THE SEARCH FOR A "NEW" RHETORIC OF THE LEFT: A LOOK AT STRATEGIES OF THE DEMOCRATS AND LABOUR

This chapter studies the two major left-of-centre parties in the US and the UK. Both found themselves losing elections in the 1980s and their leaders came to the same conclusion: that the voters perceived the parties as having shifted too far to the left and so, if they wanted to win, they would have to move toward the centre. In America, Bill Clinton succeeded in winning the presidency in 1992 but after a series of policy disasters, the Democrats then lost Congress two years later. Labour followed a similar strategy with less success at first-unexpectedly losing the 1992 election-but then began a long run of government from 1997 to 2010. The article not only examines their strategies and the rhetoric that reflected them, making a close comparison between the two countries, but also compares and contrasts it to actual policy decisions

The Grizzly, April 7, 1989

History in Making: Middle States Arrive Sunday • APO Holds Local Fraternity Chapter Conference • Letters: Normal Pledging O.K.; Booby not Prize • DeLeon Woos Wismer • Hundreds to Storm Campus • Friday\u27s Fun, But Not Food Fantasy • Men\u27s Lacrosse Begins with a Bang! • Bowers Leads U.C. to Win • Driscoll, Ursinus Set High Goals • Tough Schedule to Benefit U.C. Lax • Two Week Pledging Proposed by Subcommittee on Greeks • Boston: Seats Going Fast • It\u27s Tenure Time Once Again! • U.S.G.A Update • Cinders to Rock U.C. • U.S.G.A. Needs You! • Rumors a Real Bomb • Take a Bite! • College Displays Crime Statshttps://digitalcommons.ursinus.edu/grizzlynews/1234/thumbnail.jp

BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles

Development of biofluid-based molecular diagnostic tests for cancer is an important step towards tumor characterization and real-time monitoring in a minimally invasive fashion. Extracellular vesicles (EVs) are released from tumor cells into body fluids and can provide a powerful platform for tumor biomarkers because they carry tumor proteins and nucleic acids. Detecting rare point mutations in the background of wild-type sequences in biofluids such as blood and cerebrospinal fluid (CSF) remains a major challenge. Techniques such as BEAMing (beads, emulsion, amplification, magnetics) PCR and droplet digital PCR (ddPCR) are substantially more sensitive than many other assays for mutant sequence detection. Here, we describe a novel approach that combines biofluid EV RNA and BEAMing RT-PCR (EV-BEAMing), as well droplet digital PCR to interrogate mutations from glioma tumors. EVs from CSF of patients with glioma were shown to contain mutant IDH1 transcripts, and we were able to reliably detect and quantify mutant and wild-type IDH1 RNA transcripts in CSF of patients with gliomas. EV-BEAMing and EV-ddPCR represent a valuable new strategy for cancer diagnostics, which can be applied to a variety of biofluids and neoplasms

The genetic architecture of type 2 diabetes

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support a major role for lower-frequency variants in predisposition to type 2 diabetes

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

“‘The Avengers Always Stand Ready to Do Their Part’: The Avengers and the Vietnam War

International audienceThis chapter explores ways in which The Avengers comic books reflected anxieties and debates linked to the Vietnam Wa

"Fear Is the Path to the Dark Side": Nuclear Weapons and the Death Star

International audienceThis chapter examines the relationship between real-life nuclear weapons and the imaginary Death Star in the work of George Luca

Cinéma et Guerre froide: L’Imaginaire au pouvoir

International audienc

The Cold War and Entertainment Television

International audienceAn essential dimension of the Cold War took place in the realm of ideas and culture. While much work exists on cinema, relatively little research has been conducted on this subject in relation to television, despite the latter being a technology and popular cultural form that emerged during this period. This book rectifies that absence by examining the impact of the Cold War on entertainment television, and underlines the comparative aspect by studying programs from both blocs—without forgetting, of course, the outsize impact of American television. Although most of the focus is on the two main protagonists, the US and the USSR, chapters also consider programming from the UK, Czechoslovakia, Romania, and both East and West Germany.This book represents a contribution to the debate about the cultural Cold War through a rigorously comparative analysis of the two blocs. For this reason, the approach used is thematic. The study begins by considering the subject of censorship, and then goes on to look at the very particular case of the two Germanys. A series of comparative genre studies follow, including police and war, variety shows, and documentaries and docudramas. Perhaps surprisingly, the similarities are often greater than the differences between television in the two blocs