, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΡΡΠ΅ΡΡΠ²ΡΡΡ Π² ΠΆΠΈΠ²ΠΎΠΌ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅. ΠΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ in vitro ΠΏΡΠΎΠ²ΠΎΠ΄ΡΡ Π² 2D-ΡΠΎΡΠΌΠ°ΡΠ΅, ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΠΎ ΡΠ²ΠΎΠ΅ΠΉ ΠΏΡΠΈΡΠΎΠ΄Π΅ ΠΎΠ³ΡΠ°Π½ΠΈΡΠΈΠ²Π°Π΅Ρ ΠΌΠ΅ΠΆΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ, ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡ, Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΡ, Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ, ΡΠΈΠ³Π½Π°Π»ΡΠ½ΡΠ΅ ΠΎΡΠ²Π΅ΡΡ, ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π³Π΅Π½ΠΎΠ² ΠΈ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΡ, Π½Π°Π±Π»ΡΠ΄Π°Π΅ΠΌΡΠ΅ in vivo. Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ° ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ Π±ΠΈΠΎΠΈΠ½Π΅ΡΡΠ½ΡΠΉ ΡΠ²Π΅ΡΡ
Π²ΡΡΠΎΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΉ ΠΏΠΎΠ»ΠΈΡΡΠΈΠ»Π΅Π½ (Π‘ΠΠΠΠ), ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°ΡΡ ΡΠΈΡΡΠ΅ΠΌΡ ΠΎΡΠΊΡΡΡΡΡ
ΡΠ²ΡΠ·Π°Π½Π½ΡΡ
ΠΏΠΎΡ Ρ ΡΠ΅Π»ΡΡ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΆΠΈΠ·Π½Π΅Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ β βΠΏΠΎΠ΄Π²ΠΎΠ΄β ΠΏΠΈΡΠ°Π½ΠΈΡ ΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°, ΡΠ΄Π°Π»Π΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΠΆΠΈΠ·Π½Π΅Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΌΠ΅ΠΆΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΡΠ²ΡΠ·Π΅ΠΉ ΠΈ Ρ.Π΄. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π‘ΠΠΠΠ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ° ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ ΠΈΠ·ΡΡΠΈΡΡ ΠΏΡΠΎΡΠ΅ΡΡΡ, ΠΏΡΠΎΡΠ΅ΠΊΠ°ΡΡΠΈΠ΅ Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ
Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
3D-ΡΡΠ΅Π΄Ρ
Follow-up study of the patients operated for traumatic subdural hematomas
In 56 patients operated for traumatic subdural hematomas clinical manifestations were analysed (8 main syndromes of the remote period) as well as the degree of neurologic rehabilitation and the level of social-occupational adaptation. Such adaptation appeared to be rather high: 66,1% of the patients were able to resume work. The highest lethality was in the acute period; the worst rehabilitation and follow-up adaptation were observed in elderly and old patients who were in comatose state before the operation and had severe accompanying contusion of the brain. Policy of drug treatment was determined in patients with traumatic subdural hematomas regarding peculiarities and manifestations of the syndromes (urgent operation, if necessary - cranioplasty, psychologic support in the remote period, resorption therapy and symptomatic drugs)
Follow-up study of the patients operated for traumatic subdural hematomas
In 56 patients operated for traumatic subdural hematomas clinical manifestations were analysed (8 main syndromes of the remote period) as well as the degree of neurologic rehabilitation and the level of social-occupational adaptation. Such adaptation appeared to be rather high: 66,1% of the patients were able to resume work. The highest lethality was in the acute period; the worst rehabilitation and follow-up adaptation were observed in elderly and old patients who were in comatose state before the operation and had severe accompanying contusion of the brain. Policy of drug treatment was determined in patients with traumatic subdural hematomas regarding peculiarities and manifestations of the syndromes (urgent operation, if necessary - cranioplasty, psychologic support in the remote period, resorption therapy and symptomatic drugs)